Gene/Proteome Database (LMPD)

LMPD ID
LMP001172
Gene ID
5049
Species
Homo sapiens (Human)
Gene Name
platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
Gene Symbol
PAFAH1B2
Synonyms
HEL-S-303
Alternate Names
platelet-activating factor acetylhydrolase IB subunit beta; PAFAH subunit beta; PAF-AH subunit beta; PAF-AH 30 kDa subunit; PAF-AH1b alpha 2 subunit; PAF acetylhydrolase 30 kDa subunit; epididymis secretory protein Li 303; intracellular platelet-activating factor acetylhydrolase alpha 2 subunit; platelet-activating factor acetylhydrolase, isoform Ib, subunit 2 (30kDa)
Chromosome
11
Map Location
11q23
EC Number
3.1.1.47
Summary
Platelet-activating factor acetylhydrolase (PAFAH) inactivates platelet-activating factor (PAF) into acetate and LYSO-PAF. This gene encodes the beta subunit of PAFAH, the other subunits are alpha and gamma. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2014]
Orthologs
View orthologs and multiple alignments for PAFAH1B2

Proteins

platelet-activating factor acetylhydrolase IB subunit beta isoform a
Refseq ID NP_002563
Protein GI 4505585
UniProt ID P68402
mRNA ID NM_002572
Length 229
RefSeq Status VALIDATED
MSQGDSNPAAIPHAAEDIQGDDRWMSQHNRFVLDCKDKEPDVLFVGDSMVQLMQQYEIWRELFSPLHALNFGIGGDTTRHVLWRLKNGELENIKPKVIVVWVGTNNHENTAEEVAGGIEAIVQLINTRQPQAKIIVLGLLPRGEKPNPLRQKNAKVNQLLKVSLPKLANVQLLDTDGGFVHSDGAISCHDMFDFLHLTGGGYAKICKPLHELIMQLLEETPEEKQTTIA
platelet-activating factor acetylhydrolase IB subunit beta isoform b
Refseq ID NP_001171675
Protein GI 296080766
UniProt ID P68402
mRNA ID NM_001184746
Length 202
RefSeq Status VALIDATED
MSQGDSNPAAIPHAAEDIQGDDRWMSQHNRFVLDCKDKEPDVLFVGDSMVQLMQQYEIWRELFSPLHALNFGIGGDTTRHVLWRLKNGELENIKPKVIVVWVGTNNHENTAEEVAGGIEAIVQLINTRQPQAKIIVLGKAAASKYSISEIVRLEQGSVNWSIGTYPDDTPATTRPAILQLFTGKMSRITMKEKSRWTEEILH
platelet-activating factor acetylhydrolase IB subunit beta isoform c
Refseq ID NP_001171676
Protein GI 296080768
UniProt ID P68402
mRNA ID NM_001184747
Length 155
RefSeq Status VALIDATED
MSQGDSNPAAIPHAAEDIQGDDRWMSQHNRFVLDCKDKEPDVLFVGDSMVQLMQQYEIWRELFSPLHALNFGIGGDTTRHVLWRLKNGELENIKPKVIVVWVGTNNHENTAEEVAGGIEAIVQLINTRQPQAKIIVLIIYWQDEQDYHERKVQMD
platelet-activating factor acetylhydrolase IB subunit beta isoform d
Refseq ID NP_001171677
Protein GI 296080770
UniProt ID P68402
mRNA ID NM_001184748
Length 132
RefSeq Status VALIDATED
MSQGDSNPAAIPHAAEDIQGDDRWMSQHNRFVLDCKDKEPDVLFVGDSMVQLMQQYEIWRELFSPLHALNFGIGGDTTRHVLWRLKNGELENIKPKVIVVWVGTNNHENTAEEVAGGIEAIVQLINTRQPQA

Gene Information

Entrez Gene ID
5049
Gene Name
platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
Gene Symbol
PAFAH1B2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 TAS:UniProtKB C cytoplasm
GO:0005829 IEA:Ensembl C cytosol
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0005730 IDA:HPA C nucleolus
GO:0005886 IDA:HPA C plasma membrane
GO:0003847 IEA:UniProtKB-EC F 1-alkyl-2-acetylglycerophosphocholine esterase activity
GO:0007420 IEA:Ensembl P brain development
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0006629 TAS:ProtInc P lipid metabolic process
GO:0016239 IMP:BHF-UCL P positive regulation of macroautophagy
GO:0007283 IEA:Ensembl P spermatogenesis

KEGG Pathway Links

KEGG Pathway ID Description
hsa00565 Ether lipid metabolism
ko00565 Ether lipid metabolism
hsa01100 Metabolic pathways

Domain Information

InterPro Annotations

Accession Description
IPR013831 SGNH_hydro-type_esterase_dom

UniProt Annotations

Entry Information

Gene Name
platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
Protein Entry
PA1B2_HUMAN
UniProt ID
P68402
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=P68402-1; Sequence=Displayed; Name=2; IsoId=P68402-2; Sequence=VSP_042896; Name=3; IsoId=P68402-3; Sequence=VSP_043217; Name=4; IsoId=P68402-4; Sequence=VSP_044680; Note=Ref.2 (ABI58227/ABI58228) sequences are in conflict in position: 151:V->M. {ECO:0000305};
Alternative Products Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=P68402-1; Sequence=Displayed; Name=2; IsoId=P68402-2; Sequence=VSP_042896; Name=3; IsoId=P68402-3; Sequence=VSP_043217; Name=4; IsoId=P68402-4; Sequence=VSP_044680; Note=Ref.2 (ABI58227/ABI58228) sequences are in conflict in position: 151:V->M. ;
Catalytic Activity 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H(2)O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.
Function Inactivates PAF by removing the acetyl group at the sn-2 position. This is a catalytic subunit.
Similarity Belongs to the 'GDSL' lipolytic enzyme family. Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily.
Similarity Belongs to the 'GDSL' lipolytic enzyme family. Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily. {ECO:0000305}.
Subcellular Location Cytoplasm.
Subunit Cytosolic PAF-AH IB is formed of three subunits of 45 kDa (alpha), 30 kDa (beta) and 29 kDa (gamma). The catalytic activity of the enzyme resides in the beta and gamma subunits, whereas the alpha subunit has regulatory activity. Trimer formation is not essential for the catalytic activity.
Tissue Specificity Ubiquitous.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:9144386}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001172 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
4505585 RefSeq NP_002563 229 platelet-activating factor acetylhydrolase IB subunit beta isoform a
296080766 RefSeq NP_001171675 202 platelet-activating factor acetylhydrolase IB subunit beta isoform b
296080768 RefSeq NP_001171676 155 platelet-activating factor acetylhydrolase IB subunit beta isoform c
296080770 RefSeq NP_001171677 132 platelet-activating factor acetylhydrolase IB subunit beta isoform d

Identical Sequences to LMP001172 proteins

Reference Database Accession Length Protein Name
GI:296080770 GenBank ABI58225.1 132 intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 5 [Homo sapiens]
GI:296080768 GenBank ABI58226.1 155 intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 4 [Homo sapiens]
GI:296080768 GenBank ABI58229.1 155 intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 1 [Homo sapiens]
GI:4505585 GenBank AIC49335.1 229 PAFAH1B2, partial [synthetic construct]
GI:4505585 RefSeq XP_008148351.1 229 PREDICTED: platelet-activating factor acetylhydrolase IB subunit beta [Eptesicus fuscus]
GI:4505585 RefSeq XP_008259129.1 229 PREDICTED: platelet-activating factor acetylhydrolase IB subunit beta [Oryctolagus cuniculus]
GI:4505585 RefSeq XP_008688260.1 229 PREDICTED: platelet-activating factor acetylhydrolase IB subunit beta [Ursus maritimus]
GI:4505585 RefSeq XP_008849153.1 229 PREDICTED: platelet-activating factor acetylhydrolase IB subunit beta isoform X1 [Nannospalax galili]
GI:296080770 RefSeq XP_008971767.1 132 PREDICTED: platelet-activating factor acetylhydrolase IB subunit beta isoform X2 [Pan paniscus]
GI:4505585 RefSeq XP_010365705.1 229 PREDICTED: platelet-activating factor acetylhydrolase IB subunit beta [Rhinopithecus roxellana]

Related Sequences to LMP001172 proteins

Reference Database Accession Length Protein Name
GI:296080770 DBBJ BAC56453.1 148 similar to platelet-activating factor acetylhydrolase, beta subunit, partial [Bos taurus]
GI:296080770 GenBank AAC27974.1 229 platelet-activating factor acetylhydrolase alpha 2 subunit [Rattus norvegicus]
GI:296080766 GenBank ABI58227.1 202 intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 3 [Homo sapiens]
GI:296080766 GenBank ABI58228.1 202 intracellular platelet-activating factor acetylhydrolase alpha 2 subunit variant 2 [Homo sapiens]
GI:4505585 GenBank AES03481.1 282 platelet-activating factor acetylhydrolase, isoform Ib, subunit 2, partial [Mustela putorius furo]
GI:4505585 GenBank ELK11884.1 234 Platelet-activating factor acetylhydrolase IB subunit beta [Pteropus alecto]
GI:4505585 RefSeq XP_004427343.1 229 PREDICTED: platelet-activating factor acetylhydrolase IB subunit beta [Ceratotherium simum simum]
GI:4505585 RefSeq XP_004791449.1 242 PREDICTED: platelet-activating factor acetylhydrolase IB subunit beta isoform X1 [Mustela putorius furo]
GI:4505585 RefSeq XP_005579796.1 242 PREDICTED: platelet-activating factor acetylhydrolase IB subunit beta isoform X1 [Macaca fascicularis]
GI:296080770 RefSeq XP_006243019.1 229 PREDICTED: platelet-activating factor acetylhydrolase IB subunit beta isoform X1 [Rattus norvegicus]
GI:296080766 RefSeq XP_006243019.1 229 PREDICTED: platelet-activating factor acetylhydrolase IB subunit beta isoform X1 [Rattus norvegicus]
GI:296080768 RefSeq XP_006243019.1 229 PREDICTED: platelet-activating factor acetylhydrolase IB subunit beta isoform X1 [Rattus norvegicus]
GI:296080766 RefSeq XP_006243020.1 229 PREDICTED: platelet-activating factor acetylhydrolase IB subunit beta isoform X1 [Rattus norvegicus]
GI:296080770 RefSeq XP_006243020.1 229 PREDICTED: platelet-activating factor acetylhydrolase IB subunit beta isoform X1 [Rattus norvegicus]
GI:296080768 RefSeq XP_006243020.1 229 PREDICTED: platelet-activating factor acetylhydrolase IB subunit beta isoform X1 [Rattus norvegicus]
GI:296080770 RefSeq XP_006510147.1 229 PREDICTED: platelet-activating factor acetylhydrolase IB subunit beta isoform X4 [Mus musculus]
GI:296080766 RefSeq XP_006510147.1 229 PREDICTED: platelet-activating factor acetylhydrolase IB subunit beta isoform X4 [Mus musculus]
GI:296080770 RefSeq XP_006510148.1 229 PREDICTED: platelet-activating factor acetylhydrolase IB subunit beta isoform X5 [Mus musculus]
GI:296080768 RefSeq XP_007080480.1 166 PREDICTED: platelet-activating factor acetylhydrolase IB subunit beta isoform X2 [Panthera tigris altaica]
GI:4505585 RefSeq XP_008019178.1 237 PREDICTED: platelet-activating factor acetylhydrolase IB subunit beta isoform X1 [Chlorocebus sabaeus]
GI:296080766 RefSeq XP_009245375.1 229 PREDICTED: platelet-activating factor acetylhydrolase IB subunit beta isoform X1 [Pongo abelii]
GI:296080768 RefSeq XP_009245375.1 229 PREDICTED: platelet-activating factor acetylhydrolase IB subunit beta isoform X1 [Pongo abelii]
GI:296080768 RefSeq XP_009245376.1 186 PREDICTED: platelet-activating factor acetylhydrolase IB subunit beta isoform X2 [Pongo abelii]
GI:296080768 RefSeq XP_010332814.1 151 PREDICTED: platelet-activating factor acetylhydrolase IB subunit beta isoform X3 [Saimiri boliviensis boliviensis]