Gene/Proteome Database (LMPD)

LMPD ID
LMP002725
Gene ID
67758
Species
Mus musculus (Mouse)
Gene Name
arylacetamide deacetylase (esterase)
Gene Symbol
Aadac
Synonyms
5033417E09Rik; AI265437; Aada
Alternate Names
arylacetamide deacetylase
Chromosome
3
Map Location
3 D|3
EC Number
3.1.1.3

Proteins

arylacetamide deacetylase precursor
Refseq ID NP_075872
Protein GI 13184050
UniProt ID Q99PG0
mRNA ID NM_023383
Length 398
RefSeq Status VALIDATED
MGKTISLLISVVLVAYYLYIPLPDAIEEPWKVVWETAFVKIGTDLASFGELLGISHFMETIQLLMSFQEVPPTSDEHVTVMETAFDSVPVRIYIPKRKSMALRRGLFYIHGGGWCLGSAAHFSYDTLSRWTAHKLDAVVVSTDYGLAPKHHFPRQFEDVYRSLRWFLQEDVLEKYGVDPRRVGVSGDSAGGNLAAAVTQQLIQDPDVKIKLKVQALIYPALQALDTNVPSQQEGSHFPVLTRSLMVRFWSEYFTTDRGLEKAMLLNQHVPMESSHLLQFVNWSSLLPERYKKSPVYKNPTPGSSELAQKYPGFIDVKACPLLANDNILHHLPKTYIITCQYDVLRDDGLMYVKRLQNVGVHVTHHHVEDGFHGTFSFPGLKLSERMKNQYLSWLIKNL
sig_peptide: 1..25 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2753 peptide sequence: MGKTISLLISVVLVAYYLYIPLPDA

Gene Information

Entrez Gene ID
67758
Gene Name
arylacetamide deacetylase (esterase)
Gene Symbol
Aadac
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 IDA:UniProtKB C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0019213 ISS:UniProtKB F deacetylase activity
GO:0016298 TAS:MGI F lipase activity
GO:0017171 IDA:UniProtKB F serine hydrolase activity
GO:0004806 IDA:UniProtKB F triglyceride lipase activity
GO:0010898 IDA:UniProtKB P positive regulation of triglyceride catabolic process

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR013094 Alpha/beta hydrolase fold-3
IPR017157 Arylacetamide deacetylase
IPR002168 Lipase, GDXG, active site

UniProt Annotations

Entry Information

Gene Name
arylacetamide deacetylase (esterase)
Protein Entry
AAAD_MOUSE
UniProt ID
Q99PG0
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Triacylglycerol + H(2)O = diacylglycerol + a carboxylate. {ECO:0000269|PubMed:19654421}.
Function Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly (By similarity). Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity. {ECO:0000250, ECO:0000269|PubMed:19654421, ECO:0000269|PubMed:22207054}.
Ptm N-glycosylated. {ECO:0000269|PubMed:19654421}.
Similarity Belongs to the 'GDXG' lipolytic enzyme family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:19654421}; Single-pass type II membrane protein {ECO:0000269|PubMed:19654421}. Microsome membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Tissue Specificity Highest levels in liver with lower levels in jejunum and kidney. {ECO:0000269|PubMed:19654421, ECO:0000269|PubMed:22207054}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002725 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13184050 RefSeq NP_075872 398 arylacetamide deacetylase precursor

Identical Sequences to LMP002725 proteins

Reference Database Accession Length Protein Name
GI:13184050 GenBank AAG60035.1 398 arylacetamide deacetylase [Mus musculus]
GI:13184050 SwissProt Q99PG0.3 398 RecName: Full=Arylacetamide deacetylase [Mus musculus]

Related Sequences to LMP002725 proteins

Reference Database Accession Length Protein Name
GI:13184050 GenBank AAD56394.1 398 arylacetamide deacetylase [Rattus norvegicus]
GI:13184050 GenBank AAH19999.1 398 Arylacetamide deacetylase (esterase) [Mus musculus]
GI:13184050 GenBank AAH54823.1 398 Arylacetamide deacetylase (esterase) [Mus musculus]
GI:13184050 GenBank AAH88143.1 398 Arylacetamide deacetylase (esterase) [Rattus norvegicus]
GI:13184050 GenBank EDL35371.1 404 arylacetamide deacetylase (esterase), isoform CRA_b, partial [Mus musculus]
GI:13184050 GenBank EDM14838.1 398 arylacetamide deacetylase (esterase), isoform CRA_a [Rattus norvegicus]