Gene/Proteome Database (LMPD)

LMPD ID
LMP000674
Gene ID
7026
Species
Homo sapiens (Human)
Gene Name
nuclear receptor subfamily 2, group F, member 2
Gene Symbol
NR2F2
Synonyms
ARP1; CHTD4; COUPTFB; COUPTFII; NF-E3; NR2F1; SVP40; TFCOUP2
Chromosome
15
Map Location
15q26
Summary
This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Orthologs
View orthologs and multiple alignments for NR2F2

Proteins

COUP transcription factor 2 isoform a
Refseq ID NP_066285
Protein GI 14149746
UniProt ID P24468
mRNA ID NM_021005
Length 414
RefSeq Status REVIEWED
MAMVVSTWRDPQDEVPGSQGSQASQAPPVPGPPPGAPHTPQTPGQGGPASTPAQTAAGGQGGPGGPGSDKQQQQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMAIQ
COUP transcription factor 2 isoform b
Refseq ID NP_001138627
Protein GI 223555949
UniProt ID P24468
mRNA ID NM_001145155
Length 281
RefSeq Status REVIEWED
MQAVWDLEQGKYGFAVQRGRMPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMAIQ
COUP transcription factor 2 isoform c
Refseq ID NP_001138628
Protein GI 223555951
UniProt ID P24468
mRNA ID NM_001145156
Length 261
RefSeq Status REVIEWED
MPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMAIQ
COUP transcription factor 2 isoform c
Refseq ID NP_001138629
Protein GI 223555953
UniProt ID P24468
mRNA ID NM_001145157
Length 261
RefSeq Status REVIEWED
Protein sequence is identical to GI:223555951 (mRNA isoform)

Gene Information

Entrez Gene ID
7026
Gene Name
nuclear receptor subfamily 2, group F, member 2
Gene Symbol
NR2F2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005634 IDA:BHF-UCL C nucleus
GO:0004879 IDA:UniProtKB F ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0042803 IPI:UniProtKB F protein homodimerization activity
GO:0001972 IDA:UniProtKB F retinoic acid binding
GO:0043565 IDA:UniProtKB F sequence-specific DNA binding
GO:0003700 IDA:UniProtKB F sequence-specific DNA binding transcription factor activity
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0003714 TAS:ProtInc F transcription corepressor activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0009952 IEA:Ensembl P anterior/posterior pattern specification
GO:0048514 IEA:Ensembl P blood vessel morphogenesis
GO:0009566 IEA:Ensembl P fertilization
GO:0030900 IEA:Ensembl P forebrain development
GO:0030522 IDA:GOC P intracellular receptor signaling pathway
GO:0060173 IEA:Ensembl P limb development
GO:0006629 TAS:ProtInc P lipid metabolic process
GO:0001893 IEA:Ensembl P maternal placenta development
GO:0045736 IDA:BHF-UCL P negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0010596 IMP:BHF-UCL P negative regulation of endothelial cell migration
GO:0001937 IMP:BHF-UCL P negative regulation of endothelial cell proliferation
GO:0000122 IDA:UniProtKB P negative regulation of transcription from RNA polymerase II promoter
GO:0045892 IDA:BHF-UCL P negative regulation of transcription, DNA-templated
GO:0001764 IEA:Ensembl P neuron migration
GO:0060674 IEA:Ensembl P placenta blood vessel development
GO:0045893 IDA:UniProtKB P positive regulation of transcription, DNA-templated
GO:0009956 IEA:Ensembl P radial pattern formation
GO:0006357 TAS:ProtInc P regulation of transcription from RNA polymerase II promoter
GO:0060849 IMP:BHF-UCL P regulation of transcription involved in lymphatic endothelial cell fate commitment
GO:0032355 IEA:Ensembl P response to estradiol
GO:0007165 TAS:ProtInc P signal transduction
GO:0007519 IEA:Ensembl P skeletal muscle tissue development
GO:0060707 IEA:Ensembl P trophoblast giant cell differentiation

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_27161 Transcriptional regulation of white adipocyte differentiation

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001723 Steroid hormone receptor
IPR003068 Transcription factor COUP
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
nuclear receptor subfamily 2, group F, member 2
Protein Entry
COT2_HUMAN
UniProt ID
P24468
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P24468-1; Sequence=Displayed; Name=2; IsoId=P24468-2; Sequence=VSP_042630; Name=3; IsoId=P24468-3; Sequence=VSP_043897;
Disease Congenital heart defects, multiple types, 4 (CHTD4) [MIM
Function Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. {ECO
Similarity Belongs to the nuclear hormone receptor family. NR2 subfamily.
Similarity Contains 1 nuclear receptor DNA-binding domain.
Subcellular Location Nucleus.
Subunit Interacts with SQSTM1 (By similarity). Binds DNA as a dimer; homodimer or heterodimer with NR2F6. Interacts with NCOA1, NCOA2, NCOA3 and PPARGC1A. Interacts with ZFPM2 (By similarity).
Tissue Specificity Ubiquitous.

Identical and Related Proteins

Unique RefSeq proteins for LMP000674 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
14149746 RefSeq NP_066285 414 COUP transcription factor 2 isoform a
223555949 RefSeq NP_001138627 281 COUP transcription factor 2 isoform b
223555951 RefSeq NP_001138628 261 COUP transcription factor 2 isoform c

Identical Sequences to LMP000674 proteins

Reference Database Accession Length Protein Name
GI:14149746 GenBank JAB22968.1 414 COUP transcription factor 2 isoform a [Callithrix jacchus]
GI:14149746 GenBank JAB39973.1 414 COUP transcription factor 2 isoform a [Callithrix jacchus]
GI:14149746 GenBank JAB39974.1 414 COUP transcription factor 2 isoform a [Callithrix jacchus]
GI:14149746 RefSeq XP_005560624.1 414 PREDICTED: COUP transcription factor 2 isoform X2 [Macaca fascicularis]
GI:14149746 RefSeq XP_006984478.1 414 PREDICTED: COUP transcription factor 2-like [Peromyscus maniculatus bairdii]
GI:223555951 RefSeq XP_008050413.1 261 PREDICTED: COUP transcription factor 2 isoform X2 [Tarsius syrichta]
GI:223555951 RefSeq XP_008154687.1 261 PREDICTED: COUP transcription factor 2 isoform X2 [Eptesicus fuscus]
GI:223555951 RefSeq XP_008519606.1 261 PREDICTED: COUP transcription factor 2 [Equus przewalskii]
GI:223555949 RefSeq XP_008685840.1 281 PREDICTED: COUP transcription factor 2 [Ursus maritimus]
GI:223555949 RefSeq XP_008850566.1 281 PREDICTED: COUP transcription factor 2 isoform X2 [Nannospalax galili]
GI:223555951 RefSeq XP_008850567.1 261 PREDICTED: COUP transcription factor 2 isoform X3 [Nannospalax galili]
GI:223555949 RefSeq XP_008996594.1 281 PREDICTED: COUP transcription factor 2 isoform X2 [Callithrix jacchus]
GI:223555951 RefSeq XP_008996595.1 261 PREDICTED: COUP transcription factor 2 isoform X3 [Callithrix jacchus]
GI:223555949 RefSeq XP_009209229.1 281 PREDICTED: COUP transcription factor 2 isoform X2 [Papio anubis]
GI:223555951 RefSeq XP_009428167.1 261 PREDICTED: COUP transcription factor 2 isoform X2 [Pan troglodytes]
GI:14149746 RefSeq XP_010359627.1 414 PREDICTED: COUP transcription factor 2 isoform X1 [Rhinopithecus roxellana]
GI:223555949 RefSeq XP_010359628.1 281 PREDICTED: COUP transcription factor 2 isoform X2 [Rhinopithecus roxellana]
GI:223555949 RefSeq XP_010606175.1 281 PREDICTED: COUP transcription factor 2 [Fukomys damarensis]

Related Sequences to LMP000674 proteins

Reference Database Accession Length Protein Name
GI:223555951 DBBJ BAE24245.1 414 unnamed protein product [Mus musculus]
GI:14149746 EMBL CAB55624.1 414 COUP-TFII transcription factor [Bos taurus]
GI:223555951 GenBank AAB61297.1 414 ovalbumin upstream promoter beta nuclear receptor rCOUPb [Rattus norvegicus]
GI:14149746 GenBank AAX29860.1 415 nuclear receptor subfamily 2 group F member 2, partial [synthetic construct]
GI:14149746 GenBank AAI23678.1 414 Nuclear receptor subfamily 2, group F, member 2 [Bos taurus]
GI:223555949 GenBank AAI34736.1 281 NR2F2 protein [Bos taurus]
GI:223555951 GenBank EDM08487.1 414 nuclear receptor subfamily 2, group F, member 2, isoform CRA_a [Rattus norvegicus]
GI:223555951 RefSeq NP_542956.1 414 COUP transcription factor 2 [Rattus norvegicus]
GI:14149746 RefSeq NP_776827.1 414 COUP transcription factor 2 [Bos taurus]
GI:223555951 RefSeq XP_003901468.1 414 PREDICTED: COUP transcription factor 2 isoform X1 [Papio anubis]
GI:223555949 RefSeq XP_004617800.1 281 PREDICTED: COUP transcription factor 2 [Sorex araneus]
GI:223555949 RefSeq XP_005221767.1 281 PREDICTED: COUP transcription factor 2 isoform X2 [Bos taurus]
GI:223555949 RefSeq XP_005869977.1 281 PREDICTED: COUP transcription factor 2 isoform X1 [Myotis brandtii]
GI:223555949 RefSeq XP_006044318.1 281 PREDICTED: COUP transcription factor 2-like [Bubalus bubalis]
GI:223555949 RefSeq XP_008154686.1 281 PREDICTED: COUP transcription factor 2 isoform X1 [Eptesicus fuscus]
GI:223555951 SwissProt O09018.1 414 RecName: Full=COUP transcription factor 2; Short=COUP-TF2; AltName: Full=Apolipoprotein A-I regulatory protein 1; Short=ARP-1; AltName: Full=COUP transcription factor II; Short=COUP-TF II; AltName: Full=COUPb; AltName: Full=Nuclear receptor subfamily 2 group F member 2; AltName: Full=Ovalbumin upstream promoter beta nuclear receptor [Rattus norvegicus]
GI:14149746 SwissProt Q9TTR7.1 414 RecName: Full=COUP transcription factor 2; Short=COUP-TF2; AltName: Full=COUP transcription factor II; Short=COUP-TF II; AltName: Full=Nuclear receptor subfamily 2 group F member 2 [Bos taurus]
GI:14149746 Third Party Genbank DAA17696.1 414 TPA: COUP transcription factor 2 [Bos taurus]