Gene/Proteome Database (LMPD)

LMPD ID
LMP001618
Gene ID
10449
Species
Homo sapiens (Human)
Gene Name
acetyl-CoA acyltransferase 2
Gene Symbol
ACAA2
Synonyms
DSAEC
Chromosome
18
Map Location
18q21.1
Summary
The encoded protein catalyzes the last step of the mitochondrial fatty acid beta-oxidation spiral. Unlike most mitochondrial matrix proteins, it contains a non-cleavable amino-terminal targeting signal. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for ACAA2

Proteins

3-ketoacyl-CoA thiolase, mitochondrial
Refseq ID NP_006102
Protein GI 167614485
UniProt ID P42765
mRNA ID NM_006111
Length 397
RefSeq Status REVIEWED
MALLRGVFVVAAKRTPFGAYGGLLKDFTATDLSEFAAKAALSAGKVSPETVDSVIMGNVLQSSSDAIYLARHVGLRVGIPKETPALTINRLCGSGFQSIVNGCQEICVKEAEVVLCGGTESMSQAPYCVRNVRFGTKLGSDIKLEDSLWVSLTDQHVQLPMAMTAENLAVKHKISREECDKYALQSQQRWKAANDAGYFNDEMAPIEVKTKKGKQTMQVDEHARPQTTLEQLQKLPPVFKKDGTVTAGNASGVADGAGAVIIASEDAVKKHNFTPLARIVGYFVSGCDPSIMGIGPVPAISGALKKAGLSLKDMDLVEVNEAFAPQYLAVERSLDLDISKTNVNGGAIALGHPLGGSGSRITAHLVHELRRRGGKYAVGSACIGGGQGIAVIIQSTA

Gene Information

Entrez Gene ID
10449
Gene Name
acetyl-CoA acyltransferase 2
Gene Symbol
ACAA2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016747 IEA:InterPro F transferase activity, transferring acyl groups other than amino-acyl groups

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6061 bile acid biosynthesis, neutral pathway
FAO-PWY fatty acid beta-oxidation I

Domain Information

InterPro Annotations

Accession Description
IPR002155 Thiolase
IPR020617 Thiolase, C-terminal
IPR020616 Thiolase, N-terminal
IPR020610 Thiolase, active site
IPR020615 Thiolase, acyl-enzyme intermediate active site
IPR020613 Thiolase, conserved site
IPR016039 Thiolase-like
IPR016038 Thiolase-like, subgroup

UniProt Annotations

Entry Information

Gene Name
acetyl-CoA acyltransferase 2
Protein Entry
THIM_HUMAN
UniProt ID
P42765
Species
Human

Identical and Related Proteins

Unique RefSeq proteins for LMP001618 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
167614485 RefSeq NP_006102 397 3-ketoacyl-CoA thiolase, mitochondrial

Identical Sequences to LMP001618 proteins

Reference Database Accession Length Protein Name
GI:167614485 DBBJ BAI47333.1 397 acetyl-Coenzyme A acyltransferase 2, partial [synthetic construct]
GI:167614485 GenBank ADA19144.1 397 Sequence 968 from patent US 7608413
GI:167614485 GenBank ADA19147.1 397 Sequence 971 from patent US 7608413
GI:167614485 GenBank AEN35040.1 397 Sequence 968 from patent US 7998689
GI:167614485 GenBank AEN35043.1 397 Sequence 971 from patent US 7998689
GI:167614485 GenBank AIC50630.1 397 ACAA2, partial [synthetic construct]

Related Sequences to LMP001618 proteins

Reference Database Accession Length Protein Name
GI:167614485 DBBJ BAG51410.1 397 unnamed protein product [Homo sapiens]
GI:167614485 GenBank ACM82134.1 413 Sequence 7632 from patent US 6812339
GI:167614485 PDB 4C2K 417 Chain A, Crystal Structure Of Human Mitochondrial 3-ketoacyl-coa Thiolase
GI:167614485 PDB 4C2K 417 Chain B, Crystal Structure Of Human Mitochondrial 3-ketoacyl-coa Thiolase
GI:167614485 PDB 4C2K 417 Chain C, Crystal Structure Of Human Mitochondrial 3-ketoacyl-coa Thiolase
GI:167614485 PDB 4C2K 417 Chain D, Crystal Structure Of Human Mitochondrial 3-ketoacyl-coa Thiolase