Gene/Proteome Database (LMPD)

LMPD ID
LMP001700
Gene ID
18171
Species
Mus musculus (Mouse)
Gene Name
nuclear receptor subfamily 1, group I, member 2
Gene Symbol
Nr1i2
Synonyms
PXR; PXR.1; PXR.2; PXR1; SXR; mPXR
Alternate Names
nuclear receptor subfamily 1 group I member 2; Pregnane X receptor; orphan nuclear receptor PXR
Chromosome
16
Map Location
16 B3|16

Proteins

nuclear receptor subfamily 1 group I member 2 isoform 1
Refseq ID NP_035066
Protein GI 33468913
UniProt ID O54915
mRNA ID NM_010936
Length 431
RefSeq Status VALIDATED
MRPEESWSRVGLVQCEEADSALEEPINVEEEDGGLQICRVCGDKANGYHFNVMTCEGCKGFFRRAMKRNVRLRCPFRKGTCEITRKTRRQCQACRLRKCLESGMKKEMIMSDAAVEQRRALIKRKKREKIEAPPPGGQGLTEEQQALIQELMDAQMQTFDTTFSHFKDFRLPAVFHSGCELPEFLQASLLEDPATWSQIMKDRVPMKISLQLRGEDGSIWNYQPPSKSDGKEIIPLLPHLADVSTYMFKGVINFAKVISYFRDLPIEDQISLLKGATFEMCILRFNTMFDTETGTWECGRLAYCFEDPNGGFQKLLLDPLMKFHCMLKKLQLHKEEYVLMQAISLFSPDRPGVVQRSVVDQLQERFALTLKAYIECSRPYPAHRFLFLKIMAVLTELRSINAQQTQQLLRIQDSHPFATPLMQELFSSTDG
nuclear receptor subfamily 1 group I member 2 isoform 2
Refseq ID NP_001091874
Protein GI 148536879
UniProt ID O54915
mRNA ID NM_001098404
Length 390
RefSeq Status VALIDATED
MRPEESWSRVGLVQCEEADSALEEPINVEEEDGGLQICRVCGDKANGYHFNVMTCEGCKGFFRRAMKRNVRLRCPFRKGTCEITRKTRRQCQACRLRKCLESGMKKEMIMSDAAVEQRRALIKRKKREKIEAPPPGGQGLTEEQQALIQELMDAQMQTFDTTFSHFKDFRLRGEDGSIWNYQPPSKSDGKEIIPLLPHLADVSTYMFKGVINFAKVISYFRDLPIEDQISLLKGATFEMCILRFNTMFDTETGTWECGRLAYCFEDPNGGFQKLLLDPLMKFHCMLKKLQLHKEEYVLMQAISLFSPDRPGVVQRSVVDQLQERFALTLKAYIECSRPYPAHRFLFLKIMAVLTELRSINAQQTQQLLRIQDSHPFATPLMQELFSSTDG

Gene Information

Entrez Gene ID
18171
Gene Name
nuclear receptor subfamily 1, group I, member 2
Gene Symbol
Nr1i2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0000977 IEA:Ensembl F RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228 IEA:Ensembl F RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0008144 ISS:UniProtKB F drug binding
GO:0004879 ISS:UniProtKB F ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0046618 ISS:UniProtKB P drug export
GO:0042738 ISS:UniProtKB P exogenous drug catabolic process
GO:0045892 ISO:MGI P negative regulation of transcription, DNA-templated
GO:0010628 IMP:MGI P positive regulation of gene expression
GO:0045893 ISS:UniProtKB P positive regulation of transcription, DNA-templated
GO:0006805 ISS:UniProtKB P xenobiotic metabolic process
GO:0042908 ISS:UniProtKB P xenobiotic transport

REACTOME Pathway Links

REACTOME Pathway ID Description
5893343 Generic Transcription Pathway
5893658 Nuclear Receptor transcription pathway

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001723 Steroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
nuclear receptor subfamily 1, group I, member 2
Protein Entry
NR1I2_MOUSE
UniProt ID
O54915
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=PXR.1; IsoId=O54915-1; Sequence=Displayed; Name=2; Synonyms=PXR.2; IsoId=O54915-2; Sequence=VSP_003670;
Function Nuclear receptor that binds and is activated by a variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, endogenous compounds and drugs. Response to specific ligands is species-specific, due to differences in the ligand- binding domain. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes (By similarity). Activated by naturally occurring steroids such as pregnenolone and progesterone, the cholesterol metabolite 5-beta-cholestane-3- alpha,7-alpha,12-alpha-triol, synthetic glucocorticoids and antiglucocorticoids and 16-alpha-carbonitrile (PCN). {ECO:0000250, ECO:0000269|PubMed:12569201, ECO:0000269|PubMed:19297428}.
Similarity Belongs to the nuclear hormone receptor family. NR1 subfamily. {ECO:0000305}.
Similarity Contains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}.
Subunit Heterodimer with RXRA. Interacts with NCOA1 (By similarity). {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001700 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
33468913 RefSeq NP_035066 431 nuclear receptor subfamily 1 group I member 2 isoform 1
148536879 RefSeq NP_001091874 390 nuclear receptor subfamily 1 group I member 2 isoform 2

Identical Sequences to LMP001700 proteins

Reference Database Accession Length Protein Name
GI:33468913 DBBJ BAB31316.1 431 unnamed protein product [Mus musculus]
GI:33468913 GenBank AAI20797.1 431 Nuclear receptor subfamily 1, group I, member 2 [Mus musculus]
GI:33468913 GenBank EDK97971.1 431 nuclear receptor subfamily 1, group I, member 2 [Mus musculus]
GI:33468913 GenBank AAI37781.1 431 Nuclear receptor subfamily 1, group I, member 2 [Mus musculus]
GI:33468913 RefSeq XP_006521909.1 431 PREDICTED: nuclear receptor subfamily 1 group I member 2 isoform X1 [Mus musculus]
GI:33468913 RefSeq XP_006521911.1 431 PREDICTED: nuclear receptor subfamily 1 group I member 2 isoform X3 [Mus musculus]

Related Sequences to LMP001700 proteins

Reference Database Accession Length Protein Name
GI:148536879 GenBank AAC39964.1 431 pregnane X receptor [Mus musculus]
GI:33468913 GenBank AAD47214.1 431 pregnane X receptor [Rattus norvegicus]
GI:148536879 GenBank EDK97971.1 431 nuclear receptor subfamily 1, group I, member 2 [Mus musculus]
GI:33468913 GenBank EDM11231.1 431 nuclear receptor subfamily 1, group I, member 2 [Rattus norvegicus]
GI:33468913 RefSeq NP_443212.1 431 nuclear receptor subfamily 1 group I member 2 [Rattus norvegicus]
GI:148536879 RefSeq NP_035066.1 431 nuclear receptor subfamily 1 group I member 2 isoform 1 [Mus musculus]
GI:148536879 RefSeq XP_006521909.1 431 PREDICTED: nuclear receptor subfamily 1 group I member 2 isoform X1 [Mus musculus]
GI:148536879 RefSeq XP_006521911.1 431 PREDICTED: nuclear receptor subfamily 1 group I member 2 isoform X3 [Mus musculus]
GI:33468913 RefSeq XP_006975795.1 432 PREDICTED: nuclear receptor subfamily 1 group I member 2 isoform X1 [Peromyscus maniculatus bairdii]
GI:33468913 RefSeq XP_006975796.1 432 PREDICTED: nuclear receptor subfamily 1 group I member 2 isoform X2 [Peromyscus maniculatus bairdii]
GI:148536879 SwissProt O54915.1 431 RecName: Full=Nuclear receptor subfamily 1 group I member 2; AltName: Full=Orphan nuclear receptor PXR; AltName: Full=Pregnane X receptor [Mus musculus]
GI:33468913 SwissProt Q9R1A7.1 431 RecName: Full=Nuclear receptor subfamily 1 group I member 2; AltName: Full=Orphan nuclear receptor PXR; AltName: Full=Pregnane X receptor [Rattus norvegicus]