Gene/Proteome Database (LMPD)

LMPD ID
LMP000727
Gene ID
10380
Species
Homo sapiens (Human)
Gene Name
3'(2'), 5'-bisphosphate nucleotidase 1
Gene Symbol
BPNT1
Synonyms
HEL20; PIP
Chromosome
1
Map Location
1q41
EC Number
3.1.3.7
Summary
BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for BPNT1

Proteins

3'(2'),5'-bisphosphate nucleotidase 1 isoform 1
Refseq ID NP_006076
Protein GI 116812595
UniProt ID V9HWF9
mRNA ID NM_006085
Length 308
RefSeq Status VALIDATED
MASSNTVLMRLVASAYSIAQKAGMIVRRVIAEGDLGIVEKTCATDLQTKADRLAQMSICSSLARKFPKLTIIGEEDLPSEEVDQELIEDSQWEEILKQPCPSQYSAIKEEDLVVWVDPLDGTKEYTEGLLDNVTVLIGIAYEGKAIAGVINQPYYNYEAGPDAVLGRTIWGVLGLGAFGFQLKEVPAGKHIITTTRSHSNKLVTDCVAAMNPDAVLRVGGAGNKIIQLIEGKASAYVFASPGCKKWDTCAPEVILHAVGGKLTDIHGNVLQYHKDVKHMNSAGVLATLRNYDYYASRVPESIKNALVP
3'(2'),5'-bisphosphate nucleotidase 1 isoform 2
Refseq ID NP_001273080
Protein GI 555290081
UniProt ID O95861
mRNA ID NM_001286151
Length 253
RefSeq Status VALIDATED
MSICSSLARKFPKLTIIGEEDLPSEEVDQELIEDSQWEEILKQPCPSQYSAIKEEDLVVWVDPLDGTKEYTEGLLDNVTVLIGIAYEGKAIAGVINQPYYNYEAGPDAVLGRTIWGVLGLGAFGFQLKEVPAGKHIITTTRSHSNKLVTDCVAAMNPDAVLRVGGAGNKIIQLIEGKASAYVFASPGCKKWDTCAPEVILHAVGGKLTDIHGNVLQYHKDVKHMNSAGVLATLRNYDYYASRVPESIKNALVP
3'(2'),5'-bisphosphate nucleotidase 1 isoform 2
Refseq ID NP_001273078
Protein GI 555290116
UniProt ID O95861
mRNA ID NM_001286149
Length 253
RefSeq Status VALIDATED
Protein sequence is identical to GI:555290081 (mRNA isoform)
3'(2'),5'-bisphosphate nucleotidase 1 isoform 3
Refseq ID NP_001273079
Protein GI 555289990
UniProt ID O95861
mRNA ID NM_001286150
Length 272
RefSeq Status VALIDATED
MASSNTVLMRLVASAYSIAQKAGMIVRRVIAEGDLGIVEKTCATDLQTKADRLAQMSICSSLARKFPKLTIIGEELVVWVDPLDGTKEYTEGLLDNVTVLIGIAYEGKAIAGVINQPYYNYEAGPDAVLGRTIWGVLGLGAFGFQLKEVPAGKHIITTTRSHSNKLVTDCVAAMNPDAVLRVGGAGNKIIQLIEGKASAYVFASPGCKKWDTCAPEVILHAVGGKLTDIHGNVLQYHKDVKHMNSAGVLATLRNYDYYASRVPESIKNALVP

Gene Information

Entrez Gene ID
10380
Gene Name
3'(2'), 5'-bisphosphate nucleotidase 1
Gene Symbol
BPNT1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 TAS:Reactome C cytosol
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0008441 TAS:ProtInc F 3'(2'),5'-bisphosphate nucleotidase activity
GO:0004441 IEA:Ensembl F inositol-1,4-bisphosphate 1-phosphatase activity
GO:0000287 IEA:Ensembl F magnesium ion binding
GO:0050427 TAS:Reactome P 3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO:0016311 TAS:GOC P dephosphorylation
GO:0007399 TAS:ProtInc P nervous system development
GO:0006139 TAS:ProtInc P nucleobase-containing compound metabolic process
GO:0046854 IEA:InterPro P phosphatidylinositol phosphorylation
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0006805 TAS:Reactome P xenobiotic metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa01100 Metabolic pathways
hsa00920 Sulfur metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_6913 Cytosolic sulfonation of small molecules
REACT_6959 Phase II conjugation

Domain Information

InterPro Annotations

Accession Description
IPR020550 Inositol monophosphatase, conserved site
IPR020583 Inositol monophosphatase, metal-binding site
IPR000760 Inositol_monophosphatase

UniProt Annotations

Entry Information

Gene Name
3'(2'), 5'-bisphosphate nucleotidase 1
Protein Entry
BPNT1_HUMAN
UniProt ID
V9HWF9
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=O95861-1; Sequence=Displayed; Name=2; IsoId=O95861-2; Sequence=VSP_009937; Note=No experimental confirmation available.; Name=3; IsoId=O95861-3; Sequence=VSP_054807; Name=4; IsoId=O95861-4; Sequence=VSP_054808;
Catalytic Activity Adenosine 3',5'-bisphosphate + H(2)O = adenosine 5'-phosphate + phosphate.
Cofactor Name=Mg(2+); Xref=ChEBI
Enzyme Regulation Uncompetitive inhibition by micromolar concentrations of lithium. Competitive inhibition by inositol 1,4- bisphosphate.
Function Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4- trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6.
Similarity Belongs to the inositol monophosphatase family.
Tissue Specificity Highly expressed in kidney, liver, pancreas and heart. Detected at lower levels in brain, placenta, lung and skeletal muscle.

Identical and Related Proteins

Unique RefSeq proteins for LMP000727 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
116812595 RefSeq NP_006076 308 3'(2'),5'-bisphosphate nucleotidase 1 isoform 1
555290081 RefSeq NP_001273080 253 3'(2'),5'-bisphosphate nucleotidase 1 isoform 2
555289990 RefSeq NP_001273079 272 3'(2'),5'-bisphosphate nucleotidase 1 isoform 3

Identical Sequences to LMP000727 proteins

Reference Database Accession Length Protein Name
GI:555289990 DBBJ BAG62441.1 272 unnamed protein product [Homo sapiens]
GI:555290081 DBBJ BAG60687.1 253 unnamed protein product [Homo sapiens]
GI:116812595 GenBank JAA17705.1 308 3'(2'), 5'-bisphosphate nucleotidase 1 [Pan troglodytes]
GI:116812595 GenBank JAA17706.1 308 3'(2'), 5'-bisphosphate nucleotidase 1 [Pan troglodytes]
GI:116812595 GenBank JAA25927.1 308 3'(2'), 5'-bisphosphate nucleotidase 1 [Pan troglodytes]
GI:116812595 GenBank JAA25928.1 308 3'(2'), 5'-bisphosphate nucleotidase 1 [Pan troglodytes]
GI:555289990 RefSeq XP_002809487.1 272 PREDICTED: 3'(2'),5'-bisphosphate nucleotidase 1 isoform X2 [Pongo abelii]
GI:555289990 RefSeq XP_003807232.1 272 PREDICTED: 3'(2'),5'-bisphosphate nucleotidase 1 isoform X4 [Pan paniscus]
GI:116812595 RefSeq XP_005273057.1 308 PREDICTED: 3'(2'),5'-bisphosphate nucleotidase 1 isoform X3 [Homo sapiens]
GI:555290081 RefSeq NP_001273078.1 253 3'(2'),5'-bisphosphate nucleotidase 1 isoform 2 [Homo sapiens]
GI:116812595 RefSeq XP_009235846.1 308 PREDICTED: 3'(2'),5'-bisphosphate nucleotidase 1 isoform X1 [Pongo abelii]

Related Sequences to LMP000727 proteins

Reference Database Accession Length Protein Name
GI:555290081 DBBJ BAF84632.1 308 unnamed protein product [Homo sapiens]
GI:116812595 EMBL CAB65115.1 308 PAP-inositol-1,4-phosphatase [Homo sapiens]
GI:555290081 GenBank EAW93306.1 308 3'(2'), 5'-bisphosphate nucleotidase 1, isoform CRA_a [Homo sapiens]
GI:555290081 GenBank EAW93308.1 308 3'(2'), 5'-bisphosphate nucleotidase 1, isoform CRA_a [Homo sapiens]
GI:116812595 GenBank JAA34444.1 352 3'(2'), 5'-bisphosphate nucleotidase 1 [Pan troglodytes]
GI:116812595 RefSeq XP_001172472.1 366 PREDICTED: 3'(2'),5'-bisphosphate nucleotidase 1 isoform X3 [Pan troglodytes]
GI:116812595 RefSeq XP_003308798.1 352 PREDICTED: 3'(2'),5'-bisphosphate nucleotidase 1 isoform X4 [Pan troglodytes]
GI:555290081 RefSeq XP_003807231.1 308 PREDICTED: 3'(2'),5'-bisphosphate nucleotidase 1 isoform X2 [Pan paniscus]
GI:555289990 RefSeq XP_003949746.1 316 PREDICTED: 3'(2'),5'-bisphosphate nucleotidase 1 isoform X8 [Pan troglodytes]
GI:116812595 RefSeq XP_004028470.1 352 PREDICTED: 3'(2'),5'-bisphosphate nucleotidase 1 isoform 1 [Gorilla gorilla gorilla]
GI:116812595 RefSeq XP_004028471.1 367 PREDICTED: 3'(2'),5'-bisphosphate nucleotidase 1 isoform 2 [Gorilla gorilla gorilla]
GI:555289990 RefSeq XP_004028472.1 316 PREDICTED: 3'(2'),5'-bisphosphate nucleotidase 1 isoform 3 [Gorilla gorilla gorilla]
GI:555289990 RefSeq XP_006711177.1 287 PREDICTED: 3'(2'),5'-bisphosphate nucleotidase 1 isoform X9 [Homo sapiens]
GI:555289990 RefSeq XP_008957485.1 287 PREDICTED: 3'(2'),5'-bisphosphate nucleotidase 1 isoform X3 [Pan paniscus]
GI:555290081 RefSeq XP_009235846.1 308 PREDICTED: 3'(2'),5'-bisphosphate nucleotidase 1 isoform X1 [Pongo abelii]
GI:555289990 RefSeq XP_009439786.1 330 PREDICTED: 3'(2'),5'-bisphosphate nucleotidase 1 isoform X6 [Pan troglodytes]
GI:555289990 RefSeq XP_010339340.1 272 PREDICTED: 3'(2'),5'-bisphosphate nucleotidase 1 [Saimiri boliviensis boliviensis]
GI:555290081 SwissProt O95861.1 308 RecName: Full=3'(2'),5'-bisphosphate nucleotidase 1; AltName: Full=Bisphosphate 3'-nucleotidase 1; AltName: Full=PAP-inositol 1,4-phosphatase; Short=PIP [Homo sapiens]