Gene/Proteome Database (LMPD)

LMPD ID
LMP000875
Gene ID
58861
Species
Mus musculus (Mouse)
Gene Name
cysteinyl leukotriene receptor 1
Gene Symbol
Cysltr1
Synonyms
BB147369; CysLT1R; Cyslt1
Alternate Names
cysteinyl leukotriene receptor 1; LTD4 receptor; cysteinyl leukotriene D4 receptor; cysteinyl leukotriene 1 receptor short isoform
Chromosome
X
Map Location
X|X D

Proteins

cysteinyl leukotriene receptor 1 isoform a
Refseq ID NP_067451
Protein GI 31542449
UniProt ID Q99JA4
mRNA ID NM_021476
Length 352
RefSeq Status VALIDATED
MYLQGTKQTFLENMNGTENLTTSLINNTCHDTIDEFRNQVYSTMYSVISVVGFFGNSFVLYVLIKTYHEKSAFQVYMINLAIADLLCVCTLPLRVVYYVHKGKWLFGDFLCRLTTYALYVNLYCSIFFMTAMSFFRCVAIVFPVQNINLVTQKKARFVCIGIWIFVILTSSPFLMYKSYQDEKNNTKCFEPPQNNQAKKYVLILHYVSLFFGFIIPFVTIIVCYTMIILTLLKNTMKKNMPSRRKAIGMIIVVTAAFLVSFMPYHIQRTIHLHLLHSETRPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRRRLSTFRKHSLSSMTYVPKKKASLPEKGEEICNE
cysteinyl leukotriene receptor 1 isoform a
Refseq ID NP_001268788
Protein GI 530230387
UniProt ID Q99JA4
mRNA ID NM_001281859
Length 352
RefSeq Status VALIDATED
Protein sequence is identical to GI:31542449 (mRNA isoform)
cysteinyl leukotriene receptor 1 isoform b
Refseq ID NP_001268791
Protein GI 530230714
UniProt ID Q99JA4
mRNA ID NM_001281862
Length 339
RefSeq Status VALIDATED
MNGTENLTTSLINNTCHDTIDEFRNQVYSTMYSVISVVGFFGNSFVLYVLIKTYHEKSAFQVYMINLAIADLLCVCTLPLRVVYYVHKGKWLFGDFLCRLTTYALYVNLYCSIFFMTAMSFFRCVAIVFPVQNINLVTQKKARFVCIGIWIFVILTSSPFLMYKSYQDEKNNTKCFEPPQNNQAKKYVLILHYVSLFFGFIIPFVTIIVCYTMIILTLLKNTMKKNMPSRRKAIGMIIVVTAAFLVSFMPYHIQRTIHLHLLHSETRPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRRRLSTFRKHSLSSMTYVPKKKASLPEKGEEICNE

Gene Information

Entrez Gene ID
58861
Gene Name
cysteinyl leukotriene receptor 1
Gene Symbol
Cysltr1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005887 IDA:MGI C integral component of plasma membrane
GO:0004974 IDA:MGI F leukotriene receptor activity
GO:0006816 IDA:MGI P calcium ion transport
GO:0007166 IDA:MGI P cell surface receptor signaling pathway
GO:0006935 IDA:MGI P chemotaxis
GO:0006954 IEA:Ensembl P inflammatory response
GO:0045766 IEA:Ensembl P positive regulation of angiogenesis
GO:0045907 IEA:Ensembl P positive regulation of vasoconstriction

KEGG Pathway Links

KEGG Pathway ID Description
mmu04020 Calcium signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR004071 Cysteinyl leukotriene receptor
IPR013310 Cysteinyl leukotriene receptor 1
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM

UniProt Annotations

Entry Information

Gene Name
cysteinyl leukotriene receptor 1
Protein Entry
CLTR1_MOUSE
UniProt ID
Q99JA4
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Long; IsoId=Q99JA4-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q99JA4-2; Sequence=VSP_001921;
Function Receptor for cysteinyl leukotrienes mediating constriction of the microvascular smooth muscle during an inflammatory response. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.
Miscellaneous MK-571, a selective antagonist, was shown to inhibit eosinophilia, bronchial hyperreactivity and microvascular leakage. Zafirlukast (Accolate) and pranlukast (Onon) were also shown to be selective antagonists.
Similarity Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Widely expressed, with higher expression in the lung and skin, intermediate levels in the heart, kidney and stomach and lower levels in several other tissues. Isoform 1 is the most abundant form in all tested tissues.

Identical and Related Proteins

Unique RefSeq proteins for LMP000875 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
31542449 RefSeq NP_067451 352 cysteinyl leukotriene receptor 1 isoform a
530230714 RefSeq NP_001268791 339 cysteinyl leukotriene receptor 1 isoform b

Identical Sequences to LMP000875 proteins

Reference Database Accession Length Protein Name
GI:530230714 DBBJ BAA96809.1 339 CysLT1 [Mus musculus]
GI:31542449 DBBJ BAC28308.1 352 unnamed protein product [Mus musculus]
GI:530230714 GenBank AAK16716.1 339 cysteinyl leukotriene 1 receptor short isoform [Mus musculus]
GI:31542449 GenBank AAH27102.1 352 Cysteinyl leukotriene receptor 1 [Mus musculus]
GI:31542449 GenBank EDL14049.1 352 cysteinyl leukotriene receptor 1, isoform CRA_a [Mus musculus]
GI:31542449 GenBank EDL14050.1 352 cysteinyl leukotriene receptor 1, isoform CRA_a [Mus musculus]
GI:31542449 RefSeq NP_001268788.1 352 cysteinyl leukotriene receptor 1 isoform a [Mus musculus]
GI:530230714 RefSeq XP_006528275.1 339 PREDICTED: cysteinyl leukotriene receptor 1 isoform X1 [Mus musculus]
GI:31542449 SwissProt Q99JA4.1 352 RecName: Full=Cysteinyl leukotriene receptor 1; Short=CysLTR1; AltName: Full=Cysteinyl leukotriene D4 receptor; Short=LTD4 receptor [Mus musculus]

Related Sequences to LMP000875 proteins

Reference Database Accession Length Protein Name
GI:31542449 DBBJ BAA96809.1 339 CysLT1 [Mus musculus]
GI:530230714 DBBJ BAC28308.1 352 unnamed protein product [Mus musculus]
GI:31542449 GenBank AAF73047.1 352 leukotriene D4 receptor [Mus musculus]
GI:530230714 GenBank AAK16715.1 352 cysteinyl leukotriene 1 receptor long isoform [Mus musculus]
GI:31542449 GenBank AAK16716.1 339 cysteinyl leukotriene 1 receptor short isoform [Mus musculus]
GI:530230714 GenBank EDL14049.1 352 cysteinyl leukotriene receptor 1, isoform CRA_a [Mus musculus]
GI:530230714 GenBank EDL14050.1 352 cysteinyl leukotriene receptor 1, isoform CRA_a [Mus musculus]
GI:31542449 GenBank EDM07131.1 352 rCG37983, isoform CRA_a [Rattus norvegicus]
GI:530230714 RefSeq NP_067451.2 352 cysteinyl leukotriene receptor 1 isoform a [Mus musculus]
GI:530230714 RefSeq NP_001268788.1 352 cysteinyl leukotriene receptor 1 isoform a [Mus musculus]
GI:31542449 RefSeq NP_001268791.1 339 cysteinyl leukotriene receptor 1 isoform b [Mus musculus]
GI:31542449 RefSeq XP_006528275.1 339 PREDICTED: cysteinyl leukotriene receptor 1 isoform X1 [Mus musculus]