Gene/Proteome Database (LMPD)
LMPD ID
LMP002620
Gene ID
Species
Homo sapiens (Human)
Gene Name
retinol binding protein 2, cellular
Gene Symbol
Synonyms
CRABP-II; CRBP2; CRBPII; RBPC2
Alternate Names
retinol-binding protein 2; CRBP-II; cellular retinol-binding protein II; retinol-binding protein 2, cellular
Chromosome
3
Map Location
3q23
Summary
RBP2 is an abundant protein present in the small intestinal epithelium. It is thought to participate in the uptake and/or intracellular metabolism of vitamin A. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. RBP2 may also modulate the supply of retinoic acid to the nuclei of endometrial cells during the menstrual cycle. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
Gene Information
Entrez Gene ID
Gene Name
retinol binding protein 2, cellular
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005829 | TAS:Reactome | C | cytosol |
| GO:0016918 | IEA:UniProtKB-KW | F | retinal binding |
| GO:0005501 | TAS:ProtInc | F | retinoid binding |
| GO:0019841 | IEA:UniProtKB-KW | F | retinol binding |
| GO:0005215 | IEA:InterPro | F | transporter activity |
| GO:0008544 | TAS:ProtInc | P | epidermis development |
| GO:0007603 | TAS:Reactome | P | phototransduction, visible light |
| GO:0001523 | TAS:Reactome | P | retinoid metabolic process |
| GO:0006776 | TAS:ProtInc | P | vitamin A metabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa04977 | Vitamin digestion and absorption |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_24968 | Retinoid metabolism and transport |
| REACT_160125 | Visual phototransduction |
Domain Information
UniProt Annotations
Entry Information
Gene Name
retinol binding protein 2, cellular
Protein Entry
RET2_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Domain | Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. |
| Function | Intracellular transport of retinol. |
| Similarity | Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. |
| Subcellular Location | Cytoplasm. |
| Tissue Specificity | Higher expression in adult small intestine and to a much lesser extent in fetal kidney. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002620 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 40354214 | RefSeq | NP_004155 | 134 | retinol-binding protein 2 |
Identical Sequences to LMP002620 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:40354214 | DBBJ | BAI45846.1 | 134 | retinol binding protein 2, cellular, partial [synthetic construct] |
| GI:40354214 | GenBank | ADQ32877.1 | 134 | retinol binding protein 2, cellular, partial [synthetic construct] |
| GI:40354214 | GenBank | AHD78097.1 | 134 | Sequence 25076 from patent US 8586006 |
| GI:40354214 | GenBank | AIC55025.1 | 134 | RBP2, partial [synthetic construct] |
| GI:40354214 | RefSeq | XP_005247750.1 | 134 | PREDICTED: retinol-binding protein 2 isoform X1 [Homo sapiens] |
| GI:40354214 | RefSeq | XP_006713785.1 | 134 | PREDICTED: retinol-binding protein 2 isoform X2 [Homo sapiens] |
Related Sequences to LMP002620 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:40354214 | GenBank | AAC50162.1 | 134 | cellular retinol binding protein II [Homo sapiens] |
| GI:40354214 | GenBank | AAE27635.1 | 134 | Sequence 5 from patent US 5955305 |
| GI:40354214 | GenBank | AAE34442.1 | 134 | Sequence 9 from patent US 5977309 |
| GI:40354214 | PDB | 2RCQ | 141 | Chain A, Crystal Strucure Of Human Apo Cellular Retinol Binding Protein Ii (Crbp-Ii) |
| GI:40354214 | PDB | 2RCT | 141 | Chain A, Crystal Structure Of Human Holo Cellular Retinol-Binding Protein Ii (Crbp-Ii) |
| GI:40354214 | RefSeq | XP_003265352.1 | 134 | PREDICTED: retinol-binding protein 2 [Nomascus leucogenys] |