Gene/Proteome Database (LMPD)

LMPD ID
LMP002902
Gene ID
339221
Species
Homo sapiens (Human)
Gene Name
ectonucleotide pyrophosphatase/phosphodiesterase 7
Gene Symbol
ENPP7
Synonyms
ALK-SMase; E-NPP 7; NPP-7; NPP7
Chromosome
17
Map Location
17q25.3
EC Number
3.1.4.12

Proteins

ectonucleotide pyrophosphatase/phosphodiesterase family member 7 precursor
Refseq ID NP_848638
Protein GI 530788254
UniProt ID Q6UWV6
mRNA ID NM_178543
Length 458
RefSeq Status VALIDATED
MRGPAVLLTVALATLLAPGAGAPVQSQGSQNKLLLVSFDGFRWNYDQDVDTPNLDAMARDGVKARYMTPAFVTMTSPCHFTLVTGKYIENHGVVHNMYYNTTSKVKLPYHATLGIQRWWDNGSVPIWITAQRQGLRAGSFFYPGGNVTYQGVAVTRSRKEGIAHNYKNETEWRANIDTVMAWFTEEDLDLVTLYFGEPDSTGHRYGPESPERREMVRQVDRTVGYLRESIARNHLTDRLNLIITSDHGMTTVDKRAGDLVEFHKFPNFTFRDIEFELLDYGPNGMLLPKEGRLEKVYDALKDAHPKLHVYKKEAFPEAFHYANNPRVTPLLMYSDLGYVIHGRINVQFNNGEHGFDNKDMDMKTIFRAVGPSFRAGLEVEPFESVHVYELMCRLLGIVPEANDGHLATLLPMLHTESALPPDGRPTLLPKGRSALPPSSRPLLVMGLLGTVILLSEVA
sig_peptide: 1..21 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1992 peptide sequence: MRGPAVLLTVALATLLAPGAG mat_peptide: 22..458 product: Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q6UWV6.3) calculated_mol_wt: 49504 peptide sequence: APVQSQGSQNKLLLVSFDGFRWNYDQDVDTPNLDAMARDGVKARYMTPAFVTMTSPCHFTLVTGKYIENHGVVHNMYYNTTSKVKLPYHATLGIQRWWDNGSVPIWITAQRQGLRAGSFFYPGGNVTYQGVAVTRSRKEGIAHNYKNETEWRANIDTVMAWFTEEDLDLVTLYFGEPDSTGHRYGPESPERREMVRQVDRTVGYLRESIARNHLTDRLNLIITSDHGMTTVDKRAGDLVEFHKFPNFTFRDIEFELLDYGPNGMLLPKEGRLEKVYDALKDAHPKLHVYKKEAFPEAFHYANNPRVTPLLMYSDLGYVIHGRINVQFNNGEHGFDNKDMDMKTIFRAVGPSFRAGLEVEPFESVHVYELMCRLLGIVPEANDGHLATLLPMLHTESALPPDGRPTLLPKGRSALPPSSRPLLVMGLLGTVILLSEVA

Gene Information

Entrez Gene ID
339221
Gene Name
ectonucleotide pyrophosphatase/phosphodiesterase 7
Gene Symbol
ENPP7
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IDA:UniProtKB C Golgi apparatus
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016020 NAS:UniProtKB C membrane
GO:0005902 IDA:UniProtKB C microvillus
GO:0005886 TAS:Reactome C plasma membrane
GO:0004767 IDA:UniProtKB F sphingomyelin phosphodiesterase activity
GO:0006687 TAS:Reactome P glycosphingolipid metabolic process
GO:0008156 IDA:UniProtKB P negative regulation of DNA replication
GO:0008285 IDA:UniProtKB P negative regulation of cell proliferation
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0006665 TAS:Reactome P sphingolipid metabolic process
GO:0006684 IDA:UniProtKB P sphingomyelin metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa01100 Metabolic pathways
hsa00600 Sphingolipid metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY3DJ-11281 sphingomyelin metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_116105 Glycosphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR017849 Alkaline phosphatase-like, alpha/beta/alpha
IPR017850 Alkaline-phosphatase-like, core domain
IPR024873 Ectonucleotide pyrophosphatase/phosphodiesterase family
IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase

UniProt Annotations

Entry Information

Gene Name
ectonucleotide pyrophosphatase/phosphodiesterase 7
Protein Entry
Q6UWV6_HUMAN
UniProt ID
Q6UWV6
Species
Human

Comments

Comment Type Description
Catalytic Activity Sphingomyelin + H(2)O = N-acylsphingosine + phosphocholine.
Enzyme Regulation Inhibited in a dose dependent manner by ATP, imidazole, orthovanadate and zinc ion. Not inhibited by ADP, AMP and EDTA.
Function Converts sphingomyelin to ceramide. Also has phospholipase C activity toward palmitoyl lyso-phosphocholine. Does not appear to have nucleotide pyrophosphatase activity.
Miscellaneous Decreased levels of alkaline sphingomyelin phosphodiesterase may be associated with colon cancer.
Ptm N-glycosylated; required for activity and transport to the plasma membrane. {ECO
Similarity Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
Subcellular Location Membrane {ECO
Tissue Specificity Detected in the colon (at protein level). Expressed in the duodenum, jejunum and liver and at low levels in the ileum. Expression was very low in the esophagus, stomach and colon.
Web Resource Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/ENPP7ID44055ch17q25.html";

Identical and Related Proteins

Unique RefSeq proteins for LMP002902 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
530788254 RefSeq NP_848638 458 ectonucleotide pyrophosphatase/phosphodiesterase family member 7 precursor

Identical Sequences to LMP002902 proteins

Reference Database Accession Length Protein Name
GI:530788254 GenBank AAH41453.2 458 Ectonucleotide pyrophosphatase/phosphodiesterase 7 [Homo sapiens]
GI:530788254 GenBank AAP69661.1 458 intestinal alkaline sphingomyelinase [Homo sapiens]
GI:530788254 GenBank AIC58148.1 458 ENPP7, partial [synthetic construct]

Related Sequences to LMP002902 proteins

Reference Database Accession Length Protein Name
GI:530788254 DBBJ BAC86504.1 531 unnamed protein product [Homo sapiens]
GI:530788254 GenBank EAW89566.1 464 ectonucleotide pyrophosphatase/phosphodiesterase 7, partial [Homo sapiens]
GI:530788254 GenBank ABN29436.1 458 Sequence 14 from patent US 7164001
GI:530788254 GenBank ACE15375.1 458 Sequence 14 from patent US 7365157
GI:530788254 GenBank AHE02226.1 458 Sequence 60580 from patent US 8586006
GI:530788254 SwissProt Q6UWV6.3 458 RecName: Full=Ectonucleotide pyrophosphatase/phosphodiesterase family member 7; Short=E-NPP 7; Short=NPP-7; AltName: Full=Alkaline sphingomyelin phosphodiesterase; AltName: Full=Intestinal alkaline sphingomyelinase; Short=Alk-SMase; Flags: Precursor [Homo sapiens]