Gene/Proteome Database (LMPD)

LMPD ID
LMP001418
Gene ID
337
Species
Homo sapiens (Human)
Gene Name
apolipoprotein A-IV
Gene Symbol
APOA4
Synonyms
-
Chromosome
11
Map Location
11q23
Summary
Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for APOA4

Proteins

apolipoprotein A-IV precursor
Refseq ID NP_000473
Protein GI 71773110
UniProt ID NONE
mRNA ID NM_000482
Length 396
RefSeq Status REVIEWED
MFLKAVVLTLALVAVAGARAEVSADQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQEQVQMLAPLES
sig_peptide: 1..20 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2015 peptide sequence: MFLKAVVLTLALVAVAGARA mat_peptide: 21..396 product: apolipoprotein A-IV calculated_mol_wt: 43376 peptide sequence: EVSADQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQEQVQMLAPLES

Gene Information

Entrez Gene ID
337
Gene Name
apolipoprotein A-IV
Gene Symbol
APOA4
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0072562 IDA:UniProt C blood microparticle
GO:0042627 IDA:BHF-UCL C chylomicron
GO:0005829 TAS:Reactome C cytosol
GO:0005769 TAS:Reactome C early endosome
GO:0005788 TAS:Reactome C endoplasmic reticulum lumen
GO:0005576 NAS:UniProtKB C extracellular region
GO:0005615 IDA:BHF-UCL C extracellular space
GO:0070062 IDA:UniProtKB C extracellular vesicular exosome
GO:0034364 IDA:BHF-UCL C high-density lipoprotein particle
GO:0034361 IDA:BHF-UCL C very-low-density lipoprotein particle
GO:0016209 IDA:HGNC F antioxidant activity
GO:0017127 IDA:BHF-UCL F cholesterol transporter activity
GO:0005507 IDA:HGNC F copper ion binding
GO:0008289 IMP:BHF-UCL F lipid binding
GO:0005319 TAS:ProtInc F lipid transporter activity
GO:0031210 IDA:BHF-UCL F phosphatidylcholine binding
GO:0060228 IDA:BHF-UCL F phosphatidylcholine-sterol O-acyltransferase activator activity
GO:0042803 IDA:BHF-UCL F protein homodimerization activity
GO:0033344 IDA:BHF-UCL P cholesterol efflux
GO:0042632 IDA:BHF-UCL P cholesterol homeostasis
GO:0008203 IDA:BHF-UCL P cholesterol metabolic process
GO:0034378 TAS:BHF-UCL P chylomicron assembly
GO:0034371 IC:BHF-UCL P chylomicron remodeling
GO:0034375 IC:BHF-UCL P high-density lipoprotein particle remodeling
GO:0042744 IDA:HGNC P hydrogen peroxide catabolic process
GO:0002227 IDA:BHF-UCL P innate immune response in mucosa
GO:0007159 IDA:BHF-UCL P leukocyte cell-cell adhesion
GO:0055088 IDA:BHF-UCL P lipid homeostasis
GO:0006869 IDA:BHF-UCL P lipid transport
GO:0042157 TAS:Reactome P lipoprotein metabolic process
GO:0044240 IDA:BHF-UCL P multicellular organismal lipid catabolic process
GO:0034445 IDA:BHF-UCL P negative regulation of plasma lipoprotein particle oxidation
GO:0046470 IDA:BHF-UCL P phosphatidylcholine metabolic process
GO:0033700 IDA:BHF-UCL P phospholipid efflux
GO:0007603 TAS:Reactome P phototransduction, visible light
GO:0010873 IDA:BHF-UCL P positive regulation of cholesterol esterification
GO:0045723 IDA:BHF-UCL P positive regulation of fatty acid biosynthetic process
GO:0051006 IDA:BHF-UCL P positive regulation of lipoprotein lipase activity
GO:0010898 IDA:BHF-UCL P positive regulation of triglyceride catabolic process
GO:0065005 IMP:BHF-UCL P protein-lipid complex assembly
GO:0032374 IDA:BHF-UCL P regulation of cholesterol transport
GO:0030300 IEA:Ensembl P regulation of intestinal cholesterol absorption
GO:0019430 IDA:HGNC P removal of superoxide radicals
GO:0006982 IDA:HGNC P response to lipid hydroperoxide
GO:0035634 IEA:Ensembl P response to stilbenoid
GO:0001523 TAS:Reactome P retinoid metabolic process
GO:0043691 IDA:BHF-UCL P reverse cholesterol transport
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0034372 IDA:BHF-UCL P very-low-density lipoprotein particle remodeling

KEGG Pathway Links

KEGG Pathway ID Description
hsa04975 Fat digestion and absorption
ko04975 Fat digestion and absorption
hsa04977 Vitamin digestion and absorption
ko04977 Vitamin digestion and absorption

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_75925 Amyloids
REACT_6841 Chylomicron-mediated lipid transport
REACT_116125 Disease
REACT_160102 Diseases associated with visual transduction
REACT_602 Lipid digestion, mobilization, and transport
REACT_6823 Lipoprotein metabolism
REACT_111217 Metabolism
REACT_22258 Metabolism of lipids and lipoproteins
REACT_24968 Retinoid metabolism and transport
REACT_111102 Signal Transduction
REACT_160125 Visual phototransduction

Domain Information

InterPro Annotations

Accession Description
IPR000074 Apolipoprotein A/E

UniProt Annotations

Entry Information

Gene Name
apolipoprotein A-IV
Protein Entry
NONE_CAEEL
UniProt ID
NONE
Species
Human

Comments

Comment Type Description
Domain Nine of the thirteen 22-amino acid tandem repeats (each 22-mer is actually a tandem array of two, A and B, related 11- mers) occurring in this sequence are predicted to be highly alpha- helical, and many of these helices are amphipathic. They may therefore serve as lipid-binding domains with lecithin:cholesterol acyltransferase (LCAT) activating abilities.
Function May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.
Polymorphism Eight alleles have been characterized (APOA-IV*0 to APOA-IV*7). APOA-IV*1 is the major allele (90%), APOA-IV*2 is also common (8%), the others are rare alleles. The sequence shown represents allele APOA-IV*1.
Ptm Phosphorylation sites are present in the extracellular medium.
Similarity Belongs to the apolipoprotein A1/A4/E family. {ECO:0000305}.
Subcellular Location Secreted.
Subunit Homodimer. {ECO:0000269|PubMed:22579246}.
Tissue Specificity Synthesized primarily in the intestine and secreted in plasma.
Web Resource Name=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=APOA4";

Identical and Related Proteins

Unique RefSeq proteins for LMP001418 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
71773110 RefSeq NP_000473 396 apolipoprotein A-IV precursor

Identical Sequences to LMP001418 proteins

Reference Database Accession Length Protein Name
GI:71773110 GenBank AFO05692.1 396 Sequence 330 from patent US 8216786
GI:71773110 GenBank AHE02191.1 396 Sequence 60545 from patent US 8586006

Related Sequences to LMP001418 proteins

Reference Database Accession Length Protein Name
GI:71773110 GenBank AAQ91809.1 396 apolipoprotein A-IV [Homo sapiens]
GI:71773110 GenBank AAS68228.1 396 apolipoprotein A-IV [Homo sapiens]
GI:71773110 GenBank AAI13595.1 396 Apolipoprotein A-IV [Homo sapiens]
GI:71773110 GenBank AAI13597.1 396 Apolipoprotein A-IV [Homo sapiens]
GI:71773110 GenBank ACP57502.1 396 Sequence 1631 from patent US 7482117
GI:71773110 SwissProt P06727.3 396 RecName: Full=Apolipoprotein A-IV; Short=Apo-AIV; Short=ApoA-IV; AltName: Full=Apolipoprotein A4; Flags: Precursor [Homo sapiens]