Gene/Proteome Database (LMPD)

LMPD ID
LMP001699
Gene ID
55331
Species
Homo sapiens (Human)
Gene Name
alkaline ceramidase 3
Gene Symbol
ACER3
Synonyms
APHC; PHCA
Chromosome
11
Map Location
11q13.5
EC Number
3.5.1.-

Proteins

alkaline ceramidase 3 isoform a
Refseq ID NP_060837
Protein GI 170932467
UniProt ID Q9NUN7
mRNA ID NM_018367
Length 267
RefSeq Status VALIDATED
MAPAADREGYWGPTTSTLDWCEENYSVTWYIAEFWNTVSNLIMIIPPMFGAVQSVRDGLEKRYIASYLALTVVGMGSWCFHMTLKYEMQLLDELPMIYSCCIFVYCMFECFKIKNSVNYHLLFTLVLFSLIVTTVYLKVKEPIFHQVMYGMLVFTLVLRSIYIVTWVYPWLRGLGYTSLGIFLLGFLFWNIDNIFCESLRNFRKKVPPIIGITTQFHAWWHILTGLGSYLHILFSLYTRTLYLRYRPKVKFLFGIWPVILFEPLRKH
alkaline ceramidase 3 isoform b
Refseq ID NP_001287882
Protein GI 665821252
UniProt ID B7Z2Q2
mRNA ID NM_001300953
Length 230
RefSeq Status VALIDATED
MAPAADREGYWGPTTSTLDWCEENYSVTWYIAEFLVGMGSWCFHMTLKYEMQLLDELPMIYSCCIFVYCMFECFKIKNSVNYHLLFTLVLFSLIVTTVYLKVKEPIFHQVMYGMLVFTLVLRSIYIVTWVYPWLRGLGYTSLGIFLLGFLFWNIDNIFCESLRNFRKKVPPIIGITTQFHAWWHILTGLGSYLHILFSLYTRTLYLRYRPKVKFLFGIWPVILFEPLRKH
alkaline ceramidase 3 isoform c
Refseq ID NP_001287884
Protein GI 665821215
UniProt ID B7Z2V2
mRNA ID NM_001300955
Length 172
RefSeq Status VALIDATED
MIYSCCIFVYCMFECFKIKNSVNYHLLFTLVLFSLIVTTVYLKVKEPIFHQVMYGMLVFTLVLRSIYIVTWVYPWLRGLGYTSLGIFLLGFLFWNIDNIFCESLRNFRKKVPPIIGITTQFHAWWHILTGLGSYLHILFSLYTRTLYLRYRPKVKFLFGIWPVILFEPLRKH
alkaline ceramidase 3 isoform c
Refseq ID NP_001287883
Protein GI 665821239
UniProt ID B7Z2V2
mRNA ID NM_001300954
Length 172
RefSeq Status VALIDATED
Protein sequence is identical to GI:665821215 (mRNA isoform)

Gene Information

Entrez Gene ID
55331
Gene Name
alkaline ceramidase 3
Gene Symbol
ACER3
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0030176 IDA:UniProtKB C integral component of endoplasmic reticulum membrane
GO:0030173 IDA:UniProtKB C integral component of Golgi membrane
GO:0070774 IDA:UniProtKB F phytoceramidase activity
GO:0006672 IEA:InterPro P ceramide metabolic process
GO:0071602 IDA:UniProtKB P phytosphingosine biosynthetic process
GO:0008284 IMP:UniProtKB P positive regulation of cell proliferation
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0030148 TAS:Reactome P sphingolipid biosynthetic process
GO:0006665 TAS:Reactome P sphingolipid metabolic process
GO:0046512 IDA:UniProtKB P sphingosine biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00600 Sphingolipid metabolism
ko00600 Sphingolipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_115810 Sphingolipid de novo biosynthesis
REACT_19323 Sphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR008901 Ceramidase

UniProt Annotations

Entry Information

Gene Name
alkaline ceramidase 3
Protein Entry
ACER3_HUMAN
UniProt ID
Q9NUN7
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NUN7-1; Sequence=Displayed; Name=2; IsoId=Q9NUN7-2; Sequence=VSP_039162, VSP_039163; Note=No experimental confirmation available.;
Enzyme Regulation Activated by Ca(2+) and inhibited by Zn(2+).
Function Hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Does not have reverse activity.
Similarity Belongs to the alkaline ceramidase family.
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Tissue Specificity Ubiquitously expressed. Highest expression in placenta.

Identical and Related Proteins

Unique RefSeq proteins for LMP001699 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
170932467 RefSeq NP_060837 267 alkaline ceramidase 3 isoform a
665821252 RefSeq NP_001287882 230 alkaline ceramidase 3 isoform b
665821215 RefSeq NP_001287884 172 alkaline ceramidase 3 isoform c

Identical Sequences to LMP001699 proteins

Reference Database Accession Length Protein Name
GI:665821252 DBBJ BAH11938.1 230 unnamed protein product [Homo sapiens]
GI:665821215 DBBJ BAH11988.1 172 unnamed protein product [Homo sapiens]
GI:665821215 DBBJ BAH14491.1 172 unnamed protein product [Homo sapiens]
GI:665821215 RefSeq NP_001287883.1 172 alkaline ceramidase 3 isoform c [Homo sapiens]
GI:665821215 RefSeq XP_009422073.1 172 PREDICTED: alkaline ceramidase 3 isoform X2 [Pan troglodytes]
GI:170932467 SwissProt Q9NUN7.3 267 RecName: Full=Alkaline ceramidase 3; Short=AlkCDase 3; Short=Alkaline CDase 3; AltName: Full=Alkaline dihydroceramidase SB89; AltName: Full=Alkaline phytoceramidase; Short=aPHC [Homo sapiens]

Related Sequences to LMP001699 proteins

Reference Database Accession Length Protein Name
GI:170932467 DBBJ BAG37496.1 267 unnamed protein product [Homo sapiens]
GI:665821215 GenBank AAH73853.1 267 Alkaline ceramidase 3 [Homo sapiens]
GI:170932467 GenBank EAW75010.1 267 phytoceramidase, alkaline, isoform CRA_b [Homo sapiens]
GI:170932467 GenBank ADQ31994.1 267 phytoceramidase, alkaline, partial [synthetic construct]
GI:665821215 GenBank ADQ31994.1 267 phytoceramidase, alkaline, partial [synthetic construct]
GI:170932467 GenBank AIC56677.1 267 ACER3, partial [synthetic construct]
GI:665821215 GenBank AIC56677.1 267 ACER3, partial [synthetic construct]
GI:170932467 RefSeq XP_001175032.1 267 PREDICTED: alkaline ceramidase 3 isoform X1 [Pan troglodytes]
GI:665821215 RefSeq XP_001175032.1 267 PREDICTED: alkaline ceramidase 3 isoform X1 [Pan troglodytes]
GI:665821215 RefSeq NP_060837.3 267 alkaline ceramidase 3 isoform a [Homo sapiens]
GI:170932467 RefSeq XP_003808199.1 267 PREDICTED: alkaline ceramidase 3 [Pan paniscus]
GI:665821252 RefSeq XP_004016392.1 230 PREDICTED: alkaline ceramidase 3 [Ovis aries]
GI:665821252 RefSeq XP_004090661.1 230 PREDICTED: alkaline ceramidase 3 isoform 2 [Nomascus leucogenys]
GI:665821252 RefSeq XP_004683285.1 230 PREDICTED: alkaline ceramidase 3 isoform X2 [Condylura cristata]
GI:665821252 RefSeq XP_004882021.1 230 PREDICTED: alkaline ceramidase 3 isoform X3 [Heterocephalus glaber]
GI:665821252 RefSeq XP_005954152.1 230 PREDICTED: alkaline ceramidase 3 isoform X2 [Pantholops hodgsonii]
GI:665821252 RefSeq XP_007939104.1 230 PREDICTED: alkaline ceramidase 3 isoform X2 [Orycteropus afer afer]
GI:665821215 SwissProt Q9NUN7.3 267 RecName: Full=Alkaline ceramidase 3; Short=AlkCDase 3; Short=Alkaline CDase 3; AltName: Full=Alkaline dihydroceramidase SB89; AltName: Full=Alkaline phytoceramidase; Short=aPHC [Homo sapiens]