Gene/Proteome Database (LMPD)

LMPD ID
LMP001853
Gene ID
1743
Species
Homo sapiens (Human)
Gene Name
dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
Gene Symbol
DLST
Synonyms
DLTS
Chromosome
14
Map Location
14q24.3
EC Number
2.3.1.61
Summary
This gene encodes a mitochondrial protein that belongs to the 2-oxoacid dehydrogenase family. This protein is one of the three components (the E2 component) of the 2-oxoglutarate dehydrogenase complex that catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]
Orthologs
View orthologs and multiple alignments for DLST

Proteins

dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform 1 precursor
Refseq ID NP_001924
Protein GI 19923748
UniProt ID P36957
mRNA ID NM_001933
Length 453
RefSeq Status REVIEWED
MLSRSRCVSRAFSRSLSAFQKGNCPLGRRSLPGVSLCQGPGYPNSRKVVINNSVFSVRFFRTTAVCKDDLVTVKTPAFAESVTEGDVRWEKAVGDTVAEDEVVCEIETDKTSVQVPSPANGVIEALLVPDGGKVEGGTPLFTLRKTGAAPAKAKPAEAPAAAAPKAEPTAAAVPPPAAPIPTQMPPVPSPSQPPSGKPVSAVKPTVAPPLAEPGAGKGLRSEHREKMNRMRQRIAQRLKEAQNTCAMLTTFNEIDMSNIQEMRARHKEAFLKKHNLKLGFMSAFVKASAFALQEQPVVNAVIDDTTKEVVYRDYIDISVAVATPRGLVVPVIRNVEAMNFADIERTITELGEKARKNELAIEDMDGGTFTISNGGVFGSLFGTPIINPPQSAILGMHGIFDRPVAIGGKVEVRPMMYVALTYDHRLIDGREAVTFLRKIKAAVEDPRVLLLDL
transit_peptide: 1..67 calculated_mol_wt: 7384 peptide sequence: MLSRSRCVSRAFSRSLSAFQKGNCPLGRRSLPGVSLCQGPGYPNSRKVVINNSVFSVRFFRTTAVCK mat_peptide: 68..166 product: dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform 2 calculated_mol_wt: 10511 peptide sequence: DDLVTVKTPAFAESVTEGDVRWEKAVGDTVAEDEVVCEIETDKTSVQVPSPANGVIEALLVPDGGKVEGGTPLFTLRKTGGKEVLLVVKVSSVPSWDWD transit_peptide: 1..67 calculated_mol_wt: 7384 peptide sequence: MLSRSRCVSRAFSRSLSAFQKGNCPLGRRSLPGVSLCQGPGYPNSRKVVINNSVFSVRFFRTTAVCK mat_peptide: 68..453 product: dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform 1 calculated_mol_wt: 41390 peptide sequence: DDLVTVKTPAFAESVTEGDVRWEKAVGDTVAEDEVVCEIETDKTSVQVPSPANGVIEALLVPDGGKVEGGTPLFTLRKTGAAPAKAKPAEAPAAAAPKAEPTAAAVPPPAAPIPTQMPPVPSPSQPPSGKPVSAVKPTVAPPLAEPGAGKGLRSEHREKMNRMRQRIAQRLKEAQNTCAMLTTFNEIDMSNIQEMRARHKEAFLKKHNLKLGFMSAFVKASAFALQEQPVVNAVIDDTTKEVVYRDYIDISVAVATPRGLVVPVIRNVEAMNFADIERTITELGEKARKNELAIEDMDGGTFTISNGGVFGSLFGTPIINPPQSAILGMHGIFDRPVAIGGKVEVRPMMYVALTYDHRLIDGREAVTFLRKIKAAVEDPRVLLLDL
dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform 2 precursor
Refseq ID NP_001231812
Protein GI 349585158
UniProt ID B7Z6J1
mRNA ID NM_001244883
Length 166
RefSeq Status REVIEWED
MLSRSRCVSRAFSRSLSAFQKGNCPLGRRSLPGVSLCQGPGYPNSRKVVINNSVFSVRFFRTTAVCKDDLVTVKTPAFAESVTEGDVRWEKAVGDTVAEDEVVCEIETDKTSVQVPSPANGVIEALLVPDGGKVEGGTPLFTLRKTGGKEVLLVVKVSSVPSWDWD

Gene Information

Entrez Gene ID
1743
Gene Name
dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
Gene Symbol
DLST
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0016020 IDA:UniProtKB C membrane
GO:0005759 TAS:Reactome C mitochondrial matrix
GO:0005634 IDA:UniProt C nucleus
GO:0045252 IEA:InterPro C oxoglutarate dehydrogenase complex
GO:0004149 IEA:UniProtKB-EC F dihydrolipoyllysine-residue succinyltransferase activity
GO:0033512 IEA:UniProtKB-UniPathway P L-lysine catabolic process to acetyl-CoA via saccharopine
GO:0044237 TAS:Reactome P cellular metabolic process
GO:0034641 TAS:Reactome P cellular nitrogen compound metabolic process
GO:0006091 TAS:ProtInc P generation of precursor metabolites and energy
GO:0006554 TAS:Reactome P lysine catabolic process
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0006099 TAS:Reactome P tricarboxylic acid cycle

KEGG Pathway Links

KEGG Pathway ID Description
hsa01200 Carbon metabolism
hsa00020 Citrate cycle (TCA cycle)

Domain Information

InterPro Annotations

Accession Description
IPR003016 2-oxo acid dehydrogenase, lipoyl-binding site
IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain
IPR000089 Biotin/lipoyl attachment
IPR023213 Chloramphenicol acetyltransferase-like domain
IPR006255 Dihydrolipoamide succinyltransferase
IPR011053 Single hybrid motif

UniProt Annotations

Entry Information

Gene Name
dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
Protein Entry
ODO2_HUMAN
UniProt ID
P36957
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P36957-1; Sequence=Displayed; Name=2; IsoId=P36957-2; Sequence=VSP_056439, VSP_056440; Note=No experimental confirmation available.;
Catalytic Activity Succinyl-CoA + enzyme N(6)- (dihydrolipoyl)lysine = CoA + enzyme N(6)-(S- succinyldihydrolipoyl)lysine.
Cofactor Name=(R)-lipoate; Xref=ChEBI
Function The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).
Pathway Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.
Similarity Belongs to the 2-oxoacid dehydrogenase family.
Similarity Contains 1 lipoyl-binding domain.
Subcellular Location Mitochondrion.
Subunit Forms a 24-polypeptide structural core with octahedral symmetry.

Identical and Related Proteins

Unique RefSeq proteins for LMP001853 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
19923748 RefSeq NP_001924 453 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform 1 precursor
349585158 RefSeq NP_001231812 166 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform 2 precursor

Identical Sequences to LMP001853 proteins

Reference Database Accession Length Protein Name
GI:349585158 DBBJ BAH13277.1 166 unnamed protein product [Homo sapiens]
GI:19923748 GenBank ADQ32761.1 453 dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex), partial [synthetic construct]
GI:19923748 GenBank JAA10505.1 453 dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) [Pan troglodytes]
GI:19923748 GenBank JAA14171.1 453 dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) [Pan troglodytes]
GI:19923748 GenBank JAA41855.1 453 dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) [Pan troglodytes]
GI:19923748 GenBank AIC54281.1 453 DLST, partial [synthetic construct]
GI:19923748 SwissProt P36957.4 453 RecName: Full=Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial; AltName: Full=2-oxoglutarate dehydrogenase complex component E2; Short=OGDC-E2; AltName: Full=Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; AltName: Full=E2K; Flags: Precursor [Homo sapiens]

Related Sequences to LMP001853 proteins

Reference Database Accession Length Protein Name
GI:19923748 EMBL CAG33008.1 453 DLST [Homo sapiens]
GI:19923748 GenBank AAB59629.1 453 dihydrolipoamide succinyltransferase [Homo sapiens]
GI:19923748 GenBank JAA32666.1 453 dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) [Pan troglodytes]
GI:349585158 GenBank JAB08853.1 167 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform 2 precursor [Callithrix jacchus]
GI:349585158 GenBank JAB15851.1 167 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform 2 precursor [Callithrix jacchus]
GI:349585158 GenBank JAB28981.1 167 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform 2 precursor [Callithrix jacchus]
GI:349585158 GenBank JAB37716.1 167 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform 2 precursor [Callithrix jacchus]
GI:349585158 GenBank JAB46352.1 167 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform 2 precursor [Callithrix jacchus]
GI:19923748 RefSeq XP_510068.2 453 PREDICTED: dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform X1 [Pan troglodytes]
GI:19923748 RefSeq XP_002824992.1 453 PREDICTED: dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial [Pongo abelii]
GI:19923748 RefSeq XP_003824220.1 453 PREDICTED: dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial [Pan paniscus]
GI:349585158 RefSeq XP_004324397.1 167 PREDICTED: dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial-like [Tursiops truncatus]