Gene/Proteome Database (LMPD)

LMPD ID
LMP000867
Gene ID
19015
Species
Mus musculus (Mouse)
Gene Name
peroxisome proliferator activator receptor delta
Gene Symbol
Ppard
Synonyms
NUC-1; NUC1; Nr1c2; PPAR-beta; PPAR-delta; PPAR[b]; PPARdelta; Pparb; Pparb/d
Alternate Names
peroxisome proliferator-activated receptor delta; PPARdelta/beta; nuclear hormone receptor 1; nuclear receptor subfamily 1 group C member 2; Peroxisome proliferator-activated receptor beta
Chromosome
17
Map Location
17 A3.3|17 14.64 cM

Proteins

peroxisome proliferator-activated receptor delta
Refseq ID NP_035275
Protein GI 33859590
UniProt ID P35396
mRNA ID NM_011145
Length 440
RefSeq Status VALIDATED
MEQPQEETPEAREEEKEEVAMGDGAPELNGGPEHTLPSSSCADLSQNSSPSSLLDQLQMGCDGASGGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCDRICKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTASEGCQHNPQLADLKAFSKHIYNAYLKNFNMTKKKARSILTGKSSHNAPFVIHDIETLWQAEKGLVWKQLVNGLPPYNEISVHVFYRCQSTTVETVRELTEFAKNIPNFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTHEFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPQVEAIQDTILRALEFHLQVNHPDSQYLFPKLLQKMADLRQLVTEHAQMMQWLKKTESETLLHPLLQEIYKDMY

Gene Information

Entrez Gene ID
19015
Gene Name
peroxisome proliferator activator receptor delta
Gene Symbol
Ppard
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0003677 IDA:MGI F DNA binding
GO:0008144 ISS:UniProtKB F drug binding
GO:0008047 TAS:UniProtKB F enzyme activator activity
GO:0004879 ISS:UniProtKB F ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0070539 ISS:UniProtKB F linoleic acid binding
GO:0008289 ISS:UniProtKB F lipid binding
GO:0016501 TAS:UniProtKB F prostacyclin receptor activity
GO:0046982 TAS:UniProtKB F protein heterodimerization activity
GO:0046965 TAS:UniProtKB F retinoid X receptor binding
GO:0043565 IEA:InterPro F sequence-specific DNA binding
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0003713 IEA:Ensembl F transcription coactivator activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0007186 TAS:GOC P G-protein coupled receptor signaling pathway
GO:0060612 IMP:MGI P adipose tissue development
GO:0042640 IMP:MGI P anagen
GO:0097190 IEA:Ensembl P apoptotic signaling pathway
GO:0008366 IMP:MGI P axon ensheathment
GO:0030154 IDA:MGI P cell differentiation
GO:0008283 IMP:MGI P cell proliferation
GO:0031589 IMP:MGI P cell-substrate adhesion
GO:0009987 TAS:MGI P cellular process
GO:0071456 IGI:MGI P cellular response to hypoxia
GO:0046697 IEA:Ensembl P decidualization
GO:0007566 TAS:UniProtKB P embryo implantation
GO:0008544 TAS:MGI P epidermis development
GO:0006635 IEP:UniProtKB P fatty acid beta-oxidation
GO:0015908 IEP:UniProtKB P fatty acid transport
GO:0007507 IEA:Ensembl P heart development
GO:0030522 ISS:GOC P intracellular receptor signaling pathway
GO:0051546 IMP:MGI P keratinocyte migration
GO:0043616 IMP:MGI P keratinocyte proliferation
GO:0006629 IMP:MGI P lipid metabolic process
GO:0009299 IEA:Ensembl P mRNA transcription
GO:0043066 IEA:Ensembl P negative regulation of apoptotic process
GO:0030308 IEA:Ensembl P negative regulation of cell growth
GO:0032966 IEA:Ensembl P negative regulation of collagen biosynthetic process
GO:0050680 IGI:MGI P negative regulation of epithelial cell proliferation
GO:0050728 IEA:Ensembl P negative regulation of inflammatory response
GO:0014912 IEA:Ensembl P negative regulation of smooth muscle cell migration
GO:0048662 IEA:Ensembl P negative regulation of smooth muscle cell proliferation
GO:0000122 IDA:MGI P negative regulation of transcription from RNA polymerase II promoter
GO:0008654 IEA:Ensembl P phospholipid biosynthetic process
GO:0001890 IMP:MGI P placenta development
GO:0043085 TAS:GOC P positive regulation of catalytic activity
GO:0008284 IMP:MGI P positive regulation of cell proliferation
GO:0045684 IEA:Ensembl P positive regulation of epidermis development
GO:0032024 IEA:Ensembl P positive regulation of insulin secretion
GO:0014068 IDA:MGI P positive regulation of phosphatidylinositol 3-kinase signaling
GO:0045893 ISS:UniProtKB P positive regulation of transcription, DNA-templated
GO:0045909 IEA:Ensembl P positive regulation of vasodilation
GO:0006029 IEA:Ensembl P proteoglycan metabolic process
GO:0042127 IGI:MGI P regulation of cell proliferation
GO:0045598 IMP:MGI P regulation of fat cell differentiation
GO:0050796 NAS:UniProtKB P regulation of insulin secretion
GO:0014823 IEA:Ensembl P response to activity
GO:0009749 IEA:Ensembl P response to glucose
GO:0033189 IEA:Ensembl P response to vitamin A
GO:0006776 IEA:Ensembl P vitamin A metabolic process
GO:0042060 IMP:MGI P wound healing

KEGG Pathway Links

KEGG Pathway ID Description
mmu05221 Acute myeloid leukemia

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR003074 Peroxisome proliferator-activated receptor
IPR003075 Peroxisome proliferator-activated receptor, beta
IPR001723 Steroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
peroxisome proliferator activator receptor delta
Protein Entry
PPARD_MOUSE
UniProt ID
P35396
Species
Mouse

Comments

Comment Type Description
Function Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand (By similarity). {ECO:0000250}.
Sequence Caution Sequence=AAA03332.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Belongs to the nuclear hormone receptor family. NR1 subfamily. {ECO:0000305}.
Similarity Contains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}.
Subcellular Location Nucleus.
Subunit Heterodimer with the retinoid X receptor.
Tissue Specificity Heart, adrenal and intestine.

Identical and Related Proteins

Unique RefSeq proteins for LMP000867 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
33859590 RefSeq NP_035275 440 peroxisome proliferator-activated receptor delta

Identical Sequences to LMP000867 proteins

Reference Database Accession Length Protein Name
GI:33859590 EMBL CAD44517.1 440 peroxisome proliferator activated receptor beta/delta [Mus musculus]
GI:33859590 GenBank AAA63394.1 440 peroxisome proliferator-activated receptor [Mus musculus domesticus]
GI:33859590 GenBank AAH70398.1 440 Peroxisome proliferator activator receptor delta [Mus musculus]
GI:33859590 RefSeq XP_006523922.1 440 PREDICTED: peroxisome proliferator-activated receptor delta isoform X1 [Mus musculus]
GI:33859590 RefSeq XP_006536796.1 440 PREDICTED: peroxisome proliferator-activated receptor delta isoform X1 [Mus musculus]
GI:33859590 SwissProt P35396.1 440 RecName: Full=Peroxisome proliferator-activated receptor delta; Short=PPAR-delta; AltName: Full=Nuclear hormone receptor 1; Short=NUC1; AltName: Full=Nuclear receptor subfamily 1 group C member 2; AltName: Full=Peroxisome proliferator-activated receptor beta; Short=PPAR-beta [Mus musculus]

Related Sequences to LMP000867 proteins

Reference Database Accession Length Protein Name
GI:33859590 GenBank AAA19972.1 440 peroxisome proliferator-activated receptor delta [Mus musculus]
GI:33859590 GenBank AAT13872.1 440 Sequence 14 from patent US 6696473
GI:33859590 GenBank ABJ48134.1 440 Sequence 14 from patent US 7115640
GI:33859590 GenBank ACN04141.1 440 Sequence 26 from patent US 7482366
GI:33859590 GenBank AEN39530.1 440 Sequence 14 from patent US 7998986
GI:33859590 GenBank AEP73965.1 440 Sequence 26 from patent US 8013001