Gene/Proteome Database (LMPD)
LMPD ID
LMP002622
Gene ID
Species
Homo sapiens (Human)
Gene Name
alkaline ceramidase 2
Gene Symbol
Synonyms
ALKCDase2; ASAH3L
Chromosome
9
Map Location
9p22.1
Summary
The sphingolipid metabolite sphingosine-1-phosphate promotes cell proliferation and survival, whereas its precursor, sphingosine, has the opposite effect. The ceramidase ACER2 hydrolyzes very long chain ceramides to generate sphingosine (Xu et al., 2006 [PubMed 16940153]).[supplied by OMIM, Jul 2010]
Orthologs
Proteins
| alkaline ceramidase 2 | |
|---|---|
| Refseq ID | NP_001010887 |
| Protein GI | 71043498 |
| UniProt ID | Q5QJU3 |
| mRNA ID | NM_001010887 |
| Length | 275 |
| RefSeq Status | VALIDATED |
| MGAPHWWDQLQAGSSEVDWCEDNYTIVPAIAEFYNTISNVLFFILPPICMCLFRQYATCFNSGIYLIWTLLVVVGIGSVYFHATLSFLGQMLDELAVLWVLMCALAMWFPRRYLPKIFRNDRGRFKVVVSVLSAVTTCLAFVKPAINNISLMTLGVPCTALLIAELKRCDNMRVFKLGLFSGLWWTLALFCWISDRAFCELLSSFNFPYLHCMWHILICLAAYLGCVCFAYFDAASEIPEQGPVIKFWPNEKWAFIGVPYVSLLCANKKSSVKIT | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0016021 | IEA:InterPro | C | integral component of membrane |
| GO:0016811 | IEA:InterPro | F | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| GO:0006672 | IEA:InterPro | P | ceramide metabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa00600 | Sphingolipid metabolism |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY3DJ-11470 | sphingosine and sphingosine-1-phosphate metabolism |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_115810 | Sphingolipid de novo biosynthesis |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR008901 | Ceramidase |
UniProt Annotations
Entry Information
Identical and Related Proteins
Unique RefSeq proteins for LMP002622 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 71043498 | RefSeq | NP_001010887 | 275 | alkaline ceramidase 2 |
Identical Sequences to LMP002622 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:71043498 | GenBank | AHD71244.1 | 275 | Sequence 5938 from patent US 8586006 |
| GI:71043498 | RefSeq | XP_520508.2 | 275 | PREDICTED: alkaline ceramidase 2 isoform X1 [Pan troglodytes] |
| GI:71043498 | RefSeq | XP_003822649.1 | 275 | PREDICTED: alkaline ceramidase 2 isoform X1 [Pan paniscus] |
| GI:71043498 | SwissProt | Q5QJU3.2 | 275 | RecName: Full=Alkaline ceramidase 2; Short=AlkCDase 2; Short=Alkaline CDase 2; Short=haCER2; AltName: Full=Acylsphingosine deacylase 3-like; AltName: Full=N-acylsphingosine amidohydrolase 3-like [Homo sapiens] |
Related Sequences to LMP002622 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:71043498 | DBBJ | BAG53917.1 | 275 | unnamed protein product [Homo sapiens] |
| GI:71043498 | GenBank | AAQ85132.1 | 275 | alkaline ceramidase 2 [Homo sapiens] |
| GI:71043498 | GenBank | EAW58634.1 | 345 | N-acylsphingosine amidohydrolase 3-like, partial [Homo sapiens] |
| GI:71043498 | RefSeq | XP_002819810.1 | 275 | PREDICTED: alkaline ceramidase 2 [Pongo abelii] |
| GI:71043498 | RefSeq | XP_007967321.1 | 275 | PREDICTED: alkaline ceramidase 2 isoform X1 [Chlorocebus sabaeus] |
| GI:71043498 | RefSeq | XP_010364011.1 | 275 | PREDICTED: alkaline ceramidase 2 [Rhinopithecus roxellana] |