Gene/Proteome Database (LMPD)
LMPD ID
LMP002923
Gene ID
Species
Mus musculus (Mouse)
Gene Name
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6
Gene Symbol
Synonyms
D19210
Alternate Names
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 6; 3beta-HSD VI; 3-beta-HSD VI; hydroxysteroid dehydrogenase-6, delta<5>-3-beta; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type VI; hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6 pseudogene
Chromosome
3
Map Location
3 F2.2|3
EC Number
1.1.1.-
Proteins
| 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 6 | |
|---|---|
| Refseq ID | NP_038849 |
| Protein GI | 162461883 |
| UniProt ID | O35469 |
| mRNA ID | NM_013821 |
| Length | 373 |
| RefSeq Status | VALIDATED |
| MPGWSCLVTGAGGFLGQRIVQLLMQEKDLEEIRVLDKFFRPETREQFFNLDTNIKVTVLEGDILDTQYLRKACQGISVVIHTAAVIDVTGVIPRQTILDVNLKGTQNLLEACIQASVPAFIFSSSVDVAGPNSYKEIILNGNEEEHHESIWSDPYPYSKKMAEKAVLAANGSMLKIGGTLHTCALRPMYIYGERSPFISNTIITALKNKNILGCTGKFSTANPVYVGNVAWAHILAARGLRDPKKSPNIQGEFYYISDDTPHQSYDDLNYTLSKEWGFCPDSSWSLPVPLLYWLAFMLETVSFLLSPIYRFIPPFNRHLVTLTGSTFTFSYKKAQRDLGYEPLVSWEEAKQKTSEWIGTLVEQHRETLDTKSQ | |
Gene Information
Entrez Gene ID
Gene Name
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6
Gene Symbol
Species
Mus musculus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005783 | IEA:UniProtKB-KW | C | endoplasmic reticulum |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0005739 | IEA:UniProtKB-KW | C | mitochondrion |
| GO:0003854 | IEA:UniProtKB-EC | F | 3-beta-hydroxy-delta5-steroid dehydrogenase activity |
| GO:0004769 | IEA:UniProtKB-EC | F | steroid delta-isomerase activity |
| GO:0006694 | IEA:UniProtKB-UniPathway | P | steroid biosynthetic process |
KEGG Pathway Links
Domain Information
UniProt Annotations
Entry Information
Gene Name
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6
Protein Entry
3BHS6_MOUSE
UniProt ID
Species
Mouse
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | A 3-beta-hydroxy-Delta(5)-steroid + NAD(+) = a 3-oxo-Delta(5)-steroid + NADH. |
| Catalytic Activity | A 3-oxo-Delta(5)-steroid = a 3-oxo-Delta(4)- steroid. |
| Developmental Stage | Earliest isoform to be expressed during embryogenesis in cells of embryonic origin at 7 and 9.5 dpc, and is the major isoform expressed in uterine tissue at the time of implantation (4.5 dpc) and continues to be expressed in uterine tissue at 6.5, 7.5 and 9.5 dpc. It is expressed in giant trophoblasts at 9.5 dpc and is expressed in the placenta through 15.5 dpc. |
| Function | 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. May be involved in local production of progesterone. |
| Pathway | Lipid metabolism; steroid biosynthesis. |
| Similarity | Belongs to the 3-beta-HSD family. {ECO:0000305}. |
| Subcellular Location | Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. |
| Tissue Specificity | Expressed in skin and testis. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002923 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 162461883 | RefSeq | NP_038849 | 373 | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 6 |
Identical Sequences to LMP002923 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:162461883 | DBBJ | BAE25002.1 | 373 | unnamed protein product [Mus musculus] |
| GI:162461883 | GenBank | EDL38971.1 | 373 | mCG19918 [Mus musculus] |
| GI:162461883 | SwissProt | O35469.4 | 373 | RecName: Full=3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 6; AltName: Full=3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type VI; Short=3-beta-HSD VI; Includes: RecName: Full=3-beta-hydroxy-Delta(5)-steroid dehydrogenase; AltName: Full=3-beta-hydroxy-5-ene steroid dehydrogenase; AltName: Full=Progesterone reductase; Includes: RecName: Full=Steroid Delta-isomerase; AltName: Full=Delta-5-3-ketosteroid isomerase [Mus musculus] |
Related Sequences to LMP002923 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:162461883 | DBBJ | BAD05114.1 | 373 | 3beta-hydroxysteroid dehydrogenase VI [Mus musculus] |
| GI:162461883 | GenBank | AAB84299.1 | 373 | 3beta-hydroxysteroid dehydrogenase isoform VI [Mus musculus] |
| GI:162461883 | GenBank | AAL02366.1 | 373 | 3 beta-hydroxysteroid dehydrogenase isomerase VI [Mus musculus] |
| GI:162461883 | GenBank | AAH53501.1 | 373 | Hsd3b6 protein [Mus musculus] |
| GI:162461883 | RefSeq | NP_694873.2 | 373 | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 [Mus musculus] |
| GI:162461883 | SwissProt | P26149.4 | 373 | RecName: Full=3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2; AltName: Full=3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II; Short=3-beta-HSD II; Includes: RecName: Full=3-beta-hydroxy-Delta(5)-steroid dehydrogenase; AltName: Full=3-beta-hydroxy-5-ene steroid dehydrogenase; AltName: Full=Progesterone reductase; Includes: RecName: Full=Steroid Delta-isomerase; AltName: Full=Delta-5-3-ketosteroid isomerase [Mus musculus] |