Gene/Proteome Database (LMPD)

LMPD ID
LMP002864
Gene ID
19222
Species
Mus musculus (Mouse)
Gene Name
prostaglandin I receptor (IP)
Gene Symbol
Ptgir
Synonyms
IP; PGI2
Alternate Names
prostacyclin receptor; PGI receptor; PGI2 receptor; prostanoid IP receptor; prostaglandin I2 receptor
Chromosome
7
Map Location
7 A2|7 9.15 cM

Proteins

prostacyclin receptor
Refseq ID NP_032993
Protein GI 163965438
UniProt ID P43252
mRNA ID NM_008967
Length 415
RefSeq Status VALIDATED
MMASDGHPGPPSVTPGSPLSAGGREWQGMAGSCWNITYVQDSVGPATSTLMFVAGVVGNGLALGILGARRRSHPSAFAVLVTGLAVTDLLGTCFLSPAVFVAYARNSSLLGLAHGGTMLCDTFAFAMTFFGLASTLILFAMAVERCLALSHPYLYAQLDGPRCARFALPSIYAFCCLFCSLPLLGLGEHQQYCPGSWCFIRMRSAQPGGCAFSLAYASLMALLVTSIFFCNGSVTLSLYHMYRQQRRHHGSFVPTSRAREDEVYHLILLALMTVIMAVCSLPLMIRGFTQAIAPDSREMGDLLAFRFNAFNPILDPWVFILFRKAVFQRLKFWLCCLCARSVHGDLQAPLSRPASGRRDPPAPTSLQAKEGSWVPLSSWGTGQVAPLTAVPLTGGDGCSVGMPSKSEAIAACSLC
mat_peptide: 1..412 product: Prostacyclin receptor experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P43252.1) calculated_mol_wt: 44160 peptide sequence: MMASDGHPGPPSVTPGSPLSAGGREWQGMAGSCWNITYVQDSVGPATSTLMFVAGVVGNGLALGILGARRRSHPSAFAVLVTGLAVTDLLGTCFLSPAVFVAYARNSSLLGLAHGGTMLCDTFAFAMTFFGLASTLILFAMAVERCLALSHPYLYAQLDGPRCARFALPSIYAFCCLFCSLPLLGLGEHQQYCPGSWCFIRMRSAQPGGCAFSLAYASLMALLVTSIFFCNGSVTLSLYHMYRQQRRHHGSFVPTSRAREDEVYHLILLALMTVIMAVCSLPLMIRGFTQAIAPDSREMGDLLAFRFNAFNPILDPWVFILFRKAVFQRLKFWLCCLCARSVHGDLQAPLSRPASGRRDPPAPTSLQAKEGSWVPLSSWGTGQVAPLTAVPLTGGDGCSVGMPSKSEAIAAC

Gene Information

Entrez Gene ID
19222
Gene Name
prostaglandin I receptor (IP)
Gene Symbol
Ptgir
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IEA:Ensembl C cytosol
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0004930 IEA:UniProtKB-KW F G-protein coupled receptor activity
GO:0007189 IMP:BHF-UCL P adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0010642 IMP:BHF-UCL P negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0048662 IMP:BHF-UCL P negative regulation of smooth muscle cell proliferation
GO:0030819 IMP:BHF-UCL P positive regulation of cAMP biosynthetic process
GO:0043950 IMP:BHF-UCL P positive regulation of cAMP-mediated signaling
GO:0032496 IMP:MGI P response to lipopolysaccharide

KEGG Pathway Links

KEGG Pathway ID Description
mmu04611 Platelet activation
mmu04270 Vascular smooth muscle contraction

Domain Information

InterPro Annotations

Accession Description
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
IPR000370 Prostacyclin (prostanoid IP) receptor
IPR008365 Prostanoid receptor

UniProt Annotations

Entry Information

Gene Name
prostaglandin I receptor (IP)
Protein Entry
PI2R_MOUSE
UniProt ID
P43252
Species
Mouse

Comments

Comment Type Description
Function Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.
Ptm Isoprenylation does not influence ligand binding but is required for efficient coupling to the effectors adenylyl cyclase and phospholipase C. {ECO:0000269|PubMed:10446129}.
Sequence Caution Sequence=BAA05144.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Subunit Interacts (non-isoprenylated C-terminus) with PDZK1. {ECO:0000269|PubMed:23457445}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002864 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
163965438 RefSeq NP_032993 415 prostacyclin receptor

Identical Sequences to LMP002864 proteins

Reference Database Accession Length Protein Name
GI:163965438 GenBank AAH94386.1 415 Ptgir protein [Mus musculus]
GI:163965438 SwissProt P43252.1 415 RecName: Full=Prostacyclin receptor; AltName: Full=Prostaglandin I2 receptor; Short=PGI receptor; Short=PGI2 receptor; AltName: Full=Prostanoid IP receptor; Flags: Precursor [Mus musculus]

Related Sequences to LMP002864 proteins

Reference Database Accession Length Protein Name
GI:163965438 DBBJ BAA05144.1 417 prostacyclin receptor [Mus musculus]
GI:163965438 DBBJ BAA06091.1 416 prostacyclin receptor [Rattus sp.]
GI:163965438 DBBJ BAE32480.1 417 unnamed protein product [Mus musculus]
GI:163965438 GenBank EDL42070.1 417 prostaglandin I receptor (IP), isoform CRA_a [Mus musculus]
GI:163965438 GenBank EDM08295.1 416 prostaglandin I receptor (IP) (predicted), isoform CRA_b [Rattus norvegicus]
GI:163965438 RefSeq NP_001071112.1 416 prostacyclin receptor [Rattus norvegicus]