Gene/Proteome Database (LMPD)

LMPD ID
LMP002003
Gene ID
5739
Species
Homo sapiens (Human)
Gene Name
prostaglandin I2 (prostacyclin) receptor (IP)
Gene Symbol
PTGIR
Synonyms
IP; PRIPR
Alternate Names
prostacyclin receptor; PGI receptor; PGI2 receptor; prostanoid IP receptor; prostaglandin I2 receptor
Chromosome
19
Map Location
19q13.3
Summary
The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for PTGIR

Proteins

prostacyclin receptor
Refseq ID NP_000951
Protein GI 4506263
UniProt ID P43119
mRNA ID NM_000960
Length 386
RefSeq Status REVIEWED
MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPLPPTQQSSGSAVGTSSKAEASVACSLC

Gene Information

Entrez Gene ID
5739
Gene Name
prostaglandin I2 (prostacyclin) receptor (IP)
Gene Symbol
PTGIR
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IDA:BHF-UCL C cytosol
GO:0005887 TAS:ProtInc C integral component of plasma membrane
GO:0005886 IDA:BHF-UCL C plasma membrane
GO:0004930 IEA:UniProtKB-KW F G-protein coupled receptor activity
GO:0005085 TAS:Reactome F guanyl-nucleotide exchange factor activity
GO:0007187 TAS:ProtInc P G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007189 IMP:BHF-UCL P adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007596 TAS:Reactome P blood coagulation
GO:0007267 TAS:ProtInc P cell-cell signaling
GO:0010642 ISS:BHF-UCL P negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0048662 IDA:BHF-UCL P negative regulation of smooth muscle cell proliferation
GO:0043547 TAS:GOC P positive regulation of GTPase activity
GO:0030819 IMP:BHF-UCL P positive regulation of cAMP biosynthetic process
GO:0043950 IMP:BHF-UCL P positive regulation of cAMP-mediated signaling
GO:0032496 IEA:Ensembl P response to lipopolysaccharide

KEGG Pathway Links

KEGG Pathway ID Description
hsa04611 Platelet activation
hsa04270 Vascular smooth muscle contraction

Domain Information

InterPro Annotations

Accession Description
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
IPR000370 Prostacyclin (prostanoid IP) receptor
IPR008365 Prostanoid receptor

UniProt Annotations

Entry Information

Gene Name
prostaglandin I2 (prostacyclin) receptor (IP)
Protein Entry
PI2R_HUMAN
UniProt ID
P43119
Species
Human

Comments

Comment Type Description
Function Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.
Ptm Isoprenylation does not influence ligand binding but is required for efficient coupling to the effectors adenylyl cyclase and phospholipase C.
Ptm Palmitoylation of either Cys-308 or Cys-311 is sufficient to maintain functional coupling to G(s) and signaling.
Similarity Belongs to the G-protein coupled receptor 1 family.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Subunit Interacts (non-isoprenylated C-terminus) with PDZK1.

Identical and Related Proteins

Unique RefSeq proteins for LMP002003 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
4506263 RefSeq NP_000951 386 prostacyclin receptor

Identical Sequences to LMP002003 proteins

Reference Database Accession Length Protein Name
GI:4506263 DBBJ BAG74563.1 386 prostaglandin I2 receptor, partial [synthetic construct]
GI:4506263 EMBL CAH05338.1 386 unnamed protein product [Homo sapiens]
GI:4506263 GenBank AAH75814.1 386 Prostaglandin I2 (prostacyclin) receptor (IP) [Homo sapiens]
GI:4506263 GenBank EAW57432.1 386 prostaglandin I2 (prostacyclin) receptor (IP), isoform CRA_a [Homo sapiens]
GI:4506263 GenBank AFX21882.1 386 Sequence 9 from patent US 8299043
GI:4506263 GenBank AIC54986.1 386 PTGIR, partial [synthetic construct]

Related Sequences to LMP002003 proteins

Reference Database Accession Length Protein Name
GI:4506263 DBBJ BAG37688.1 386 unnamed protein product [Homo sapiens]
GI:4506263 GenBank AAI10343.1 386 Prostaglandin I2 (prostacyclin) receptor (IP) [Homo sapiens]
GI:4506263 GenBank JAA02682.1 386 prostaglandin I2 (prostacyclin) receptor (IP) [Pan troglodytes]
GI:4506263 GenBank JAA20714.1 386 prostaglandin I2 (prostacyclin) receptor (IP) [Pan troglodytes]
GI:4506263 GenBank JAA32172.1 386 prostaglandin I2 (prostacyclin) receptor (IP) [Pan troglodytes]
GI:4506263 GenBank JAA34337.1 386 prostaglandin I2 (prostacyclin) receptor (IP) [Pan troglodytes]