Gene/Proteome Database (LMPD)

LMPD ID
LMP000746
Gene ID
26394
Species
Mus musculus (Mouse)
Gene Name
lysophospholipase 2
Gene Symbol
Lypla2
Synonyms
LysoII
Alternate Names
acyl-protein thioesterase 2; APT-2; LPL-II; mLyso II; lysoPLA II; lysophospholipase II
Chromosome
4
Map Location
4 D3|4
EC Number
3.1.2.-

Proteins

acyl-protein thioesterase 2
Refseq ID NP_036072
Protein GI 7242156
UniProt ID Q9WTL7
mRNA ID NM_011942
Length 231
RefSeq Status PROVISIONAL
MCGNTMSVPLLTDAATVSGAERETAAVIFLHGLGDTGHSWADALSTIRLPHVKYICPHAPRIPVTLNMKMVMPSWFDLMGLSPDAPEDEAGIKKAAENIKALIEHEMKNGIPANRIVLGGFSQGGALSLYTALTCPHPLAGIVALSCWLPLHRNFPQAANGSAKDLAILQCHGELDPMVPVRFGALTAEKLRTVVTPARVQFKTYPGVMHSSCPQEMAAVKEFLEKLLPPV

Gene Information

Entrez Gene ID
26394
Gene Name
lysophospholipase 2
Gene Symbol
Lypla2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0016787 IEA:UniProtKB-KW F hydrolase activity
GO:0006631 IEA:UniProtKB-KW P fatty acid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00564 Glycerophospholipid metabolism
mmu00564 Glycerophospholipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR003140 Phospholipase/carboxylesterase/thioesterase

UniProt Annotations

Entry Information

Gene Name
lysophospholipase 2
Protein Entry
LYPA2_MOUSE
UniProt ID
Q9WTL7
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Palmitoyl-protein + H(2)O = palmitate + protein.
Function May hydrolyze fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Deacylates GAP43 (By similarity). Has lysophospholipase activity. {ECO:0000250, ECO:0000269|PubMed:10064901}.
Similarity Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. {ECO:0000305}.
Subcellular Location Cytoplasm {ECO:0000305}.
Tissue Specificity Ubiquitous; detected at low levels. {ECO:0000269|PubMed:10064901}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000746 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
7242156 RefSeq NP_036072 231 acyl-protein thioesterase 2

Identical Sequences to LMP000746 proteins

Reference Database Accession Length Protein Name
GI:7242156 DBBJ BAC40757.1 231 unnamed protein product [Mus musculus]
GI:7242156 DBBJ BAE39559.1 231 unnamed protein product [Mus musculus]
GI:7242156 GenBank AAH68120.1 231 Lysophospholipase 2 [Mus musculus]
GI:7242156 GenBank EDL29957.1 231 lysophospholipase 2, isoform CRA_a [Mus musculus]
GI:7242156 GenBank EDL29958.1 231 lysophospholipase 2, isoform CRA_a [Mus musculus]
GI:7242156 SwissProt Q9WTL7.1 231 RecName: Full=Acyl-protein thioesterase 2; Short=APT-2; AltName: Full=Lysophospholipase 2; AltName: Full=Lysophospholipase II; Short=LPL-II; Short=LysoPLA II; Short=mLyso II [Mus musculus]

Related Sequences to LMP000746 proteins

Reference Database Accession Length Protein Name
GI:7242156 GenBank EDL80788.1 231 lysophospholipase 2, isoform CRA_a [Rattus norvegicus]
GI:7242156 GenBank EDL80789.1 231 lysophospholipase 2, isoform CRA_a [Rattus norvegicus]
GI:7242156 RefSeq XP_005317651.1 231 PREDICTED: acyl-protein thioesterase 2 [Ictidomys tridecemlineatus]
GI:7242156 RefSeq XP_006538940.1 356 PREDICTED: acyl-protein thioesterase 2 isoform X1 [Mus musculus]
GI:7242156 RefSeq XP_008846820.1 231 PREDICTED: acyl-protein thioesterase 2 [Nannospalax galili]
GI:7242156 SwissProt Q9QYL8.1 231 RecName: Full=Acyl-protein thioesterase 2; Short=APT-2; AltName: Full=Lysophospholipase 2; AltName: Full=Lysophospholipase II; Short=LPL-II; Short=LysoPLA II [Rattus norvegicus]