Gene/Proteome Database (LMPD)

LMPD ID
LMP000679
Gene ID
76893
Species
Mus musculus (Mouse)
Gene Name
ceramide synthase 2
Gene Symbol
Cers2
Synonyms
0610013I17Rik; AI225939; Lass2; TRH3
Alternate Names
ceramide synthase 2; TRAM homolog 3; longevity assurance homolog 2; LAG1 homolog, ceramide synthase 2; LAG1 longevity assurance homolog 2; translocating chain-associating membrane protein homolog 3
Chromosome
3
Map Location
3|3 F2

Proteins

ceramide synthase 2
Refseq ID NP_084065
Protein GI 22095015
UniProt ID Q924Z4
mRNA ID NM_029789
Length 380
RefSeq Status PROVISIONAL
MLQTLYDYFWWERLWLPVNLTWADLEDKDGRVYAKASDLYITLPLALLFLVIRYFFELYVATPLAALLNVKEKTRLRAPPNATLEHFYQTSGKQPKQVEVDLLSRQSGLSGRQVERWFRRRRNQDRPSLLKKFREASWRFTYYLIAFVAGMAVTVDKPWFYDLRKVWEGYPIQSIIPSQYWYYMIELSFYWSLLFSIASDVKRKDFKEQIIHHVATIILLCFSWFANYVRAGTLIMALHDASDYLLESAKMFNYAGWKNTCNNLFIVFAIVFIITRLVIMPFWILHCTMIYPLELYPAFFGYYFFNFMMAVLQMLHIFWAYFILRMAHKFITGKLIEDERSDREETESSEGEETAAGAGAKSRLLANGHPILNNNHPKND

Gene Information

Entrez Gene ID
76893
Gene Name
ceramide synthase 2
Gene Symbol
Cers2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0031965 IEA:Ensembl C nuclear membrane
GO:0003677 IEA:UniProtKB-KW F DNA binding
GO:0050291 IDA:MGI F sphingosine N-acyltransferase activity
GO:0046513 IDA:MGI P ceramide biosynthetic process
GO:0030148 IDA:MGI P sphingolipid biosynthetic process

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY3DJ-12 ceramide biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR001356 Homeobox domain
IPR009057 Homeodomain-like
IPR016439 Longevity assurance, LAG1/LAC1
IPR006634 TRAM/LAG1/CLN8 homology domain

UniProt Annotations

Entry Information

Gene Name
ceramide synthase 2
Protein Entry
CERS2_MOUSE
UniProt ID
Q924Z4
Species
Mouse

Comments

Comment Type Description
Function Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis (By similarity). {ECO:0000250}.
Similarity Contains 1 TLC (TRAM/LAG1/CLN8) domain. {ECO:0000255|PROSITE-ProRule:PRU00205}.
Similarity Contains 1 homeobox DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00108}.
Subcellular Location Nucleus membrane {ECO:0000255|PROSITE- ProRule:PRU00108}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15823095}; Multi-pass membrane protein {ECO:0000269|PubMed:15823095}.
Subunit Interacts with ATP6V0C, ASGR1, ASGR2 and SLC22A1/OCT1. {ECO:0000250}.
Tissue Specificity Broadly expressed, with highest levels in liver and kidney. {ECO:0000269|PubMed:15823095}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000679 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
22095015 RefSeq NP_084065 380 ceramide synthase 2

Identical Sequences to LMP000679 proteins

Reference Database Accession Length Protein Name
GI:22095015 DBBJ BAE34991.1 380 unnamed protein product [Mus musculus]
GI:22095015 GenBank EDL38803.1 380 longevity assurance homolog 2 (S. cerevisiae), isoform CRA_a [Mus musculus]
GI:22095015 GenBank EDL38804.1 380 longevity assurance homolog 2 (S. cerevisiae), isoform CRA_a [Mus musculus]
GI:22095015 RefSeq XP_006502322.1 380 PREDICTED: ceramide synthase 2 isoform X1 [Mus musculus]
GI:22095015 RefSeq XP_006502323.1 380 PREDICTED: ceramide synthase 2 isoform X2 [Mus musculus]
GI:22095015 SwissProt Q924Z4.1 380 RecName: Full=Ceramide synthase 2; Short=CerS2; AltName: Full=LAG1 longevity assurance homolog 2; AltName: Full=Translocating chain-associating membrane protein homolog 3; Short=TRAM homolog 3 [Mus musculus]

Related Sequences to LMP000679 proteins

Reference Database Accession Length Protein Name
GI:22095015 GenBank EDL85715.1 380 longevity assurance homolog 2 (S. cerevisiae) [Rattus norvegicus]
GI:22095015 RefSeq NP_001028872.2 380 ceramide synthase 2 [Rattus norvegicus]
GI:22095015 RefSeq XP_003498703.1 380 PREDICTED: ceramide synthase 2 isoform X2 [Cricetulus griseus]
GI:22095015 RefSeq XP_006232949.1 380 PREDICTED: ceramide synthase 2 isoform X1 [Rattus norvegicus]
GI:22095015 RefSeq XP_006232950.1 380 PREDICTED: ceramide synthase 2 isoform X1 [Rattus norvegicus]
GI:22095015 RefSeq XP_007629477.1 380 PREDICTED: ceramide synthase 2 isoform X2 [Cricetulus griseus]