Gene/Proteome Database (LMPD)

LMPD ID
LMP001866
Gene ID
2526
Species
Homo sapiens (Human)
Gene Name
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
Gene Symbol
FUT4
Synonyms
CD15; ELFT; FCT3A; FUC-TIV; FUTIV; LeX; SSEA-1
Alternate Names
alpha-(1,3)-fucosyltransferase 4; Lewis X; fucT-IV; fucosyltransferase IV; ELAM ligand fucosyltransferase; ELAM-1 ligand fucosyltransferase; galactoside 3-L-fucosyltransferase; stage-specific embryonic antigen 1
Chromosome
11
Map Location
11q21
EC Number
2.4.1.-
Summary
The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15). [provided by RefSeq, Jan 2009]
Orthologs
View orthologs and multiple alignments for FUT4

Proteins

alpha-(1,3)-fucosyltransferase 4
Refseq ID NP_002024
Protein GI 4503811
UniProt ID P22083
mRNA ID NM_002033
Length 530
RefSeq Status REVIEWED
MRRLWGAARKPSGAGWEKEWAEAPQEAPGAWSGRLGPGRSGRKGRAVPGWASWPAHLALAARPARHLGGAGQGPRPLHSGTAPFHSRASGERQRRLEPQLQHESRCRSSTPADAWRAEAALPVRAMGAPWGSPTAAAGGRRGWRRGRGLPWTVCVLAAAGLTCTALITYACWGQLPPLPWASPTPSRPVGVLLWWEPFGGRDSAPRPPPDCRLRFNISGCRLLTDRASYGEAQAVLFHHRDLVKGPPDWPPPWGIQAHTAEEVDLRVLDYEEAAAAAEALATSSPRPPGQRWVWMNFESPSHSPGLRSLASNLFNWTLSYRADSDVFVPYGYLYPRSHPGDPPSGLAPPLSRKQGLVAWVVSHWDERQARVRYYHQLSQHVTVDVFGRGGPGQPVPEIGLLHTVARYKFYLAFENSQHLDYITEKLWRNALLAGAVPVVLGPDRANYERFVPRGAFIHVDDFPSASSLASYLLFLDRNPAVYRRYFHWRRSYAVHITSFWDEPWCRVCQAVQRAGDRPKSIRNLASWFER

Gene Information

Entrez Gene ID
2526
Gene Name
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
Gene Symbol
FUT4
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 TAS:UniProtKB C Golgi apparatus
GO:0071944 IEA:Ensembl C cell periphery
GO:0009986 IEA:Ensembl C cell surface
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016020 TAS:ProtInc C membrane
GO:0046920 TAS:UniProtKB F alpha-(1->3)-fucosyltransferase activity
GO:0008417 TAS:ProtInc F fucosyltransferase activity
GO:0042355 NAS:UniProtKB P L-fucose catabolic process
GO:0005975 TAS:ProtInc P carbohydrate metabolic process
GO:0036065 TAS:GOC P fucosylation
GO:0006486 TAS:UniProtKB P protein glycosylation

KEGG Pathway Links

KEGG Pathway ID Description
hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series
hsa01100 Metabolic pathways
hsa00514 Other types of O-glycan biosynthesis
ko00514 Other types of O-glycan biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR001503 Glycosyl transferase, family 10

UniProt Annotations

Entry Information

Gene Name
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
Protein Entry
FUT4_HUMAN
UniProt ID
P22083
Species
Human

Comments

Comment Type Description
Caution It is uncertain whether Met-1 or Met-126 is the initiator.
Function May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens.
Pathway Protein modification; protein glycosylation.
Sequence Caution Sequence=AAB20349.1; Type=Frameshift; Positions=114; Evidence= ;
Similarity Belongs to the glycosyltransferase 10 family.
Subcellular Location Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.
Web Resource Name=Functional Glycomics Gateway - GTase; Note=Fucosyltransferase 4; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_601";
Web Resource Name=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=FUT4";

Identical and Related Proteins

Unique RefSeq proteins for LMP001866 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
4503811 RefSeq NP_002024 530 alpha-(1,3)-fucosyltransferase 4

Identical Sequences to LMP001866 proteins

Reference Database Accession Length Protein Name
GI:4503811 EMBL CAA01413.1 530 protein 1 [synthetic construct]
GI:4503811 EMBL CDM22275.1 530 unnamed protein product [Homo sapiens]
GI:4503811 GenBank EAW66938.1 530 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) [Homo sapiens]
GI:4503811 GenBank AAI36375.1 530 Fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) [Homo sapiens]
GI:4503811 GenBank AAI36374.1 530 Fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) [Homo sapiens]
GI:4503811 SwissProt P22083.3 530 RecName: Full=Alpha-(1,3)-fucosyltransferase 4; AltName: Full=ELAM-1 ligand fucosyltransferase; AltName: Full=Fucosyltransferase 4; AltName: Full=Fucosyltransferase IV; Short=Fuc-TIV; Short=FucT-IV; AltName: Full=Galactoside 3-L-fucosyltransferase [Homo sapiens]

Related Sequences to LMP001866 proteins

Reference Database Accession Length Protein Name
GI:4503811 GenBank JAA05290.1 530 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) [Pan troglodytes]
GI:4503811 RefSeq NP_001008985.2 530 alpha-(1,3)-fucosyltransferase 4 [Pan troglodytes]
GI:4503811 RefSeq XP_003813844.1 530 PREDICTED: alpha-(1,3)-fucosyltransferase 4 [Pan paniscus]
GI:4503811 RefSeq XP_004052043.1 512 PREDICTED: alpha-(1,3)-fucosyltransferase-like [Gorilla gorilla gorilla]
GI:4503811 RefSeq XP_008018770.1 531 PREDICTED: alpha-(1,3)-fucosyltransferase 4 [Chlorocebus sabaeus]
GI:4503811 SwissProt Q659K9.2 530 RecName: Full=Alpha-(1,3)-fucosyltransferase 4; AltName: Full=Fucosyltransferase 4; AltName: Full=Fucosyltransferase IV; Short=Fuc-TIV; Short=FucT-IV; AltName: Full=Galactoside 3-L-fucosyltransferase [Pan troglodytes]