Gene/Proteome Database (LMPD)

LMPD ID
LMP001175
Gene ID
350
Species
Homo sapiens (Human)
Gene Name
apolipoprotein H (beta-2-glycoprotein I)
Gene Symbol
APOH
Synonyms
B2G1; B2GP1; BG
Alternate Names
beta-2-glycoprotein 1; B2GPI; apo-H; beta(2)GPI; APC inhibitor; anticardiolipin cofactor; activated protein C-binding protein
Chromosome
17
Map Location
17q24.2
Summary
Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for APOH

Proteins

beta-2-glycoprotein 1 precursor
Refseq ID NP_000033
Protein GI 153266841
UniProt ID P02749
mRNA ID NM_000042
Length 345
RefSeq Status REVIEWED
MISPVLILFSSFLCHVAIAGRTCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTKLPECREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSAMPSCKASCKVPVKKATVVYQGERVKIQEKFKNGMLHGDKVSFFCKNKEKKCSYTEDAQCIDGTIEVPKCFKEHSSLAFWKTDASDVKPC
sig_peptide: 1..19 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2062 peptide sequence: MISPVLILFSSFLCHVAIA mat_peptide: 20..345 product: beta-2-glycoprotein 1 calculated_mol_wt: 36255 peptide sequence: GRTCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTKLPECREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSAMPSCKASCKVPVKKATVVYQGERVKIQEKFKNGMLHGDKVSFFCKNKEKKCSYTEDAQCIDGTIEVPKCFKEHSSLAFWKTDASDVKPC

Gene Information

Entrez Gene ID
350
Gene Name
apolipoprotein H (beta-2-glycoprotein I)
Gene Symbol
APOH
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009986 IDA:BHF-UCL C cell surface
GO:0042627 IDA:BHF-UCL C chylomicron
GO:0005615 IDA:BHF-UCL C extracellular space
GO:0070062 IDA:UniProtKB C extracellular vesicular exosome
GO:0034364 IDA:BHF-UCL C high-density lipoprotein particle
GO:0034361 IDA:BHF-UCL C very-low-density lipoprotein particle
GO:0001948 IPI:BHF-UCL F glycoprotein binding
GO:0008201 IEA:UniProtKB-KW F heparin binding
GO:0042802 IPI:IntAct F identical protein binding
GO:0008289 IDA:BHF-UCL F lipid binding
GO:0060230 IDA:BHF-UCL F lipoprotein lipase activator activity
GO:0005543 IDA:BHF-UCL F phospholipid binding
GO:0007597 IDA:BHF-UCL P blood coagulation, intrinsic pathway
GO:0016525 IDA:BHF-UCL P negative regulation of angiogenesis
GO:0030195 IDA:BHF-UCL P negative regulation of blood coagulation
GO:0010596 IDA:BHF-UCL P negative regulation of endothelial cell migration
GO:0001937 IDA:BHF-UCL P negative regulation of endothelial cell proliferation
GO:0051918 IDA:BHF-UCL P negative regulation of fibrinolysis
GO:0033033 IDA:BHF-UCL P negative regulation of myeloid cell apoptotic process
GO:0034392 IDA:BHF-UCL P negative regulation of smooth muscle cell apoptotic process
GO:0031639 IDA:BHF-UCL P plasminogen activation
GO:0030194 TAS:BHF-UCL P positive regulation of blood coagulation
GO:0051006 IDA:BHF-UCL P positive regulation of lipoprotein lipase activity
GO:0051917 IDA:BHF-UCL P regulation of fibrinolysis
GO:0006641 IDA:BHF-UCL P triglyceride metabolic process
GO:0034197 ISS:BHF-UCL P triglyceride transport

Domain Information

InterPro Annotations

Accession Description
IPR015104 Beta-2-glycoprotein-1 fifth domain
IPR000436 Sushi/SCR/CCP domain

UniProt Annotations

Entry Information

Gene Name
apolipoprotein H (beta-2-glycoprotein I)
Protein Entry
APOH_HUMAN
UniProt ID
P02749
Species
Human

Comments

Comment Type Description
Function Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
Interaction Self; NbExp=2; IntAct=EBI-2114682, EBI-2114682; P08519:LPA; NbExp=4; IntAct=EBI-2114682, EBI-9232288; P00747:PLG; NbExp=2; IntAct=EBI-2114682, EBI-999394;
Ptm N- and O-glycosylated. PubMed:6587378 also reports glycosylation on 'Asn-188' for their allele. {ECO
Similarity Contains 4 Sushi (CCP/SCR) domains.
Subcellular Location Secreted.
Tissue Specificity Expressed by the liver and secreted in plasma.
Web Resource Name=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=APOH";
Web Resource Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/apoh/";

Identical and Related Proteins

Unique RefSeq proteins for LMP001175 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
153266841 RefSeq NP_000033 345 beta-2-glycoprotein 1 precursor

Identical Sequences to LMP001175 proteins

Reference Database Accession Length Protein Name
GI:153266841 GenBank ADS30581.1 345 Sequence 1113 from patent US 7781168
GI:153266841 GenBank ADS30583.1 345 Sequence 1115 from patent US 7781168
GI:153266841 GenBank ADS59164.1 345 Sequence 315 from patent US 7807392
GI:153266841 GenBank AEN35210.1 345 Sequence 1138 from patent US 7998689
GI:153266841 GenBank AEN35211.1 345 Sequence 1139 from patent US 7998689
GI:153266841 GenBank AIC48281.1 345 APOH, partial [synthetic construct]

Related Sequences to LMP001175 proteins

Reference Database Accession Length Protein Name
GI:153266841 EMBL CAA41113.1 345 Beta-2-glycoprotein I apolipoprotein H [Homo sapiens]
GI:153266841 GenBank AEH96847.1 690 Sequence 13 from patent US 7947267
GI:153266841 GenBank AER70417.1 690 Sequence 13 from patent US 8043609
GI:153266841 GenBank AEW40269.1 345 Sequence 139 from patent US 8071291
GI:153266841 GenBank AFO05695.1 345 Sequence 333 from patent US 8216786
GI:153266841 GenBank AHE01112.1 345 Sequence 56028 from patent US 8586006