Gene/Proteome Database (LMPD)
LMPD ID
LMP001995
Gene ID
Species
Homo sapiens (Human)
Gene Name
thromboxane A2 receptor
Gene Symbol
Synonyms
BDPLT13; TXA2-R
Alternate Names
thromboxane A2 receptor; prostanoid TP receptor
Chromosome
19
Map Location
19p13.3
Summary
This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Orthologs
Proteins
| thromboxane A2 receptor isoform alpha | |
|---|---|
| Refseq ID | NP_001051 |
| Protein GI | 4507381 |
| UniProt ID | P21731 |
| mRNA ID | NM_001060 |
| Length | 343 |
| RefSeq Status | REVIEWED |
| MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ | |
| thromboxane A2 receptor isoform beta | |
|---|---|
| Refseq ID | NP_963998 |
| Protein GI | 260593681 |
| UniProt ID | P21731 |
| mRNA ID | NM_201636 |
| Length | 407 |
| RefSeq Status | REVIEWED |
| MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRRSLTLWPSLEYSGTISAHCNLRLPGSSDSRASASRAAGITGVSHCARPCMLFDPEFDLLAGVQLLPFEPPTGKALSRKD | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0001669 | IEA:Ensembl | C | acrosomal vesicle |
| GO:0005887 | TAS:ProtInc | C | integral component of plasma membrane |
| GO:0005886 | TAS:Reactome | C | plasma membrane |
| GO:0005085 | TAS:Reactome | F | guanyl-nucleotide exchange factor activity |
| GO:0004961 | TAS:ProtInc | F | thromboxane A2 receptor activity |
| GO:0007186 | TAS:ProtInc | P | G-protein coupled receptor signaling pathway |
| GO:0007596 | TAS:Reactome | P | blood coagulation |
| GO:0006954 | IEA:Ensembl | P | inflammatory response |
| GO:0030168 | TAS:Reactome | P | platelet activation |
| GO:0043547 | TAS:GOC | P | positive regulation of GTPase activity |
| GO:0045766 | IEA:Ensembl | P | positive regulation of angiogenesis |
| GO:0045777 | IEA:Ensembl | P | positive regulation of blood pressure |
| GO:0007204 | IEA:Ensembl | P | positive regulation of cytosolic calcium ion concentration |
| GO:0045987 | IEA:Ensembl | P | positive regulation of smooth muscle contraction |
| GO:0045907 | IEA:Ensembl | P | positive regulation of vasoconstriction |
| GO:0042493 | IEA:Ensembl | P | response to drug |
| GO:0032496 | IEA:Ensembl | P | response to lipopolysaccharide |
| GO:0007584 | IEA:Ensembl | P | response to nutrient |
| GO:0019932 | IEA:Ensembl | P | second-messenger-mediated signaling |
| GO:0038193 | TAS:GOC | P | thromboxane A2 signaling pathway |
KEGG Pathway Links
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_20647 | Thromboxane signalling through TP receptor |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Alpha; IsoId=P21731-3; Sequence=Displayed; Name=2; Synonyms=Beta; IsoId=P21731-2; Sequence=VSP_001925; Note=Ref.2 (AAA58957) sequence differs from that shown due to frameshifts in positions 330 and 386. ; |
| Disease | Bleeding disorder, platelet-type 13 (BDPLT13) [MIM |
| Function | Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase. |
| Interaction | Q13162:PRDX4; NbExp=3; IntAct=EBI-2625082, EBI-2211957; |
| Sequence Caution | Sequence=AAA58957.1; Type=Frameshift; Positions=329; Evidence= ; |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Subunit | Interacts with RPGRIP1L. Interacts with PSMA3. Interacts with GNB2L1/RACK1; the interaction regulates TBXA2R cell surface expression. {ECO |
| Web Resource | Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/tbxa2r/"; |
Identical and Related Proteins
Unique RefSeq proteins for LMP001995 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 4507381 | RefSeq | NP_001051 | 343 | thromboxane A2 receptor isoform alpha |
| 260593681 | RefSeq | NP_963998 | 407 | thromboxane A2 receptor isoform beta |
Identical Sequences to LMP001995 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:260593681 | GenBank | AAC24302.1 | 407 | TA2R_HUMAN, BETA ISOFORM [Homo sapiens] |
| GI:4507381 | GenBank | AAH74749.1 | 343 | Thromboxane A2 receptor [Homo sapiens] |
| GI:4507381 | GenBank | ABB72549.1 | 343 | thromboxane A2 receptor [Homo sapiens] |
| GI:260593681 | GenBank | EAW69301.1 | 407 | thromboxane A2 receptor, isoform CRA_a, partial [Homo sapiens] |
| GI:4507381 | GenBank | EAW69302.1 | 343 | thromboxane A2 receptor, isoform CRA_b [Homo sapiens] |
| GI:260593681 | GenBank | ABU34403.1 | 407 | Sequence 104 from patent US 7241738 |
| GI:4507381 | GenBank | ACC29795.1 | 343 | Sequence 105 from patent US 7348140 |
| GI:4507381 | GenBank | AFA67227.1 | 343 | Sequence 2 from patent US 8101371 |
| GI:4507381 | SwissProt | P21731.3 | 343 | RecName: Full=Thromboxane A2 receptor; Short=TXA2-R; AltName: Full=Prostanoid TP receptor [Homo sapiens] |
Related Sequences to LMP001995 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:260593681 | DBBJ | BAA03649.1 | 343 | thromboxane A2 receptor [Homo sapiens] |
| GI:260593681 | DBBJ | BAA07274.1 | 343 | thromboxane A2 receptor [Homo sapiens] |
| GI:4507381 | GenBank | JAA06707.1 | 343 | thromboxane A2 receptor [Pan troglodytes] |
| GI:4507381 | GenBank | JAA19640.1 | 343 | thromboxane A2 receptor [Pan troglodytes] |
| GI:4507381 | GenBank | JAA24206.1 | 343 | thromboxane A2 receptor [Pan troglodytes] |
| GI:4507381 | GenBank | JAA33130.1 | 343 | thromboxane A2 receptor [Pan troglodytes] |
| GI:260593681 | PRF | - | 343 | thromboxane A2 receptor [Homo sapiens] |
| GI:4507381 | RefSeq | XP_524054.1 | 343 | PREDICTED: thromboxane A2 receptor [Pan troglodytes] |
| GI:4507381 | RefSeq | XP_002828489.1 | 343 | PREDICTED: thromboxane A2 receptor [Pongo abelii] |
| GI:260593681 | RefSeq | XP_003819304.2 | 407 | PREDICTED: LOW QUALITY PROTEIN: thromboxane A2 receptor [Pan paniscus] |
| GI:260593681 | RefSeq | XP_010365586.1 | 407 | PREDICTED: LOW QUALITY PROTEIN: thromboxane A2 receptor [Rhinopithecus roxellana] |
| GI:260593681 | SwissProt | P21731.3 | 343 | RecName: Full=Thromboxane A2 receptor; Short=TXA2-R; AltName: Full=Prostanoid TP receptor [Homo sapiens] |