Gene/Proteome Database (LMPD)

LMPD ID
LMP000646
Gene ID
14538
Species
Mus musculus (Mouse)
Gene Name
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
Gene Symbol
Gcnt2
Synonyms
5330430K10Rik; IGnT; IGnTA; IGnTB; IGnTC
Alternate Names
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase; I-branching enzyme; N-acetylglucosaminyltransferase; beta-1,6-N-acetylglucosaminyltransferase; glucosaminyltransferase, I-branching enzyme; large I antigen-forming beta-1,6-N-acetylglucosaminyltransferase
Chromosome
13
Map Location
13 A5|13 20.12 cM
EC Number
2.4.1.150

Proteins

N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform A
Refseq ID NP_032131
Protein GI 39995100
UniProt ID P97402
mRNA ID NM_008105
Length 401
RefSeq Status VALIDATED
MPPSVRYFFIVSVTTVIVFIVLYVLSFGGDQSYQKLNISDSVMLAQVCSSFIDGKSRFLWRNKLMIHEKPSCTEYVTQSHYITAPLSQEEVDFPLAYVMVIHHNFDTFARLFRAIFMPQNIYCVHVDEKATAEFKGAVEQLVSCFPNAFLASKMEPVVYGGISRLQADLNCIKDLSTSEVPWKYAINTCGQDFPLKTNKEIVQYLKGLKGKNLTPGVLPPAHAIGRTRYVHREHLSKELSYVIRTTALKPPPPHNLTIYFGSAYVALSREFANFVLRDPRAVDLLHWSKDTFSPDEHFWVTLNRIPGVPGSMPPNASWTGNLRAVKWMDMEAKHGGCHGHYVHGICIYGNGDLQWLINSQSLFANKFELNTYPLTVECLELRLRERTLNQSEIAIQPSWYF
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform B
Refseq ID NP_076376
Protein GI 39995102
UniProt ID Q6T5E4
mRNA ID NM_023887
Length 401
RefSeq Status VALIDATED
MGSWKYSLFSLSLIAALMLMFMYDRKLWKNYHFPRAVSNISVLAEVCLQMFSGESFYTADSARKTTLENFTCPEYKIQNHYITETLSEEEARFPLAFTLTIHKDYDTFERLFRAIYMPQNVYCVHVDSKATDTFKEEVRQLLSCFPNAFLASRMEPVVYGGFSRLQADLNCMKDLVASKIPWKYVLNTCGQDFPLKTNKEIVQYLKRFIGKNLTPGVLPPAHAVGRTKYVHQELLDHKNPYVHNTARLKAPPPHNLTIYFGTAYVALTREFANFVLKDQRSVDLISWSKDTYSPDEHFWVTLNRIPGVPGSMPPNASWTGNLRAVKWMDMEAKHGGCHGHYVHGICIYGNGDLQWLINSQSLFANKFELNTYPLTVECLELRLRERTLNQSEIAIQPSWYF
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform C
Refseq ID NP_573482
Protein GI 39995104
UniProt ID Q7TPQ8
mRNA ID NM_133219
Length 401
RefSeq Status VALIDATED
MSLRGKVFAVSALSVVIFVVFYHSQLSLPNLYQQLNSSSERTSVTICDYGLQNHTFFTTGDTSPHPLERLSCPQYRIQSHYITSPLSEEEAAFPLAYIMVIHKDFDTFERLFRAIYMPQNVYCVHVDSKATDTFKEAVRQLLSCFPNAFLASKVEQVVYGGFSRLQADLNCMKDLVASKVPWKYVLNTCGQDFPLKTNKEIINHLKRFKGKNITPGVLPPAYIVVRTKYVHQERKGKDGYFMHKTNILKTPPPHQLIIYFGTAYVALTRDFVNFILNDERAIALLEWSKDTYSPDEHFWVTLNRIPGVPGSMPPNASWTGNLRAVKWMDMEAKHGGCHGHYVHGICIYGNGDLQWLINSQSLFANKFELNTYPLTVECLELRLRERTLNQSEIAIQPSWYF

Gene Information

Entrez Gene ID
14538
Gene Name
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
Gene Symbol
Gcnt2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0008109 IEA:UniProtKB-EC F N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity
GO:0008375 IDA:MGI F acetylglucosaminyltransferase activity
GO:0036438 IEA:Ensembl P maintenance of lens transparency
GO:0010812 IEA:Ensembl P negative regulation of cell-substrate adhesion
GO:0070374 IMP:UniProt P positive regulation of ERK1 and ERK2 cascade
GO:0030335 IEA:Ensembl P positive regulation of cell migration
GO:0008284 IMP:UniProt P positive regulation of cell proliferation
GO:0010718 IMP:UniProt P positive regulation of epithelial to mesenchymal transition
GO:0034116 IEA:Ensembl P positive regulation of heterotypic cell-cell adhesion
GO:0051897 IMP:UniProt P positive regulation of protein kinase B signaling
GO:0010608 IMP:UniProt P posttranscriptional regulation of gene expression
GO:0006486 IEA:UniProtKB-UniPathway P protein glycosylation
GO:0007179 IMP:UniProt P transforming growth factor beta receptor signaling pathway

KEGG Pathway Links

KEGG Pathway ID Description
mmu00601 Glycosphingolipid biosynthesis - lacto and neolacto series
mmu01100 Metabolic pathways

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6564 heparan sulfate biosynthesis
PWY-6558 heparan sulfate biosynthesis (late stages)

Domain Information

InterPro Annotations

Accession Description
IPR003406 Glycosyl transferase, family 14

UniProt Annotations

Entry Information

Gene Name
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
Protein Entry
Q7TPQ8_MOUSE
UniProt ID
Q7TPQ8
Species
Mouse

Comments

Comment Type Description
Catalytic Activity UDP-N-acetyl-D-glucosamine + beta-D- galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D- glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R.
Function Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells.
Pathway Protein modification; protein glycosylation.
Similarity Belongs to the glycosyltransferase 14 family. {ECO:0000305}.
Subcellular Location Golgi apparatus membrane; Single-pass type II membrane protein.
Web Resource Name=Functional Glycomics Gateway - GTase; Note=Gcnt2 - I branching beta-6-GlcNAcT2, variant 1 (IGnT); URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_587";
Web Resource Name=Functional Glycomics Gateway - GTase; Note=Gcnt2 - I branching beta-6-GlcNAcT2, variant 3 (IGnT); URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_563";

Identical and Related Proteins

Unique RefSeq proteins for LMP000646 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
39995100 RefSeq NP_032131 401 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform A
39995102 RefSeq NP_076376 401 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform B
39995104 RefSeq NP_573482 401 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform C

Identical Sequences to LMP000646 proteins

Reference Database Accession Length Protein Name
GI:39995102 DBBJ BAE33677.1 401 unnamed protein product [Mus musculus]
GI:39995100 GenBank AAO86063.1 401 beta-1,6-N-acetylglucosaminyltransferase IGnTA [Mus musculus]
GI:39995104 GenBank AAO86065.1 401 beta-1,6-N-acetylglucosaminyltransferase IGnTC [Mus musculus]
GI:39995104 GenBank AAH54845.1 401 Glucosaminyl (N-acetyl) transferase 2, I-branching enzyme [Mus musculus]
GI:39995102 GenBank AAR95649.1 401 I-branching beta-1,6-acetylglucosaminyltransferase family polypeptide 1 [Mus musculus]
GI:39995100 GenBank AAR95650.1 401 I-branching beta-1,6-acetylglucosaminyltransferase family polypeptide 2 [Mus musculus]
GI:39995104 GenBank AAR95651.1 401 I-branching beta-1,6-acetylglucosaminyltransferase family polypeptide 3 [Mus musculus]
GI:39995102 GenBank AAH94572.1 401 Glucosaminyl (N-acetyl) transferase 2, I-branching enzyme [Mus musculus]
GI:39995100 SwissProt P97402.2 401 RecName: Full=N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase; Short=N-acetylglucosaminyltransferase; AltName: Full=I-branching enzyme; AltName: Full=IGNT; AltName: Full=Large I antigen-forming beta-1,6-N-acetylglucosaminyltransferase [Mus musculus]

Related Sequences to LMP000646 proteins

Reference Database Accession Length Protein Name
GI:39995102 DBBJ BAB03495.1 401 beta-1,6-N-acetylglucosaminyltransferase B [Mus musculus]
GI:39995100 DBBJ BAB03496.1 401 beta-1,6-N-acetylglucosaminyltransferase A [Mus musculus]
GI:39995104 DBBJ BAB31918.1 356 unnamed protein product [Mus musculus]
GI:39995100 DBBJ BAC35697.1 401 unnamed protein product [Mus musculus]
GI:39995102 DBBJ BAC36889.1 401 unnamed protein product [Mus musculus]
GI:39995100 GenBank AAB39621.1 400 large I antigen-forming beta-1,6-N-acetylglucosaminyltransferase [Mus musculus]
GI:39995102 GenBank AAO86064.1 401 beta-1,6-N-acetylglucosaminyltransferase IGnTB [Mus musculus]
GI:39995102 GenBank AAR95652.1 400 I-branching beta-1,6-acetylglucosaminyltransferase family polypeptide 1 [Rattus norvegicus]
GI:39995104 GenBank AAR95654.1 400 I-branching beta-1,6-acetylglucosaminyltransferase family polypeptide 3 [Rattus norvegicus]
GI:39995104 GenBank AAH99796.1 400 Glucosaminyl (N-acetyl) transferase 2, I-branching enzyme [Rattus norvegicus]
GI:39995100 GenBank EDL40957.1 402 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme, isoform CRA_a, partial [Mus musculus]
GI:39995100 GenBank EDL98230.1 400 rCG44193, isoform CRA_b [Rattus norvegicus]
GI:39995104 RefSeq NP_001001511.1 400 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase [Rattus norvegicus]
GI:39995100 RefSeq XP_005066422.1 400 PREDICTED: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform C-like isoform X1 [Mesocricetus auratus]
GI:39995104 RefSeq XP_005066423.1 401 PREDICTED: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform C-like isoform X2 [Mesocricetus auratus]
GI:39995104 RefSeq XP_006972853.1 401 PREDICTED: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform C isoform X1 [Peromyscus maniculatus bairdii]
GI:39995102 RefSeq XP_006972854.1 400 PREDICTED: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform C isoform X2 [Peromyscus maniculatus bairdii]
GI:39995102 RefSeq XP_008260597.1 402 PREDICTED: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform X1 [Oryctolagus cuniculus]