Gene/Proteome Database (LMPD)

LMPD ID
LMP002715
Gene ID
10423
Species
Homo sapiens (Human)
Gene Name
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Gene Symbol
CDIPT
Synonyms
PIS; PIS1
Chromosome
16
Map Location
16p11.2
Summary
Phosphatidylinositol breakdown products are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. Two enzymes, CDP-diacylglycerol synthase and phosphatidylinositol synthase, are involved in the biosynthesis of phosphatidylinositol. Phosphatidylinositol synthase, a member of the CDP-alcohol phosphatidyl transferase class-I family, is an integral membrane protein found on the cytoplasmic side of the endoplasmic reticulum and the Golgi apparatus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Orthologs
View orthologs and multiple alignments for CDIPT

Proteins

CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform 1
Refseq ID NP_006310
Protein GI 5453906
UniProt ID O14735
mRNA ID NM_006319
Length 213
RefSeq Status REVIEWED
MPDENIFLFVPNLIGYARIVFAIISFYFMPCCPLTASSFYLLSGLLDAFDGHAARALNQGTRFGAMLDMLTDRCSTMCLLVNLALLYPGATLFFQISMSLDVASHWLHLHSSVVRGSESHKMIDLSGNPVLRIYYTSRPALFTLCAGNELFYCLLYLFHFSEGPLVGSVGLFRMGLWVTAPIALLKSLISVIHLITAARNMAALDAADRAKKK
CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform 2
Refseq ID NP_001273514
Protein GI 557440904
UniProt ID O14735
mRNA ID NM_001286585
Length 168
RefSeq Status REVIEWED
MPDENIFLFVPNLIGTRFGAMLDMLTDRCSTMCLLVNLALLYPGATLFFQISMSLDVASHWLHLHSSVVRGSESHKMIDLSGNPVLRIYYTSRPALFTLCAGNELFYCLLYLFHFSEGPLVGSVGLFRMGLWVTAPIALLKSLISVIHLITAARNMAALDAADRAKKK
CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform 3
Refseq ID NP_001273515
Protein GI 557440906
UniProt ID A8K3L7
mRNA ID NM_001286586
Length 148
RefSeq Status REVIEWED
MLDMLTDRCSTMCLLVNLALLYPGATLFFQISMSLDVASHWLHLHSSVVRGSESHKMIDLSGNPVLRIYYTSRPALFTLCAGNELFYCLLYLFHFSEGPLVGSVGLFRMGLWVTAPIALLKSLISVIHLITAARNMAALDAADRAKKK

Gene Information

Entrez Gene ID
10423
Gene Name
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Gene Symbol
CDIPT
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016020 IEA:InterPro C membrane
GO:0003881 IEA:Ensembl F CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity
GO:0043178 IEA:Ensembl F alcohol binding
GO:0030246 IEA:Ensembl F carbohydrate binding
GO:0019992 IEA:Ensembl F diacylglycerol binding
GO:0030145 IEA:Ensembl F manganese ion binding
GO:0046341 IEA:Ensembl P CDP-diacylglycerol metabolic process
GO:0006661 IEA:Ensembl P phosphatidylinositol biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00564 Glycerophospholipid metabolism
hsa00562 Inositol phosphate metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6352 3-phosphoinositide biosynthesis
PWY-6351 D-myo-inositol (1,4,5)-trisphosphate biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR000462 CDP-alcohol phosphatidyltransferase
IPR014387 CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote

UniProt Annotations

Entry Information

Gene Name
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Protein Entry
A8K3L7_HUMAN
UniProt ID
O14735
Species
Human

Identical and Related Proteins

Unique RefSeq proteins for LMP002715 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
5453906 RefSeq NP_006310 213 CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform 1
557440904 RefSeq NP_001273514 168 CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform 2
557440906 RefSeq NP_001273515 148 CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform 3

Identical Sequences to LMP002715 proteins

Reference Database Accession Length Protein Name
GI:5453906 GenBank JAA01654.1 213 CDP-diacylglycerol--inositol 3-phosphatidyltransferase [Pan troglodytes]
GI:5453906 GenBank JAA20658.1 213 CDP-diacylglycerol--inositol 3-phosphatidyltransferase [Pan troglodytes]
GI:5453906 GenBank JAA22207.1 213 CDP-diacylglycerol--inositol 3-phosphatidyltransferase [Pan troglodytes]
GI:5453906 GenBank JAA33651.1 213 CDP-diacylglycerol--inositol 3-phosphatidyltransferase [Pan troglodytes]
GI:5453906 GenBank AIC50616.1 213 CDIPT, partial [synthetic construct]
GI:5453906 RefSeq XP_003809413.1 213 PREDICTED: CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform X2 [Pan paniscus]
GI:557440906 RefSeq XP_008959844.1 148 PREDICTED: CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform X3 [Pan paniscus]
GI:557440906 RefSeq XP_009428877.1 148 PREDICTED: CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform X3 [Pan troglodytes]

Related Sequences to LMP002715 proteins

Reference Database Accession Length Protein Name
GI:557440906 DBBJ BAF83321.1 213 unnamed protein product [Homo sapiens]
GI:557440904 DBBJ BAG62462.1 168 unnamed protein product [Homo sapiens]
GI:557440906 GenBank AAB94860.1 213 phosphatidylinositol synthase [Homo sapiens]
GI:5453906 GenBank AAP36554.1 214 Homo sapiens CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase), partial [synthetic construct]
GI:557440906 GenBank AAX32113.1 213 CDP-diacylglycerol-inositol 3-phosphatidyltransferase [synthetic construct]
GI:557440906 GenBank AAX32114.1 213 CDP-diacylglycerol-inositol 3-phosphatidyltransferase [synthetic construct]
GI:5453906 GenBank AAX37049.1 214 CDP-diacylglycerol-inositol 3-phosphatidyltransferase, partial [synthetic construct]
GI:5453906 GenBank AAX43736.1 214 CDP-diacylglycerol-inositol 3-phosphatidyltransferase, partial [synthetic construct]
GI:557440906 GenBank EAW79977.1 213 CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase), isoform CRA_a [Homo sapiens]
GI:5453906 GenBank ACM81979.1 287 Sequence 7477 from patent US 6812339
GI:557440906 RefSeq XP_001145226.1 213 PREDICTED: CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform X2 [Pan troglodytes]
GI:557440904 RefSeq XP_003282035.1 168 PREDICTED: CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform 2 [Nomascus leucogenys]
GI:557440904 RefSeq XP_003918745.1 168 PREDICTED: CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform X3 [Papio anubis]
GI:5453906 RefSeq XP_004057507.1 213 PREDICTED: CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform 1 [Gorilla gorilla gorilla]
GI:5453906 RefSeq XP_004057508.1 213 PREDICTED: CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform 2 [Gorilla gorilla gorilla]
GI:557440904 RefSeq XP_006896596.1 168 PREDICTED: CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform X2 [Elephantulus edwardii]
GI:557440904 RefSeq XP_007452812.1 168 PREDICTED: CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform X3 [Lipotes vexillifer]
GI:557440904 RefSeq XP_007987956.1 168 PREDICTED: CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform X2 [Chlorocebus sabaeus]