Gene/Proteome Database (LMPD)

LMPD ID
LMP002749
Gene ID
8703
Species
Homo sapiens (Human)
Gene Name
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3
Gene Symbol
B4GALT3
Synonyms
beta4Gal-T3
Chromosome
1
Map Location
1q21-q23
Summary
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene encodes an enzyme that may be mainly involved in the synthesis of the first N-acetyllactosamine unit of poly-N-acetyllactosamine chains. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2010]
Orthologs
View orthologs and multiple alignments for B4GALT3

Proteins

beta-1,4-galactosyltransferase 3
Refseq ID NP_001186802
Protein GI 315467841
UniProt ID O60512
mRNA ID NM_001199873
Length 393
RefSeq Status REVIEWED
MLRRLLERPCTLALLVGSQLAVMMYLSLGGFRSLSALFGRDQGPTFDYSHPRDVYSNLSHLPGAPGGPPAPQGLPYCPERSPLLVGPVSVSFSPVPSLAEIVERNPRVEPGGRYRPAGCEPRSRTAIIVPHRAREHHLRLLLYHLHPFLQRQQLAYGIYVIHQAGNGTFNRAKLLNVGVREALRDEEWDCLFLHDVDLLPENDHNLYVCDPRGPRHVAVAMNKFGYSLPYPQYFGGVSALTPDQYLKMNGFPNEYWGWGGEDDDIATRVRLAGMKISRPPTSVGHYKMVKHRGDKGNEENPHRFDLLVRTQNSWTQDGMNSLTYQLLARELGPLYTNITADIGTDPRGPRAPSGPRYPPGSSQAFRQEMLQRRPPARPGPLSTANHTALRGSH
beta-1,4-galactosyltransferase 3
Refseq ID NP_001186803
Protein GI 315467844
UniProt ID O60512
mRNA ID NM_001199874
Length 393
RefSeq Status REVIEWED
Protein sequence is identical to GI:315467841 (mRNA isoform)
beta-1,4-galactosyltransferase 3
Refseq ID NP_003770
Protein GI 4502349
UniProt ID O60512
mRNA ID NM_003779
Length 393
RefSeq Status REVIEWED
Protein sequence is identical to GI:315467841 (mRNA isoform)

Gene Information

Entrez Gene ID
8703
Gene Name
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3
Gene Symbol
B4GALT3
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016757 IEA:InterPro F transferase activity, transferring glycosyl groups
GO:0005975 IEA:InterPro P carbohydrate metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00533 Glycosaminoglycan biosynthesis - keratan sulfate
hsa00510 N-Glycan biosynthesis
hsa00514 Other types of O-glycan biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_121120 Keratan sulfate biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR003859 Beta-1,4-galactosyltransferase
IPR027995 Galactosyltransferase, N-terminal
IPR029044 Nucleotide-diphospho-sugar transferases

UniProt Annotations

Entry Information

Gene Name
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3
Protein Entry
B4GT3_HUMAN
UniProt ID
O60512
Species
Human

Identical and Related Proteins

Unique RefSeq proteins for LMP002749 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
315467841 RefSeq NP_001186802 393 beta-1,4-galactosyltransferase 3

Identical Sequences to LMP002749 proteins

Reference Database Accession Length Protein Name
GI:315467841 GenBank AEP61207.1 393 Sequence 301 from patent US 8026065
GI:315467841 GenBank AFO05702.1 393 Sequence 340 from patent US 8216786
GI:315467841 GenBank AIC50183.1 393 B4GALT3, partial [synthetic construct]
GI:315467841 GenBank AIC55460.1 393 B4GALT3, partial [synthetic construct]
GI:315467841 RefSeq XP_005245623.1 393 PREDICTED: beta-1,4-galactosyltransferase 3 isoform X1 [Homo sapiens]
GI:315467841 RefSeq XP_006711663.1 393 PREDICTED: beta-1,4-galactosyltransferase 3 isoform X2 [Homo sapiens]

Related Sequences to LMP002749 proteins

Reference Database Accession Length Protein Name
GI:315467841 GenBank ACM83248.1 481 Sequence 8746 from patent US 6812339
GI:315467841 RefSeq XP_008962477.1 393 PREDICTED: beta-1,4-galactosyltransferase 3 [Pan paniscus]
GI:315467841 RefSeq XP_008962478.1 393 PREDICTED: beta-1,4-galactosyltransferase 3 [Pan paniscus]
GI:315467841 RefSeq XP_008962479.1 393 PREDICTED: beta-1,4-galactosyltransferase 3 [Pan paniscus]
GI:315467841 RefSeq XP_008962480.1 393 PREDICTED: beta-1,4-galactosyltransferase 3 [Pan paniscus]
GI:315467841 RefSeq XP_008962481.1 393 PREDICTED: beta-1,4-galactosyltransferase 3 [Pan paniscus]