Gene/Proteome Database (LMPD)
LMPD ID
LMP002777
Gene ID
Species
Homo sapiens (Human)
Gene Name
aldo-keto reductase family 1, member A1 (aldehyde reductase)
Gene Symbol
Synonyms
ALDR1; ALR; ARM; DD3; HEL-S-6
Alternate Names
alcohol dehydrogenase [NADP(+)]; HEL-S-165mP; aldehyde reductase; alcohol dehydrogenase; dihydrodiol dehydrogenase 3; epididymis secretory protein Li 6; aldo-keto reductase family 1 member A1; epididymis secretory sperm binding protein Li 165mP
Chromosome
1
Map Location
1p33-p32
EC Number
1.1.1.2
Summary
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. [provided by RefSeq, Jan 2011]
Orthologs
Proteins
| alcohol dehydrogenase [NADP(+)] | |
|---|---|
| Refseq ID | NP_697021 |
| Protein GI | 24497577 |
| UniProt ID | P14550 |
| mRNA ID | NM_153326 |
| Length | 325 |
| RefSeq Status | REVIEWED |
| MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIVPMLTVDGKRVPRDAGHPLYPFNDPY | |
| alcohol dehydrogenase [NADP(+)] | |
|---|---|
| Refseq ID | NP_001189342 |
| Protein GI | 320202988 |
| UniProt ID | P14550 |
| mRNA ID | NM_001202413 |
| Length | 325 |
| RefSeq Status | REVIEWED |
| Protein sequence is identical to GI:24497577 (mRNA isoform) | |
| alcohol dehydrogenase [NADP(+)] | |
|---|---|
| Refseq ID | NP_001189343 |
| Protein GI | 320202986 |
| UniProt ID | P14550 |
| mRNA ID | NM_001202414 |
| Length | 325 |
| RefSeq Status | REVIEWED |
| Protein sequence is identical to GI:24497577 (mRNA isoform) | |
Gene Information
Entrez Gene ID
Gene Name
aldo-keto reductase family 1, member A1 (aldehyde reductase)
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0016324 | IEA:Ensembl | C | apical plasma membrane |
| GO:0005829 | IEA:Ensembl | C | cytosol |
| GO:0005615 | IDA:UniProt | C | extracellular space |
| GO:0070062 | IDA:UniProtKB | C | extracellular vesicular exosome |
| GO:0047939 | IEA:Ensembl | F | L-glucuronate reductase activity |
| GO:0004032 | TAS:ProtInc | F | alditol:NADP+ 1-oxidoreductase activity |
| GO:0009055 | TAS:UniProtKB | F | electron carrier activity |
| GO:0042840 | IEA:Ensembl | P | D-glucuronate catabolic process |
| GO:0019853 | IEA:Ensembl | P | L-ascorbic acid biosynthetic process |
| GO:0046185 | IEA:Ensembl | P | aldehyde catabolic process |
| GO:0006081 | TAS:ProtInc | P | cellular aldehyde metabolic process |
| GO:0006006 | TAS:ProtInc | P | glucose metabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa01220 | Degradation of aromatic compounds |
| hsa00010 | Glycolysis / Gluconeogenesis |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY-6307 | tryptophan degradation X (mammalian, via tryptamine) |
Domain Information
UniProt Annotations
Entry Information
Gene Name
aldo-keto reductase family 1, member A1 (aldehyde reductase)
Protein Entry
AK1A1_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | An alcohol + NADP(+) = an aldehyde + NADPH. |
| Function | Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4- nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D- glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). {ECO |
| Similarity | Belongs to the aldo/keto reductase family. |
| Subunit | Monomer. |
| Tissue Specificity | Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea, stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002777 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 24497577 | RefSeq | NP_697021 | 325 | alcohol dehydrogenase [NADP(+)] |
Identical Sequences to LMP002777 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:24497577 | GenBank | AIC50592.1 | 325 | AKR1A1, partial [synthetic construct] |
| GI:24497577 | GenBank | AIC55756.1 | 325 | AKR1A1, partial [synthetic construct] |
| GI:24497577 | RefSeq | XP_003812814.1 | 325 | PREDICTED: alcohol dehydrogenase [NADP(+)] [Pan paniscus] |
| GI:24497577 | RefSeq | XP_003812815.1 | 325 | PREDICTED: alcohol dehydrogenase [NADP(+)] [Pan paniscus] |
| GI:24497577 | RefSeq | XP_008963485.1 | 325 | PREDICTED: alcohol dehydrogenase [NADP(+)] [Pan paniscus] |
| GI:24497577 | RefSeq | XP_008963486.1 | 325 | PREDICTED: alcohol dehydrogenase [NADP(+)] [Pan paniscus] |
Related Sequences to LMP002777 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:24497577 | GenBank | AAP36383.1 | 326 | Homo sapiens aldo-keto reductase family 1, member A1 (aldehyde reductase), partial [synthetic construct] |
| GI:24497577 | GenBank | AAX43811.1 | 326 | aldo-keto reductase family 1 member A1, partial [synthetic construct] |
| GI:24497577 | GenBank | JAA06087.1 | 325 | aldo-keto reductase family 1, member A1 (aldehyde reductase) [Pan troglodytes] |
| GI:24497577 | RefSeq | XP_001157276.2 | 325 | PREDICTED: alcohol dehydrogenase [NADP(+)] [Pan troglodytes] |
| GI:24497577 | RefSeq | XP_009454825.1 | 325 | PREDICTED: alcohol dehydrogenase [NADP(+)] [Pan troglodytes] |
| GI:24497577 | RefSeq | XP_009454836.1 | 325 | PREDICTED: alcohol dehydrogenase [NADP(+)] [Pan troglodytes] |