Gene/Proteome Database (LMPD)
LMPD ID
LMP002479
Gene ID
Species
Homo sapiens (Human)
Gene Name
leukotriene C4 synthase
Gene Symbol
Synonyms
-
Alternate Names
leukotriene C4 synthase; LTC4 synthase
Chromosome
5
Map Location
5q35
EC Number
4.4.1.20
Summary
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005783 | IDA:UniProtKB | C | endoplasmic reticulum |
| GO:0016021 | TAS:ProtInc | C | integral component of membrane |
| GO:0043231 | TAS:ProtInc | C | intracellular membrane-bounded organelle |
| GO:0005635 | IDA:UniProtKB | C | nuclear envelope |
| GO:0008047 | IEA:InterPro | F | enzyme activator activity |
| GO:0004602 | IBA:RefGenome | F | glutathione peroxidase activity |
| GO:0004364 | IBA:RefGenome | F | glutathione transferase activity |
| GO:0004464 | IDA:MGI | F | leukotriene-C4 synthase activity |
| GO:0008289 | IDA:MGI | F | lipid binding |
| GO:0019369 | TAS:Reactome | P | arachidonic acid metabolic process |
| GO:0019370 | IBA:RefGenome | P | leukotriene biosynthetic process |
| GO:0006691 | IDA:MGI | P | leukotriene metabolic process |
| GO:2001300 | TAS:Reactome | P | lipoxin metabolic process |
| GO:0019372 | TAS:Reactome | P | lipoxygenase pathway |
| GO:0055114 | IBA:GOC | P | oxidation-reduction process |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_150209 | Synthesis of 5-eicosatetraenoic acids |
| REACT_150420 | Synthesis of Leukotrienes (LT) and Eoxins (EX) |
| REACT_150320 | Synthesis of Lipoxins (LX) |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Leukotriene C(4) = leukotriene A(4) + glutathione. |
| Disease | Note=LTC4 synthase deficiency is associated with a neurometabolic developmental disorder characterized by muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly. |
| Function | Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4. |
| Similarity | Belongs to the MAPEG family. |
| Subcellular Location | Nucleus outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. |
| Subunit | Homotrimer. Interacts with ALOX5AP and ALOX5. {ECO |
| Tissue Specificity | Detected in lung, platelets and the myelogenous leukemia cell line KG-1 (at protein level). LTC4S activity is present in eosinophils, basophils, mast cells, certain phagocytic mononuclear cells, endothelial cells, vascular smooth muscle cells and platelets. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002479 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 22035629 | RefSeq | NP_665874 | 150 | leukotriene C4 synthase |
Identical Sequences to LMP002479 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:22035629 | EMBL | CAD12184.1 | 150 | unnamed protein product [Homo sapiens] |
| GI:22035629 | GenBank | AAB06723.1 | 150 | leukotriene C4 synthase [Homo sapiens] |
| GI:22035629 | GenBank | AAE26770.1 | 150 | Sequence 2 from patent US 5952210 |
| GI:22035629 | GenBank | ABA38401.1 | 150 | Sequence 2 from patent US 6939674 |
| GI:22035629 | GenBank | EAW53798.1 | 150 | leukotriene C4 synthase, isoform CRA_c [Homo sapiens] |
| GI:22035629 | SwissProt | Q16873.1 | 150 | RecName: Full=Leukotriene C4 synthase; Short=LTC4 synthase; AltName: Full=Leukotriene-C(4) synthase [Homo sapiens] |
Related Sequences to LMP002479 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:22035629 | GenBank | ACM85718.1 | 182 | Sequence 11216 from patent US 6812339 |
| GI:22035629 | PDB | 2PNO | 156 | Chain B, Crystal Structure Of Human Leukotriene C4 Synthase |
| GI:22035629 | PDB | 2PNO | 156 | Chain C, Crystal Structure Of Human Leukotriene C4 Synthase |
| GI:22035629 | PDB | 2PNO | 156 | Chain D, Crystal Structure Of Human Leukotriene C4 Synthase |
| GI:22035629 | PDB | 2PNO | 156 | Chain E, Crystal Structure Of Human Leukotriene C4 Synthase |
| GI:22035629 | PDB | 2PNO | 156 | Chain F, Crystal Structure Of Human Leukotriene C4 Synthase |