Gene/Proteome Database (LMPD)

LMPD ID
LMP002997
Gene ID
51170
Species
Homo sapiens (Human)
Gene Name
hydroxysteroid (17-beta) dehydrogenase 11
Gene Symbol
HSD17B11
Synonyms
17-BETA-HSD11; 17-BETA-HSDXI; 17BHSD11; DHRS8; PAN1B; RETSDR2; SDR16C2
Alternate Names
estradiol 17-beta-dehydrogenase 11; CTCL tumor antigen HD-CL-03; CTCL-associated antigen HD-CL-03; dehydrogenase/reductase SDR family member 8; 17-beta-hydroxysteroid dehydrogenase type XI; retinal short-chain dehydrogenase/reductase 2; cutaneous T-cell lymphoma-associated antigen HD-CL-03; short chain dehydrogenase/reductase family 16C, member 2
Chromosome
4
Map Location
4q22.1
EC Number
1.1.1.62
Summary
Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones (Brereton et al., 2001 [PubMed 11165019]).[supplied by OMIM, Jun 2009]
Orthologs
View orthologs and multiple alignments for HSD17B11

Proteins

estradiol 17-beta-dehydrogenase 11 precursor
Refseq ID NP_057329
Protein GI 613410229
UniProt ID Q8NBQ5
mRNA ID NM_016245
Length 300
RefSeq Status VALIDATED
MKFLLDILLLLPLLIVCSLESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGLGAKVHTFVVDCSNREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNTGFIKNPSTSLGPTLEPEEVVNRLMHGILTEQKMIFIPSSIAFLTTLERILPERFLAVLKRKISVKFDAVIGYKMKAQ
sig_peptide: 1..19 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2171 peptide sequence: MKFLLDILLLLPLLIVCSL mat_peptide: 20..300 product: Estradiol 17-beta-dehydrogenase 11 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q8NBQ5.3) calculated_mol_wt: 30811 peptide sequence: ESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGLGAKVHTFVVDCSNREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNTGFIKNPSTSLGPTLEPEEVVNRLMHGILTEQKMIFIPSSIAFLTTLERILPERFLAVLKRKISVKFDAVIGYKMKAQ

Gene Information

Entrez Gene ID
51170
Gene Name
hydroxysteroid (17-beta) dehydrogenase 11
Gene Symbol
HSD17B11
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:HGNC C cytoplasm
GO:0005576 IEA:UniProtKB-KW C extracellular region
GO:0005811 IDA:UniProtKB C lipid particle
GO:0004303 IEA:UniProtKB-EC F estradiol 17-beta-dehydrogenase activity
GO:0016229 IDA:HGNC F steroid dehydrogenase activity
GO:0006710 IDA:HGNC P androgen catabolic process
GO:0006694 IEA:UniProtKB-KW P steroid biosynthetic process

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY66-380 estrogen biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR002347 Glucose/ribitol dehydrogenase
IPR016040 NAD(P)-binding domain
IPR002198 Short-chain dehydrogenase/reductase SDR

UniProt Annotations

Entry Information

Gene Name
hydroxysteroid (17-beta) dehydrogenase 11
Protein Entry
DHB11_HUMAN
UniProt ID
Q8NBQ5
Species
Human

Comments

Comment Type Description
Catalytic Activity 17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
Function Can convert androstan-3-alpha,17-beta-diol (3-alpha- diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor- associated antigen in cutaneous T-cell lymphoma.
Similarity Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.
Subcellular Location Secreted .
Tissue Specificity Present at high level in steroidogenic cells such as syncytiotrophoblasts, sebaceous gland, Leydig cells, and granulosa cells of the dominant follicle and corpus luteum. In lung, it is detected in the ciliated epithelium and in acini of adult trachea, in bronchioles, but not in alveoli. In the eye, it is detected in the nonpigmented epithelium of the ciliary body and, at lower level, in the inner nuclear layer of the retina (at protein level). Widely expressed. Highly expressed in retina, pancreas, kidney, liver, lung, adrenal, small intestine, ovary and heart. {ECO

Identical and Related Proteins

Unique RefSeq proteins for LMP002997 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
613410229 RefSeq NP_057329 300 estradiol 17-beta-dehydrogenase 11 precursor

Identical Sequences to LMP002997 proteins

Reference Database Accession Length Protein Name
GI:613410229 GenBank JAA09120.1 300 hydroxysteroid (17-beta) dehydrogenase 11 [Pan troglodytes]
GI:613410229 GenBank JAA36225.1 300 hydroxysteroid (17-beta) dehydrogenase 11 [Pan troglodytes]
GI:613410229 GenBank AGV96398.1 300 Sequence 477 from patent US 8513189
GI:613410229 GenBank AGV96399.1 300 Sequence 478 from patent US 8513189
GI:613410229 GenBank AHD74518.1 300 Sequence 14535 from patent US 8586006
GI:613410229 GenBank AIC56401.1 300 HSD17B11, partial [synthetic construct]

Related Sequences to LMP002997 proteins

Reference Database Accession Length Protein Name
GI:613410229 DBBJ BAC11560.1 300 unnamed protein product [Homo sapiens]
GI:613410229 EMBL CAC39693.1 300 unnamed protein product [Homo sapiens]
GI:613410229 EMBL CAI72064.1 300 unnamed protein product [Homo sapiens]
GI:613410229 GenBank AAW11817.1 300 Sequence 8 from patent US 6808895
GI:613410229 GenBank ABL23953.1 300 Sequence 24 from patent US 7129338
GI:613410229 SwissProt Q8NBQ5.3 300 RecName: Full=Estradiol 17-beta-dehydrogenase 11; AltName: Full=17-beta-hydroxysteroid dehydrogenase 11; Short=17-beta-HSD 11; Short=17bHSD11; Short=17betaHSD11; AltName: Full=17-beta-hydroxysteroid dehydrogenase XI; Short=17-beta-HSD XI; Short=17betaHSDXI; AltName: Full=Cutaneous T-cell lymphoma-associated antigen HD-CL-03; Short=CTCL-associated antigen HD-CL-03; AltName: Full=Dehydrogenase/reductase SDR family member 8; AltName: Full=Retinal short-chain dehydrogenase/reductase 2; Short=retSDR2; Flags: Precursor [Homo sapiens]