Gene/Proteome Database (LMPD)

LMPD ID
LMP002525
Gene ID
9451
Species
Homo sapiens (Human)
Gene Name
eukaryotic translation initiation factor 2-alpha kinase 3
Gene Symbol
EIF2AK3
Synonyms
PEK; PERK; WRS
Chromosome
2
Map Location
2p12
Summary
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Jan 2010]
Orthologs
View orthologs and multiple alignments for EIF2AK3

Proteins

eukaryotic translation initiation factor 2-alpha kinase 3 precursor
Refseq ID NP_004827
Protein GI 134304838
UniProt ID Q9NZJ5
mRNA ID NM_004836
Length 1116
RefSeq Status REVIEWED
MERAISPGLLVRALLLLLLLLGLAARTVAAGRARGLPAPTAEAAFGLGAAAAPTSATRVPAAGAVAAAEVTVEDAEALPAAAGEQEPRGPEPDDETELRPRGRSLVIISTLDGRIAALDPENHGKKQWDLDVGSGSLVSSSLSKPEVFGNKMIIPSLDGALFQWDQDRESMETVPFTVESLLESSYKFGDDVVLVGGKSLTTYGLSAYSGKVRYICSALGCRQWDSDEMEQEEDILLLQRTQKTVRAVGPRSGNEKWNFSVGHFELRYIPDMETRAGFIESTFKPNENTEESKIISDVEEQEAAIMDIVIKVSVADWKVMAFSKKGGHLEWEYQFCTPIASAWLLKDGKVIPISLFDDTSYTSNDDVLEDEEDIVEAARGATENSVYLGMYRGQLYLQSSVRISEKFPSSPKALESVTNENAIIPLPTIKWKPLIHSPSRTPVLVGSDEFDKCLSNDKFSHEEYSNGALSILQYPYDNGYYLPYYKRERNKRSTQITVRFLDNPHYNKNIRKKDPVLLLHWWKEIVATILFCIIATTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN
sig_peptide: 1..30 inference: protein motif:SignalP:3.0: note: The cleavage site of the signal peptide has not been experimentally determined. The annotated site is inferred from SignalP prediction. calculated_mol_wt: 3129 peptide sequence: MERAISPGLLVRALLLLLLLLGLAARTVAA mat_peptide: 31..1116 product: eukaryotic translation initiation factor 2-alpha kinase 3 calculated_mol_wt: 122106 peptide sequence: GRARGLPAPTAEAAFGLGAAAAPTSATRVPAAGAVAAAEVTVEDAEALPAAAGEQEPRGPEPDDETELRPRGRSLVIISTLDGRIAALDPENHGKKQWDLDVGSGSLVSSSLSKPEVFGNKMIIPSLDGALFQWDQDRESMETVPFTVESLLESSYKFGDDVVLVGGKSLTTYGLSAYSGKVRYICSALGCRQWDSDEMEQEEDILLLQRTQKTVRAVGPRSGNEKWNFSVGHFELRYIPDMETRAGFIESTFKPNENTEESKIISDVEEQEAAIMDIVIKVSVADWKVMAFSKKGGHLEWEYQFCTPIASAWLLKDGKVIPISLFDDTSYTSNDDVLEDEEDIVEAARGATENSVYLGMYRGQLYLQSSVRISEKFPSSPKALESVTNENAIIPLPTIKWKPLIHSPSRTPVLVGSDEFDKCLSNDKFSHEEYSNGALSILQYPYDNGYYLPYYKRERNKRSTQITVRFLDNPHYNKNIRKKDPVLLLHWWKEIVATILFCIIATTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN

Gene Information

Entrez Gene ID
9451
Gene Name
eukaryotic translation initiation factor 2-alpha kinase 3
Gene Symbol
EIF2AK3
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0004674 IEA:UniProtKB-KW F protein serine/threonine kinase activity
GO:0003743 IEA:UniProtKB-KW F translation initiation factor activity

KEGG Pathway Links

KEGG Pathway ID Description
hsa05169 Epstein-Barr virus infection
hsa05168 Herpes simplex infection
hsa05164 Influenza A
hsa04932 Non-alcoholic fatty liver disease (NAFLD)

Domain Information

InterPro Annotations

Accession Description
IPR000719 Protein kinase domain
IPR017441 Protein kinase, ATP binding site
IPR011009 Protein kinase-like domain
IPR011047 Quinonprotein alcohol dehydrogenase-like superfamily
IPR008271 Serine/threonine-protein kinase, active site

UniProt Annotations

Entry Information

Gene Name
eukaryotic translation initiation factor 2-alpha kinase 3
Protein Entry
E2AK3_HUMAN
UniProt ID
Q9NZJ5
Species
Human

Identical and Related Proteins

Unique RefSeq proteins for LMP002525 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
134304838 RefSeq NP_004827 1116 eukaryotic translation initiation factor 2-alpha kinase 3 precursor

Identical Sequences to LMP002525 proteins

Reference Database Accession Length Protein Name
GI:134304838 SwissProt Q9NZJ5.3 1116 RecName: Full=Eukaryotic translation initiation factor 2-alpha kinase 3; AltName: Full=PRKR-like endoplasmic reticulum kinase; AltName: Full=Pancreatic eIF2-alpha kinase; Short=HsPEK; Flags: Precursor [Homo sapiens]

Related Sequences to LMP002525 proteins

Reference Database Accession Length Protein Name
GI:134304838 DBBJ BAG37696.1 1115 unnamed protein product [Homo sapiens]
GI:134304838 EMBL CAD19334.1 1115 unnamed protein product [Homo sapiens]
GI:134304838 GenBank AAF91480.1 1115 initiation factor 2-alpha kinase 3 [Homo sapiens]
GI:134304838 GenBank AAI26355.1 1116 Eukaryotic translation initiation factor 2-alpha kinase 3 [Homo sapiens]
GI:134304838 GenBank AAI26357.1 1115 Eukaryotic translation initiation factor 2-alpha kinase 3 [Homo sapiens]
GI:134304838 GenBank AHD76529.1 1116 Sequence 20323 from patent US 8586006