Gene/Proteome Database (LMPD)

LMPD ID
LMP002292
Gene ID
1573
Species
Homo sapiens (Human)
Gene Name
cytochrome P450, family 2, subfamily J, polypeptide 2
Gene Symbol
CYP2J2
Synonyms
CPJ2
Alternate Names
cytochrome P450 2J2; CYPIIJ2; microsomal monooxygenase; arachidonic acid epoxygenase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily IIJ (arachidonic acid epoxygenase) polypeptide 2
Chromosome
1
Map Location
1p31.3-p31.2
EC Number
1.14.14.1
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for CYP2J2

Proteins

cytochrome P450 2J2
Refseq ID NP_000766
Protein GI 18491008
UniProt ID P51589
mRNA ID NM_000775
Length 502
RefSeq Status REVIEWED
MLAAMGSLAAALWAVVHPRTLLLGTVAFLLAADFLKRRRPKNYPPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLENGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLKFRMGITISPVSHRLCAVPQV

Gene Information

Entrez Gene ID
1573
Gene Name
cytochrome P450, family 2, subfamily J, polypeptide 2
Gene Symbol
CYP2J2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0008405 IDA:BHF-UCL F arachidonic acid 11,12-epoxygenase activity
GO:0008404 IDA:BHF-UCL F arachidonic acid 14,15-epoxygenase activity
GO:0008392 IDA:BHF-UCL F arachidonic acid epoxygenase activity
GO:0070330 IEA:UniProtKB-EC F aromatase activity
GO:0020037 IEA:InterPro F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0071614 IDA:BHF-UCL F linoleic acid epoxygenase activity
GO:0019369 TAS:Reactome P arachidonic acid metabolic process
GO:0019373 IDA:BHF-UCL P epoxygenase P450 pathway
GO:0006690 TAS:ProtInc P icosanoid metabolic process
GO:0043651 IDA:BHF-UCL P linoleic acid metabolic process
GO:0008016 TAS:ProtInc P regulation of heart contraction
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0006805 TAS:BHF-UCL P xenobiotic metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa04750 Inflammatory mediator regulation of TRP channels
hsa04913 Ovarian steroidogenesis
hsa04726 Serotonergic synapse

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR008071 Cytochrome P450, E-class, group I, CYP2J-like
IPR017972 Cytochrome P450, conserved site

UniProt Annotations

Entry Information

Gene Name
cytochrome P450, family 2, subfamily J, polypeptide 2
Protein Entry
CP2J2_HUMAN
UniProt ID
P51589
Species
Human

Comments

Comment Type Description
Catalytic Activity RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.
Cofactor Name=heme; Xref=ChEBI
Function This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools.
Similarity Belongs to the cytochrome P450 family.
Subcellular Location Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue Specificity Highly expressed in heart, present at lower levels in liver, ileum, jejunum, colon, and kidney.
Web Resource Name=Cytochrome P450 Allele Nomenclature Committee; Note=CYP2J2 alleles; URL="http://www.cypalleles.ki.se/cyp2j2.htm";
Web Resource Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cyp2j2/";

Identical and Related Proteins

Unique RefSeq proteins for LMP002292 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18491008 RefSeq NP_000766 502 cytochrome P450 2J2

Identical Sequences to LMP002292 proteins

Reference Database Accession Length Protein Name
GI:18491008 GenBank ADA19488.1 502 Sequence 1312 from patent US 7608413
GI:18491008 GenBank ADA19489.1 502 Sequence 1313 from patent US 7608413
GI:18491008 GenBank AEN35384.1 502 Sequence 1312 from patent US 7998689
GI:18491008 GenBank AEN35385.1 502 Sequence 1313 from patent US 7998689
GI:18491008 GenBank AHD70780.1 502 Sequence 4248 from patent US 8586006
GI:18491008 GenBank AIC48607.1 502 CYP2J2, partial [synthetic construct]

Related Sequences to LMP002292 proteins

Reference Database Accession Length Protein Name
GI:18491008 DBBJ BAB85489.1 502 cytochrome P450 2J2 [Homo sapiens]
GI:18491008 GenBank ACM80493.1 502 Sequence 5991 from patent US 6812339
GI:18491008 GenBank ADR87094.1 502 Sequence 362 from patent US 7740664
GI:18491008 RefSeq XP_001082853.1 502 PREDICTED: cytochrome P450 2J2-like [Macaca mulatta]
GI:18491008 RefSeq XP_008976229.1 506 PREDICTED: cytochrome P450 2J2 isoform X1 [Pan paniscus]
GI:18491008 RefSeq XP_009457276.1 502 PREDICTED: cytochrome P450 2J2 isoform X1 [Pan troglodytes]