Gene/Proteome Database (LMPD)

LMPD ID
LMP002181
Gene ID
15490
Species
Mus musculus (Mouse)
Gene Name
hydroxysteroid (17-beta) dehydrogenase 7
Gene Symbol
Hsd17b7
Synonyms
AI266814; ERG27
Alternate Names
3-keto-steroid reductase; 17-beta-HSD 7; estradiol 17-beta-dehydrogenase 7; 17-beta-hydroxysteroid dehydrogenase 7
Chromosome
1
Map Location
1 H3|1
EC Number
1.1.1.270

Proteins

3-keto-steroid reductase
Refseq ID NP_034606
Protein GI 87162470
UniProt ID O88736
mRNA ID NM_010476
Length 334
RefSeq Status VALIDATED
MRKVVLITGASSGIGLALCGRLLAEDDDLHLCLACRNLSKARAVRDTLLASHPSAEVSIVQMDVSSLQSVVRGAEEVKQKFQRLDYLYLNAGILPNPQFNLKAFFCGIFSRNVIHMFTTAEGILTQNDSVTADGLQEVFETNLFGHFILIRELEPLLCHADNPSQLIWTSSRNAKKANFSLEDIQHSKGPEPYSSSKYATDLLNVALNRNFNQKGLYSSVMCPGVVMTNMTYGILPPFIWTLLLPIMWLLRFFVNALTVTPYNGAEALVWLFHQKPESLNPLTKYASATSGFGTNYVTGQKMDIDEDTAEKFYEVLLELEKRVRTTVQKSDHPS

Gene Information

Entrez Gene ID
15490
Gene Name
hydroxysteroid (17-beta) dehydrogenase 7
Gene Symbol
Hsd17b7
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:MGI C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0000253 IDA:MGI F 3-keto sterol reductase activity
GO:0004303 IEA:UniProtKB-EC F estradiol 17-beta-dehydrogenase activity
GO:0006695 IDA:MGI P cholesterol biosynthetic process
GO:0006703 IEA:UniProtKB-UniPathway P estrogen biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu04913 Ovarian steroidogenesis
mmu00100 Steroid biosynthesis
mmu00140 Steroid hormone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR002347 Glucose/ribitol dehydrogenase
IPR016040 NAD(P)-binding domain
IPR002198 Short-chain dehydrogenase/reductase SDR

UniProt Annotations

Entry Information

Gene Name
hydroxysteroid (17-beta) dehydrogenase 7
Protein Entry
DHB7_MOUSE
UniProt ID
O88736
Species
Mouse

Comments

Comment Type Description
Catalytic Activity 17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
Catalytic Activity A 3-beta-hydroxysteroid + NADP(+) = a 3- oxosteroid + NADPH.
Function Responsible for the reduction of the keto group on the C-3 of sterols.
Pathway Steroid biosynthesis; estrogen biosynthesis.
Pathway Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 5/6.
Similarity Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily. {ECO:0000305}.
Subcellular Location Cell membrane; Single-pass membrane protein.
Tissue Specificity Most abundant in ovaries of pregnant animals. Present also in nonpregnant animals in ovaries, mammary gland, liver, kidney and testis.

Identical and Related Proteins

Unique RefSeq proteins for LMP002181 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
87162470 RefSeq NP_034606 334 3-keto-steroid reductase

Identical Sequences to LMP002181 proteins

Reference Database Accession Length Protein Name
GI:87162470 DBBJ BAC34124.1 334 unnamed protein product [Mus musculus]
GI:87162470 DBBJ BAC25918.1 334 unnamed protein product [Mus musculus]
GI:87162470 EMBL CAA75742.1 334 17-beta-hydroxysteroid dehydrogenase type 7 [Mus musculus]
GI:87162470 GenBank ABI05591.1 334 Sequence 32 from patent US 7078169
GI:87162470 GenBank AEW41340.1 334 Sequence 4 from patent US 8076102
GI:87162470 SwissProt O88736.1 334 RecName: Full=3-keto-steroid reductase; AltName: Full=17-beta-hydroxysteroid dehydrogenase 7; Short=17-beta-HSD 7; AltName: Full=Estradiol 17-beta-dehydrogenase 7 [Mus musculus]

Related Sequences to LMP002181 proteins

Reference Database Accession Length Protein Name
GI:87162470 EMBL CAC88119.1 334 17beta-hydroxysteroid dehydrogenase type 7 [Mus musculus]
GI:87162470 GenBank ABI05597.1 334 Sequence 43 from patent US 7078169
GI:87162470 GenBank EDL39168.1 334 hydroxysteroid (17-beta) dehydrogenase 7, isoform CRA_b [Mus musculus]
GI:87162470 RefSeq NP_058931.1 334 3-keto-steroid reductase [Rattus norvegicus]
GI:87162470 RefSeq XP_006496730.1 315 PREDICTED: 3-keto-steroid reductase isoform X1 [Mus musculus]
GI:87162470 SwissProt Q62904.1 334 RecName: Full=3-keto-steroid reductase; AltName: Full=17-beta-hydroxysteroid dehydrogenase 7; Short=17-beta-HSD 7; AltName: Full=Estradiol 17-beta-dehydrogenase 7; AltName: Full=PRL receptor-associated protein; Short=PRAP [Rattus norvegicus]