Gene/Proteome Database (LMPD)

LMPD ID
LMP001019
Gene ID
22236
Species
Mus musculus (Mouse)
Gene Name
UDP glucuronosyltransferase 1 family, polypeptide A2
Gene Symbol
Ugt1a2
Synonyms
UDPGT 1-2; Ugt1
Alternate Names
UDP-glucuronosyltransferase 1-2; UDPGT; UGT1*0; UGT1.2; UGT1-02; bilirubin specific; bilirubin-specific UDPGT; UDP-glucuronosyltransferase 1A2; UDP-glucuronosyltransferase 1 family, member 2; UDP-glucuronosyltransferase 1 family, polypeptide A2
Chromosome
1
Map Location
1 D|1
EC Number
2.4.1.17

Proteins

UDP-glucuronosyltransferase 1-2 precursor
Refseq ID NP_038729
Protein GI 32526871
UniProt ID P70691
mRNA ID NM_013701
Length 533
RefSeq Status VALIDATED
MDTGLCVPLRGISGLLLLLCALPWAEGAKVLVLPMEGSQWLSMRDVVRELHARGHQTVVLASEVTVHIKGEDFFTLKTYAFPYTKEEYQQEILSDIEKTFKTQHFVKAFFETTASIRNFFDLYSNSCIALLHNKMLIQQLNSSFFDVILTDPIFPCGAVLAKYLQIPAVFILRSLSCGIEYEATQCPNPSSYIPNLLTRLSDHMDFLQRVQNMLYYLVLKYICRLSITPYESLASELLQREVSLVEVLSHASVWLFRGDFVLDYPRPIMPNMVFIGGINCVTKKPLSQEFEAYVNASGEHGIVVFSLGSMVSEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVFKCCAYGCRKCFGGKGRVKKSHKSKTH
sig_peptide: 1..27 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2812 peptide sequence: MDTGLCVPLRGISGLLLLLCALPWAEG mat_peptide: 28..533 product: UDP-glucuronosyltransferase 1-2 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P70691.1) calculated_mol_wt: 57491 peptide sequence: AKVLVLPMEGSQWLSMRDVVRELHARGHQTVVLASEVTVHIKGEDFFTLKTYAFPYTKEEYQQEILSDIEKTFKTQHFVKAFFETTASIRNFFDLYSNSCIALLHNKMLIQQLNSSFFDVILTDPIFPCGAVLAKYLQIPAVFILRSLSCGIEYEATQCPNPSSYIPNLLTRLSDHMDFLQRVQNMLYYLVLKYICRLSITPYESLASELLQREVSLVEVLSHASVWLFRGDFVLDYPRPIMPNMVFIGGINCVTKKPLSQEFEAYVNASGEHGIVVFSLGSMVSEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVFKCCAYGCRKCFGGKGRVKKSHKSKTH

Gene Information

Entrez Gene ID
22236
Gene Name
UDP glucuronosyltransferase 1 family, polypeptide A2
Gene Symbol
Ugt1a2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0015020 IEA:UniProtKB-EC F glucuronosyltransferase activity

KEGG Pathway Links

KEGG Pathway ID Description
mmu05204 Chemical carcinogenesis
mmu00140 Steroid hormone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase

UniProt Annotations

Entry Information

Gene Name
UDP glucuronosyltransferase 1 family, polypeptide A2
Protein Entry
UD12_MOUSE
UniProt ID
P70691
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=1; Comment=A number of isoforms are produced. The different isozymes have a different N-terminal domain and a common C-terminal domain of 245 residues.; Name=1; IsoId=P70691-1; Sequence=Displayed;
Catalytic Activity UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Function UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
Similarity Belongs to the UDP-glycosyltransferase family. {ECO:0000305}.
Subcellular Location Microsome {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Tissue Specificity Expressed in kidney. {ECO:0000269|PubMed:14672974}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001019 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
32526871 RefSeq NP_038729 533 UDP-glucuronosyltransferase 1-2 precursor

Identical Sequences to LMP001019 proteins

Reference Database Accession Length Protein Name
GI:32526871 DBBJ BAA13482.1 533 bilirubin UDP-glucuronosyltransferase [Mus musculus]
GI:32526871 DBBJ BAB22243.1 533 unnamed protein product [Mus musculus]
GI:32526871 GenBank EDL40122.1 533 mCG14318, isoform CRA_b [Mus musculus]
GI:32526871 GenBank AAI45970.1 533 Ugt1a2 protein [Mus musculus]
GI:32526871 GenBank AAI38677.1 533 UDP glucuronosyltransferase 1 family, polypeptide A2 [Mus musculus]
GI:32526871 SwissProt P70691.1 533 RecName: Full=UDP-glucuronosyltransferase 1-2; Short=UDPGT 1-2; Short=UGT1*2; Short=UGT1-02; Short=UGT1.2; AltName: Full=Bilirubin-specific UDPGT; AltName: Full=UDP-glucuronosyltransferase 1A2; Short=UGT1A2; Flags: Precursor [Mus musculus]

Related Sequences to LMP001019 proteins

Reference Database Accession Length Protein Name
GI:32526871 GenBank AAA42312.1 531 bilirubin UDP-glucuronosyltransferase (UDPGT) (EC 2.4.1.17) [Rattus norvegicus]
GI:32526871 GenBank AAP48594.1 533 UDP glycosyltransferase 1 family polypeptide A2 [Mus musculus]
GI:32526871 GenBank AAR95631.1 533 UDP glycosyltransferase 1 family polypeptide A2 [Rattus norvegicus]
GI:32526871 GenBank EDL92103.1 533 rCG55639, isoform CRA_a [Rattus norvegicus]
GI:32526871 RefSeq NP_958826.1 533 UDP-glucuronosyltransferase 1-2 precursor [Rattus norvegicus]
GI:32526871 SwissProt P20720.2 533 RecName: Full=UDP-glucuronosyltransferase 1-2; Short=UDPGT 1-2; Short=UGT1*2; Short=UGT1-02; Short=UGT1.2; AltName: Full=B2; AltName: Full=Bilirubin-specific UDPGT; AltName: Full=UDP-glucuronosyltransferase 1A2; Short=UGT1A2; Flags: Precursor [Rattus norvegicus]