Gene/Proteome Database (LMPD)

LMPD ID
LMP000782
Gene ID
12091
Species
Mus musculus (Mouse)
Gene Name
galactosidase, beta 1
Gene Symbol
Glb1
Synonyms
AW125515; Bge; Bgl; Bgl-e; Bgl-s; Bgl-t; Bgs; Bgt; C130097A14Rik
Alternate Names
beta-galactosidase; lactase; acid beta-galactosidase
Chromosome
9
Map Location
9 F3|9 64.4 cM
EC Number
3.2.1.23
Summary
This gene encodes a preproprotein that is proteolytically cleaved to yield a signal peptide and a proproptein that is subsequently processed to generate the active mature peptide. The encoded protein is a lysosomal enzyme that catalyzes the hydrolysis of terminal beta-D-galactose residues in various substrates like lactose, ganglioside GM1 and other glycoproteins. Mutations in the human gene are associated with GM1-gangliosidosis and Morquio B syndrome. Disruption of the mouse gene mirrors the symptoms of human gangliosidosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Orthologs
View orthologs and multiple alignments for Glb1

Proteins

beta-galactosidase preproprotein
Refseq ID NP_033882
Protein GI 6753190
UniProt ID P23780
mRNA ID NM_009752
Length 647
RefSeq Status REVIEWED
MLRVPLCTPLPLLALLQLLGAAHGIYNVTQRTFKLDYSRDRFLKDGQPFRYISGSIHYFRIPRFYWEDRLLKMKMAGLNAIQMYVPWNFHEPQPGQYEFSGDRDVEHFIQLAHELGLLVILRPGPYICAEWDMGGLPAWLLEKQSIVLRSSDPDYLVAVDKWLAVLLPKMKPLLYQNGGPIITVQVENEYGSYFACDYDYLRFLVHRFRYHLGNDVILFTTDGASEKMLKCGTLQDLYATVDFGTGNNITQAFLVQRKFEPKGPLINSEFYTGWLDHWGKPHSTVKTKTLATSLYNLLARGANVNLYMFIGGTNFAYWNGANTPYEPQPTSYDYDAPLSEAGDLTKKYFALREVIQMFKEVPEGPIPPSTPKFAYGKVALRKFKTVAEALGILCPNGPVKSLYPLTFTQVKQYFGYVLYRTTLPQDCSNPKPIFSSPFNGVRDRAYVSVDGVPQGILDRNLMTALNIRGKAGATLDILVENMGRVNYGRFINDFKGLISNMTINSTVLTNWTVFPLNTEAMVRNHLWGREASDEGHLDGRSTSNSSDLILPTFYVGNFSIPSGIPDLPQDTFIQFPGWSKGQVWINGFNLGRYWPTMGPQKTLFVPRNILTTSAPNNITVLELEFAPCSEGTPELCTVEFVDTPVIS
sig_peptide: 1..24 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2511 peptide sequence: MLRVPLCTPLPLLALLQLLGAAHG mat_peptide: 30..647 product: Beta-galactosidase experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P23780.1) calculated_mol_wt: 70038 peptide sequence: QRTFKLDYSRDRFLKDGQPFRYISGSIHYFRIPRFYWEDRLLKMKMAGLNAIQMYVPWNFHEPQPGQYEFSGDRDVEHFIQLAHELGLLVILRPGPYICAEWDMGGLPAWLLEKQSIVLRSSDPDYLVAVDKWLAVLLPKMKPLLYQNGGPIITVQVENEYGSYFACDYDYLRFLVHRFRYHLGNDVILFTTDGASEKMLKCGTLQDLYATVDFGTGNNITQAFLVQRKFEPKGPLINSEFYTGWLDHWGKPHSTVKTKTLATSLYNLLARGANVNLYMFIGGTNFAYWNGANTPYEPQPTSYDYDAPLSEAGDLTKKYFALREVIQMFKEVPEGPIPPSTPKFAYGKVALRKFKTVAEALGILCPNGPVKSLYPLTFTQVKQYFGYVLYRTTLPQDCSNPKPIFSSPFNGVRDRAYVSVDGVPQGILDRNLMTALNIRGKAGATLDILVENMGRVNYGRFINDFKGLISNMTINSTVLTNWTVFPLNTEAMVRNHLWGREASDEGHLDGRSTSNSSDLILPTFYVGNFSIPSGIPDLPQDTFIQFPGWSKGQVWINGFNLGRYWPTMGPQKTLFVPRNILTTSAPNNITVLELEFAPCSEGTPELCTVEFVDTPVIS

Gene Information

Entrez Gene ID
12091
Gene Name
galactosidase, beta 1
Gene Symbol
Glb1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:Ensembl C Golgi apparatus
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005764 IEA:UniProtKB-KW C lysosome
GO:0004565 IDA:MGI F beta-galactosidase activity
GO:0016936 IEA:Ensembl F galactoside binding
GO:0019388 IEA:Ensembl P galactose catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu04142 Lysosome
mmu00600 Sphingolipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5893995 Glycosphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR026283 Beta-galactosidase 1-like
IPR008979 Galactose-binding domain-like
IPR017853 Glycoside hydrolase superfamily
IPR013781 Glycoside hydrolase, catalytic domain
IPR001944 Glycoside hydrolase, family 35
IPR019801 Glycoside hydrolase, family 35, conserved site

UniProt Annotations

Entry Information

Gene Name
galactosidase, beta 1
Protein Entry
BGAL_MOUSE
UniProt ID
P23780
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Hydrolysis of terminal non-reducing beta-D- galactose residues in beta-D-galactosides.
Function Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.
Similarity Belongs to the glycosyl hydrolase 35 family. {ECO:0000305}.
Subcellular Location Lysosome.

Identical and Related Proteins

Unique RefSeq proteins for LMP000782 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6753190 RefSeq NP_033882 647 beta-galactosidase preproprotein

Identical Sequences to LMP000782 proteins

Reference Database Accession Length Protein Name
GI:6753190 DBBJ BAE42549.1 647 unnamed protein product [Mus musculus]
GI:6753190 GenBank AAA37293.1 647 beta-galactosidase [Mus musculus]
GI:6753190 SwissProt P23780.1 647 RecName: Full=Beta-galactosidase; AltName: Full=Acid beta-galactosidase; Short=Lactase; Flags: Precursor [Mus musculus]

Related Sequences to LMP000782 proteins

Reference Database Accession Length Protein Name
GI:6753190 DBBJ BAC33344.1 756 unnamed protein product [Mus musculus]
GI:6753190 DBBJ BAC36375.1 682 unnamed protein product, partial [Mus musculus]
GI:6753190 GenBank AAA37292.1 647 acid beta-galactosidase [Mus musculus]
GI:6753190 GenBank AAH28875.1 647 Galactosidase, beta 1 [Mus musculus]
GI:6753190 GenBank EDL09311.1 647 galactosidase, beta 1, isoform CRA_c [Mus musculus]
GI:6753190 RefSeq NP_001101662.1 647 beta-galactosidase precursor [Rattus norvegicus]