Gene/Proteome Database (LMPD)

LMPD ID
LMP002662
Gene ID
76500
Species
Mus musculus (Mouse)
Gene Name
inositol hexaphosphate kinase 2
Gene Symbol
Ip6k2
Synonyms
1500005N04Rik; AW050208; Ihpk2
Alternate Names
inositol hexakisphosphate kinase 2; piUS; insP6 kinase 2; p(i)-uptake stimulator
Chromosome
9
Map Location
9 F2|9
EC Number
2.7.4.21

Proteins

inositol hexakisphosphate kinase 2
Refseq ID NP_083910
Protein GI 225903432
UniProt ID Q80V72
mRNA ID NM_029634
Length 448
RefSeq Status VALIDATED
MSPAFRTMDVEPRTKGILLEPFVHQVGGHSCVLRFNETTLCKPLVPREHQFYETLPAEMRRFTPQYKAVLIFVRCADEFGASGNIETKEQGVVSVRFEEDEDRNLCLIAYPLKGDHGTVDIVDNSDCEPKSKLLRWTNKKHHALETEKNPKDWVRQHRKEEKMKSHKLEEEFEWLKKSEVLYYSVEKKGNVSSQLKHYNPWSMKCHQQQLQRMKENAKHRNQYKFILLENLTSRYEVPCVLDLKMGTRQHGDDASEEKAANQIRKCQQSTSAVIGVRVCGMQVYQAGTGQLMFMNKYHGRKLSVQGFKEALFQFFHNGRYLRRELLGPVLKKLTELKAVLERQESYRFYSSSLLVIYDGKEWPEVTLDSDAEDLEDLSEESADESAGAYAYKPIGASSVDVRMIDFAHTTCRLYGEDSVVHEGQDAGYIFGLQSLIDIVTEISEESGE

Gene Information

Entrez Gene ID
76500
Gene Name
inositol hexaphosphate kinase 2
Gene Symbol
Ip6k2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0045111 IEA:Ensembl C intermediate filament cytoskeleton
GO:0005634 IDA:UniProtKB C nucleus
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0052723 IEA:UniProtKB-EC F inositol hexakisphosphate 1-kinase activity
GO:0052724 IEA:UniProtKB-EC F inositol hexakisphosphate 3-kinase activity
GO:0000832 IEA:UniProtKB-EC F inositol hexakisphosphate 5-kinase activity
GO:0008440 IEA:InterPro F inositol-1,4,5-trisphosphate 3-kinase activity
GO:0030308 IEA:Ensembl P negative regulation of cell growth
GO:0006817 IEA:Ensembl P phosphate ion transport
GO:0046854 IEA:Ensembl P phosphatidylinositol phosphorylation
GO:0043065 IEA:Ensembl P positive regulation of apoptotic process

REACTOME Pathway Links

REACTOME Pathway ID Description
5894026 Inositol phosphate metabolism
5892760 Metabolism
5894028 Synthesis of IPs in the nucleus

Domain Information

InterPro Annotations

Accession Description
IPR005522 Inositol polyphosphate kinase

UniProt Annotations

Entry Information

Gene Name
inositol hexaphosphate kinase 2
Protein Entry
IP6K2_MOUSE
UniProt ID
Q80V72
Species
Mouse

Comments

Comment Type Description
Catalytic Activity ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6- pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.
Catalytic Activity ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
Function Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Was first identified because of its ability to stimulate Na(+)-dependent phosphate cotransport (By similarity). {ECO:0000250}.
Similarity Belongs to the inositol phosphokinase (IPK) family. {ECO:0000305}.
Subcellular Location Nucleus {ECO:0000250}.
Tissue Specificity Highly expressed in brain and lung, and at slightly lower levels in liver, kidney and testis. {ECO:0000269|PubMed:10574768}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002662 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
225903432 RefSeq NP_083910 448 inositol hexakisphosphate kinase 2

Identical Sequences to LMP002662 proteins

Reference Database Accession Length Protein Name
GI:225903432 RefSeq XP_006511913.1 448 PREDICTED: inositol hexakisphosphate kinase 2 isoform X1 [Mus musculus]
GI:225903432 RefSeq XP_006511914.1 448 PREDICTED: inositol hexakisphosphate kinase 2 isoform X2 [Mus musculus]
GI:225903432 SwissProt Q80V72.2 448 RecName: Full=Inositol hexakisphosphate kinase 2; Short=InsP6 kinase 2; AltName: Full=P(i)-uptake stimulator; Short=PiUS [Mus musculus]

Related Sequences to LMP002662 proteins

Reference Database Accession Length Protein Name
GI:225903432 GenBank AAH39922.1 448 Inositol hexaphosphate kinase 2 [Mus musculus]
GI:225903432 RefSeq XP_003504281.1 448 PREDICTED: inositol hexakisphosphate kinase 2 isoform X1 [Cricetulus griseus]
GI:225903432 RefSeq XP_005075012.1 448 PREDICTED: inositol hexakisphosphate kinase 2 isoform X1 [Mesocricetus auratus]
GI:225903432 RefSeq XP_006978359.1 448 PREDICTED: inositol hexakisphosphate kinase 2 isoform X2 [Peromyscus maniculatus bairdii]
GI:225903432 RefSeq XP_007632963.1 448 PREDICTED: inositol hexakisphosphate kinase 2 isoform X1 [Cricetulus griseus]
GI:225903432 RefSeq XP_008764788.1 448 PREDICTED: inositol hexakisphosphate kinase 2 isoform X3 [Rattus norvegicus]