Gene/Proteome Database (LMPD)

LMPD ID
LMP002839
Gene ID
19017
Species
Mus musculus (Mouse)
Gene Name
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
Gene Symbol
Ppargc1a
Synonyms
A830037N07Rik; ENSMUSG00000079510; Gm11133; PGC-1; PGC-1v; Pgc-1alpha; Pgc1; Pgco1; Ppargc1
Alternate Names
peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PGC-1-alpha; Pgc-1alphaa; PPARGC-1-alpha; PPAR Gamma Coactivator-1; PPAR-gamma coactivator 1-alpha; PPAR gamma coactivator variant form; peroxisome proliferator-activated receptor gamma coactivator-1 alpha
Chromosome
5
Map Location
5 C1|5

Proteins

peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Refseq ID NP_032930
Protein GI 6679433
UniProt ID O70343
mRNA ID NM_008904
Length 797
RefSeq Status VALIDATED
MAWDMCSQDSVWSDIECAALVGEDQPLCPDLPELDLSELDVNDLDTDSFLGGLKWCSDQSEIISNQYNNEPANIFEKIDEENEANLLAVLTETLDSLPVDEDGLPSFDALTDGAVTTDNEASPSSMPDGTPPPQEAEEPSLLKKLLLAPANTQLSYNECSGLSTQNHAANHTHRIRTNPAIVKTENSWSNKAKSICQQQKPQRRPCSELLKYLTTNDDPPHTKPTENRNSSRDKCASKKKSHTQPQSQHAQAKPTTLSLPLTPESPNDPKGSPFENKTIERTLSVELSGTAGLTPPTTPPHKANQDNPFKASPKLKPSCKTVVPPPTKRARYSECSGTQGSHSTKKGPEQSELYAQLSKSSGLSRGHEERKTKRPSLRLFGDHDYCQSLNSKTDILINISQELQDSRQLDFKDASCDWQGHICSSTDSGQCYLRETLEASKQVSPCSTRKQLQDQEIRAELNKHFGHPCQAVFDDKSDKTSELRDGDFSNEQFSKLPVFINSGLAMDGLFDDSEDESDKLSYPWDGTQPYSLFDVSPSCSSFNSPCRDSVSPPKSLFSQRPQRMRSRSRSFSRHRSCSRSPYSRSRSRSPGSRSSSRSCYYYESSHYRHRTHRNSPLYVRSRSRSPYSRRPRYDSYEAYEHERLKRDEYRKEHEKRESERAKQRERQKQKAIEERRVIYVGKIRPDTTRTELRDRFEVFGEIEECTVNLRDDGDSYGFITYRYTCDAFAALENGYTLRRSNETDFELYFCGRKQFFKSNYADLDTNSDDFDPASTKSKYDSLDFDSLLKEAQRSLRR

Gene Information

Entrez Gene ID
19017
Gene Name
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
Gene Symbol
Ppargc1a
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IEA:Ensembl C cytosol
GO:0005654 TAS:Reactome C nucleoplasm
GO:0005634 IDA:MGI C nucleus
GO:0003677 IDA:MGI F DNA binding
GO:0003723 IEA:UniProtKB-KW F RNA binding
GO:0031490 IDA:MGI F chromatin DNA binding
GO:0030374 IEA:Ensembl F ligand-dependent nuclear receptor transcription coactivator activity
GO:0000166 IEA:InterPro F nucleotide binding
GO:0043565 ISS:UniProtKB F sequence-specific DNA binding
GO:0003713 IDA:UniProtKB F transcription coactivator activity
GO:0008134 IPI:BHF-UCL F transcription factor binding
GO:0008209 IEA:Ensembl P androgen metabolic process
GO:0071398 IEA:Ensembl P cellular response to fatty acid
GO:0071456 IEA:Ensembl P cellular response to hypoxia
GO:0071250 IEA:Ensembl P cellular response to nitrite
GO:0034599 IMP:MGI P cellular response to oxidative stress
GO:0097067 IEA:Ensembl P cellular response to thyroid hormone stimulus
GO:0071356 IEA:Ensembl P cellular response to tumor necrosis factor
GO:0032922 IDA:UniProtKB P circadian regulation of gene expression
GO:0051552 IEA:Ensembl P flavone metabolic process
GO:0006012 IEA:Ensembl P galactose metabolic process
GO:0007005 IEA:Ensembl P mitochondrion organization
GO:0045820 IEA:Ensembl P negative regulation of glycolytic process
GO:0043524 IMP:MGI P negative regulation of neuron apoptotic process
GO:1901215 ISS:UniProtKB P negative regulation of neuron death
GO:2000272 IEA:Ensembl P negative regulation of receptor activity
GO:0070997 IEA:Ensembl P neuron death
GO:2001171 IMP:UniProtKB P positive regulation of ATP biosynthetic process
GO:1901857 IMP:UniProtKB P positive regulation of cellular respiration
GO:2000507 IMP:UniProtKB P positive regulation of energy homeostasis
GO:0046321 IEA:Ensembl P positive regulation of fatty acid oxidation
GO:1901860 IMP:UniProtKB P positive regulation of mitochondrial DNA metabolic process
GO:0010822 IMP:UniProtKB P positive regulation of mitochondrion organization
GO:1901863 IMP:UniProtKB P positive regulation of muscle tissue development
GO:0051091 IDA:BHF-UCL P positive regulation of sequence-specific DNA binding transcription factor activity
GO:0048661 IEA:Ensembl P positive regulation of smooth muscle cell proliferation
GO:0045944 IMP:BHF-UCL P positive regulation of transcription from RNA polymerase II promoter
GO:0045893 IDA:MGI P positive regulation of transcription, DNA-templated
GO:2000310 IEA:Ensembl P regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:0042752 IDA:UniProtKB P regulation of circadian rhythm
GO:0006355 ISS:UniProtKB P regulation of transcription, DNA-templated
GO:0022904 IDA:MGI P respiratory electron transport chain
GO:0009409 IEA:Ensembl P response to cold
GO:0071871 IEA:Ensembl P response to epinephrine
GO:0043201 IEA:Ensembl P response to leucine
GO:0014850 IMP:BHF-UCL P response to muscle activity
GO:0071873 IEA:Ensembl P response to norepinephrine
GO:0042594 IEA:Ensembl P response to starvation
GO:0036273 IEA:Ensembl P response to statin
GO:0006351 IEA:UniProtKB-KW P transcription, DNA-templated

KEGG Pathway Links

KEGG Pathway ID Description
mmu04152 AMPK signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR012677 Nucleotide-binding alpha-beta plait domain
IPR000504 RNA recognition motif domain

UniProt Annotations

Entry Information

Gene Name
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
Protein Entry
PRGC1_MOUSE
UniProt ID
O70343
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative promoter usage, Alternative splicing; Named isoforms=4; Name=1; Synonyms=PGC-1a1; IsoId=O70343-1; Sequence=Displayed; Name=2; Synonyms=PGC-1a2; IsoId=O70343-2; Sequence=VSP_053275, VSP_053277, VSP_053278, VSP_053280; Note=Produced by alternative promoter usage and alternative splicing.; Name=3; Synonyms=PGC-1a3; IsoId=O70343-3; Sequence=VSP_053276, VSP_053277, VSP_053278, VSP_053280; Note=Produced by alternative promoter usage and alternative splicing.; Name=4; Synonyms=PGC-1a4; IsoId=O70343-4; Sequence=VSP_053275, VSP_053279, VSP_053281; Note=Produced by alternative promoter usage and alternative splicing.;
Disruption Phenotype Mice show abnormal diurnal rhythms of activity, body temperature and metabolic rate. {ECO:0000269|PubMed:17476214}.
Function Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK. Isoform 4 specifically activates the expression of IGF1 and suppresses myostatin expression in skeletal muscle leading to muscle fiber hypertrophy. {ECO:0000269|PubMed:15744310, ECO:0000269|PubMed:17476214, ECO:0000269|PubMed:23217713, ECO:0000269|PubMed:9529258}.
Induction Dramatically induced in brown adipose tissue and skeletal muscle by exposure of animals to cold. Up-regulated in brown adipose tissue of obese leptin-deficient (ob/ob) and leptin- unresponsive (db/db) mice. Leptin is required for normal basal and cold-stimulated expression in brown adipose tissue and hyperleptinemia rapidly up-regulates its expression. Induced in muscle by exercise. Oscillates diurnally in liver and skeletal muscle. {ECO:0000269|PubMed:11108270, ECO:0000269|PubMed:17476214, ECO:0000269|PubMed:22237023, ECO:0000269|PubMed:23217713, ECO:0000269|PubMed:9529258}.
Interaction Q6PB66:Lrpprc; NbExp=2; IntAct=EBI-1371053, EBI-1371262; Q923E4:Sirt1; NbExp=6; IntAct=EBI-1371053, EBI-1802585;
Ptm Heavily acetylated by GCN5 and biologically inactive under conditions of high nutrients. Deacetylated by SIRT1 in low nutrients/high NAD conditions. {ECO:0000269|PubMed:15744310}.
Ptm Phosphorylation by AMPK in skeletal muscle increases activation of its own promoter. Phosphorylated by CLK2. {ECO:0000269|PubMed:17609368, ECO:0000269|PubMed:20074525}.
Ptm Ubiquitinated. Ubiquitination by RNF34 induces proteasomal degradation. {ECO:0000250|UniProtKB:Q9UBK2}.
Similarity Contains 1 RRM (RNA recognition motif) domain. {ECO:0000255|PROSITE-ProRule:PRU00176}.
Subcellular Location Nucleus. Nucleus, PML body.
Subunit Homooligomer (By similarity). Interacts with MYBBP1A; inhibits MYBBP1A transcriptional activation. Interacts with PRDM16, LPIN1 and PML. Interacts (via LXXLL motif) with RORA and RORC (via AF-2 motif); activates RORA and RORC transcriptional activation. Interacts with LRPPRC (By similarity). Interacts with RNF34 (via RING-type zinc finger) (By similarity). {ECO:0000250|UniProtKB:Q9UBK2, ECO:0000269|PubMed:14744933, ECO:0000269|PubMed:16950137, ECO:0000269|PubMed:17476214, ECO:0000269|PubMed:17618855, ECO:0000269|PubMed:18483224, ECO:0000269|PubMed:22886304}.
Tissue Specificity White quadriceps and red tibialis anterior (TA) muscles, liver, kidney and brown adipose tissue (at protein level). Skeletal muscle, brown adipose tissue, heart, kidney and brain. {ECO:0000269|PubMed:17476214, ECO:0000269|PubMed:23217713, ECO:0000269|PubMed:9529258}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002839 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6679433 RefSeq NP_032930 797 peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Identical Sequences to LMP002839 proteins

Reference Database Accession Length Protein Name
GI:6679433 EMBL CAK22377.1 797 unnamed protein product [Mus musculus]
GI:6679433 GenBank EDL37647.1 797 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha, isoform CRA_a [Mus musculus]
GI:6679433 GenBank ABU39464.1 797 Sequence 2 from patent US 7250283
GI:6679433 GenBank ACE26972.1 797 Sequence 2 from patent US 7371529
GI:6679433 GenBank ADF24839.1 797 Sequence 4 from patent US 7691578
GI:6679433 GenBank AEH98541.1 797 Sequence 46 from patent US 7947652

Related Sequences to LMP002839 proteins

Reference Database Accession Length Protein Name
GI:6679433 GenBank AAH66868.1 797 Peroxisome proliferative activated receptor, gamma, coactivator 1 alpha [Mus musculus]
GI:6679433 RefSeq XP_006503837.1 810 PREDICTED: peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [Mus musculus]
GI:6679433 RefSeq XP_006503838.1 793 PREDICTED: peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X2 [Mus musculus]
GI:6679433 RefSeq XP_006503839.1 787 PREDICTED: peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X3 [Mus musculus]
GI:6679433 RefSeq XP_006503840.1 784 PREDICTED: peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X4 [Mus musculus]
GI:6679433 RefSeq XP_006503841.1 782 PREDICTED: peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X5 [Mus musculus]