Gene/Proteome Database (LMPD)

LMPD ID
LMP002077
Gene ID
79837
Species
Homo sapiens (Human)
Gene Name
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
Gene Symbol
PIP4K2C
Synonyms
PIP5K2C
Alternate Names
phosphatidylinositol 5-phosphate 4-kinase type-2 gamma; PIP4KII-gamma; PI(5)P 4-kinase type II gamma; phosphatidylinositol 4-phosphate 5-kinase; phosphatidylinositol-5-phosphate 4-kinase type-2 gamma; phosphatidylinositol 5-phosphate 4-kinase type II gamma; phosphatidylinositol-4-phosphate 5-kinase, type II, gamma
Chromosome
12
Map Location
12q13.3
EC Number
2.7.1.149

Proteins

phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform a
Refseq ID NP_079055
Protein GI 226371737
UniProt ID Q8TBX8
mRNA ID NM_024779
Length 421
RefSeq Status VALIDATED
MASSSVPPATVSAATAGPGPGFGFASKTKKKHFVQQKVKVFRAADPLVGVFLWGVAHSINELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAGAEISTVHPEQYAKRFLDFITNIFA
phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform a
Refseq ID NP_001139730
Protein GI 226371739
UniProt ID Q8TBX8
mRNA ID NM_001146258
Length 421
RefSeq Status VALIDATED
Protein sequence is identical to GI:226371737 (mRNA isoform)
phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform b
Refseq ID NP_001139731
Protein GI 226371741
UniProt ID Q8TBX8
mRNA ID NM_001146259
Length 403
RefSeq Status VALIDATED
MASSSVPPATVSAATAGPGPGFGFASKTKKKHFVQQKVKVFRAADPLVGVFLWGVAHSINELSQVPPPVMLLPDDFKASSKIKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAGAEISTVHPEQYAKRFLDFITNIFA
phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform c
Refseq ID NP_001139732
Protein GI 226371743
UniProt ID Q8TBX8
mRNA ID NM_001146260
Length 373
RefSeq Status VALIDATED
MASSSVPPATVSAATAGPGPGFGFASKTKKKHFVQQKVKVFRAADPLVGVFLWGVAHSINELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAGAEISTVHPEQYAKRFLDFITNIFA

Gene Information

Entrez Gene ID
79837
Gene Name
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
Gene Symbol
PIP4K2C
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0016309 IEA:UniProtKB-EC F 1-phosphatidylinositol-5-phosphate 4-kinase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0042802 IPI:IntAct F identical protein binding

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6351 D-myo-inositol (1,4,5)-trisphosphate biosynthesis
PWY-6367 D-myo-inositol-5-phosphate metabolism

Domain Information

InterPro Annotations

Accession Description
IPR023610 Phosphatidylinositol-4-phosphate 5-kinase
IPR027483 Phosphatidylinositol-4-phosphate 5-kinase, C-terminal
IPR027484 Phosphatidylinositol-4-phosphate 5-kinase, N-terminal domain
IPR002498 Phosphatidylinositol-4-phosphate 5-kinase, core
IPR016034 Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
Protein Entry
PI42C_HUMAN
UniProt ID
Q8TBX8
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8TBX8-1; Sequence=Displayed; Name=2; IsoId=Q8TBX8-2; Sequence=VSP_042929; Note=No experimental confirmation available.; Name=3; IsoId=Q8TBX8-3; Sequence=VSP_043369; Note=No experimental confirmation available.;
Catalytic Activity ATP + 1-phosphatidyl-1D-myo-inositol 5- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
Function May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum.
Interaction Self; NbExp=2; IntAct=EBI-1383637, EBI-1383637;
Sequence Caution Sequence=BAB15223.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ;
Similarity Contains 1 PIPK domain. {ECO
Subcellular Location Cytoplasm. Membrane. Note=Mostly found in the cytosol and surrounding plasma membrane. However, its presence in the endoplasmic reticulum seems to be a prerequisite for PIP2 synthesis (By similarity).

Identical and Related Proteins

Unique RefSeq proteins for LMP002077 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
226371737 RefSeq NP_079055 421 phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform a
226371741 RefSeq NP_001139731 403 phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform b
226371743 RefSeq NP_001139732 373 phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform c

Identical Sequences to LMP002077 proteins

Reference Database Accession Length Protein Name
GI:226371737 DBBJ BAG37960.1 421 unnamed protein product [Homo sapiens]
GI:226371741 DBBJ BAG63606.1 403 unnamed protein product [Homo sapiens]
GI:226371743 DBBJ BAG59723.1 373 unnamed protein product [Homo sapiens]
GI:226371737 GenBank ABH71188.1 421 Sequence 158 from patent US 7033790
GI:226371737 GenBank EAW97031.1 421 phosphatidylinositol-4-phosphate 5-kinase, type II, gamma [Homo sapiens]
GI:226371737 GenBank ADL72965.1 421 Sequence 6 from patent US 7696316
GI:226371737 RefSeq NP_001139730.1 421 phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform a [Homo sapiens]
GI:226371737 SwissProt Q8TBX8.3 421 RecName: Full=Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma; AltName: Full=Phosphatidylinositol 5-phosphate 4-kinase type II gamma; Short=PI(5)P 4-kinase type II gamma; Short=PIP4KII-gamma [Homo sapiens]

Related Sequences to LMP002077 proteins

Reference Database Accession Length Protein Name
GI:226371737 GenBank AAH28596.1 421 Phosphatidylinositol-5-phosphate 4-kinase, type II, gamma [Homo sapiens]
GI:226371737 GenBank ABM85608.1 421 phosphatidylinositol-4-phosphate 5-kinase, type II, gamma, partial [synthetic construct]
GI:226371737 GenBank AHD74723.1 421 Sequence 14740 from patent US 8586006
GI:226371737 RefSeq XP_003313599.1 421 PREDICTED: phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1 [Pan troglodytes]
GI:226371741 RefSeq XP_004401791.1 403 PREDICTED: phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform 2 [Odobenus rosmarus divergens]
GI:226371743 RefSeq XP_004401792.1 373 PREDICTED: phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform 3 [Odobenus rosmarus divergens]
GI:226371743 RefSeq XP_004429380.1 373 PREDICTED: phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform 4 [Ceratotherium simum simum]
GI:226371741 RefSeq XP_004583014.1 403 PREDICTED: phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X2 [Ochotona princeps]
GI:226371743 RefSeq XP_004583015.1 373 PREDICTED: phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X3 [Ochotona princeps]
GI:226371741 RefSeq XP_004773297.1 403 PREDICTED: phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X2 [Mustela putorius furo]
GI:226371743 RefSeq XP_004773298.1 373 PREDICTED: phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X3 [Mustela putorius furo]
GI:226371741 RefSeq XP_004800787.1 403 PREDICTED: phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X2 [Mustela putorius furo]
GI:226371743 RefSeq XP_004800788.1 373 PREDICTED: phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X3 [Mustela putorius furo]
GI:226371741 RefSeq XP_005571425.1 403 PREDICTED: phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X3 [Macaca fascicularis]
GI:226371743 RefSeq XP_005571426.1 373 PREDICTED: phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X4 [Macaca fascicularis]
GI:226371741 RefSeq XP_008976738.1 421 PREDICTED: LOW QUALITY PROTEIN: phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [Pan paniscus]
GI:226371737 RefSeq XP_008976738.1 421 PREDICTED: LOW QUALITY PROTEIN: phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [Pan paniscus]
GI:226371737 RefSeq XP_009423333.1 421 PREDICTED: phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1 [Pan troglodytes]