Gene/Proteome Database (LMPD)

LMPD ID
LMP002316
Gene ID
138307
Species
Homo sapiens (Human)
Gene Name
lipocalin 8
Gene Symbol
LCN8
Synonyms
EP17; LCN5
Alternate Names
epididymal-specific lipocalin-8; lipocalin 5
Chromosome
9
Map Location
9q34.3
Summary
Members of the lipocalin family, such as LCN8, have a common structure consisting of an 8-stranded antiparallel beta-barrel that forms a cup-shaped ligand-binding pocket or calyx. Lipocalins generally bind small hydrophobic ligands and transport them to specific cells (Suzuki et al., 2004 [PubMed 15363845]).[supplied by OMIM, Aug 2009]
Orthologs
View orthologs and multiple alignments for LCN8

Proteins

epididymal-specific lipocalin-8
Refseq ID NP_848564
Protein GI 62988357
UniProt ID Q6JVE9
mRNA ID NM_178469
Length 152
RefSeq Status PROVISIONAL
MEELDRQKIGGFWREVGVASDQSLVLTAPKRVEGLFLTLSGSNLTVKVAYNSSGSCEIEKIVGSEIDSTGKFAFPGHREIHVLDTDYEGYAILRVSLMWRGRNFRVLKYFTRSLEDKDRLGFWKFRELTADTGLYLAARPGRCAELLKEELI

Gene Information

Entrez Gene ID
138307
Gene Name
lipocalin 8
Gene Symbol
LCN8
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005576 IEA:UniProtKB-KW C extracellular region
GO:0009725 IEA:Ensembl P response to hormone
GO:0006810 IEA:UniProtKB-KW P transport

Domain Information

InterPro Annotations

Accession Description
IPR012674 Calycin
IPR011038 Calycin-like
IPR000566 Lipocalin/cytosolic fatty-acid binding domain

UniProt Annotations

Entry Information

Gene Name
lipocalin 8
Protein Entry
LCN8_HUMAN
UniProt ID
Q6JVE9
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6JVE9-1; Sequence=Displayed; Name=2; IsoId=Q6JVE9-2; Sequence=VSP_040219;
Function May play a role in male fertility. May act as a retinoid carrier protein within the epididymis.
Sequence Caution Sequence=CAI12677.1; Type=Erroneous gene model prediction; Evidence= ;
Similarity Belongs to the calycin superfamily. Lipocalin family.
Subcellular Location Secreted .

Identical and Related Proteins

Unique RefSeq proteins for LMP002316 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
62988357 RefSeq NP_848564 152 epididymal-specific lipocalin-8

Identical Sequences to LMP002316 proteins

Reference Database Accession Length Protein Name
GI:62988357 GenBank EAW88265.1 152 lipocalin 8, isoform CRA_b [Homo sapiens]
GI:62988357 GenBank AAI30466.1 152 Lipocalin 8 [Homo sapiens]
GI:62988357 GenBank AAI32715.1 152 Lipocalin 8 [Homo sapiens]
GI:62988357 GenBank ADR83321.1 152 lipocalin 8 (LCN8), partial [synthetic construct]
GI:62988357 GenBank AIC53105.1 152 LCN8, partial [synthetic construct]

Related Sequences to LMP002316 proteins

Reference Database Accession Length Protein Name
GI:62988357 GenBank AHD66056.1 176 Sequence 4 from patent US 8580941
GI:62988357 RefSeq XP_002820445.1 226 PREDICTED: epididymal-specific lipocalin-8 isoform X1 [Pongo abelii]
GI:62988357 RefSeq XP_008968334.1 152 PREDICTED: epididymal-specific lipocalin-8 isoform X4 [Pan paniscus]
GI:62988357 RefSeq XP_008968335.1 159 PREDICTED: epididymal-specific lipocalin-8 isoform X5 [Pan paniscus]
GI:62988357 RefSeq XP_009456014.1 159 PREDICTED: epididymal-specific lipocalin-8 [Pan troglodytes]
GI:62988357 SwissProt Q6JVE9.1 175 RecName: Full=Epididymal-specific lipocalin-8; Flags: Precursor [Homo sapiens]