Gene/Proteome Database (LMPD)

LMPD ID
LMP003004
Gene ID
214084
Species
Mus musculus (Mouse)
Gene Name
solute carrier family 18 (vesicular monoamine), member 2
Gene Symbol
Slc18a2
Synonyms
1110037L13Rik; 9330105E13; Vmat2
Alternate Names
synaptic vesicular amine transporter; VAT2; monoamine transporter; vesicular amine transporter 2; solute carrier family 18 member 2; vesicular monoamine transporter 2
Chromosome
19
Map Location
19 D3|19 54.64 cM

Proteins

synaptic vesicular amine transporter
Refseq ID NP_766111
Protein GI 27369732
UniProt ID Q8BRU6
mRNA ID NM_172523
Length 517
RefSeq Status VALIDATED
MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNTTEIQTARPALTASTSESFHSIFSYYNNSTVFTGNATGGLPGGESPKATTTQHTVTNTTVPPDCPSEDKDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNAMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMIVVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIVFAPLCFFLRSPPAKEEKMAILMDHNCPIKTKMYTQNNVQPYPVGDDEESESD

Gene Information

Entrez Gene ID
214084
Gene Name
solute carrier family 18 (vesicular monoamine), member 2
Gene Symbol
Slc18a2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0031045 IEA:Ensembl C dense core granule
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0043025 IEA:Ensembl C neuronal cell body
GO:0030672 IEA:Ensembl C synaptic vesicle membrane
GO:0043195 IEA:Ensembl C terminal bouton
GO:0005275 IEA:Ensembl F amine transmembrane transporter activity
GO:0008144 IEA:Ensembl F drug binding
GO:0015238 IEA:InterPro F drug transmembrane transporter activity
GO:0015222 IEA:Ensembl F serotonin transmembrane transporter activity
GO:0007568 IEA:Ensembl P aging
GO:0071242 IEA:Ensembl P cellular response to ammonium ion
GO:0035690 IEA:Ensembl P cellular response to drug
GO:0016265 IMP:MGI P death
GO:0032456 IEA:Ensembl P endocytic recycling
GO:0042593 IEA:Ensembl P glucose homeostasis
GO:0030073 IEA:Ensembl P insulin secretion
GO:0007626 IMP:MGI P locomotory behavior
GO:0051589 IEA:Ensembl P negative regulation of neurotransmitter transport
GO:0006836 IEA:UniProtKB-KW P neurotransmitter transport
GO:0009791 IMP:MGI P post-embryonic development
GO:0001975 IMP:MGI P response to amphetamine
GO:0042220 IEA:Ensembl P response to cocaine
GO:0051412 IEA:Ensembl P response to corticosterone
GO:0009635 IEA:Ensembl P response to herbicide
GO:0042594 IEA:Ensembl P response to starvation
GO:0009636 IMP:MGI P response to toxic substance
GO:0010043 IEA:Ensembl P response to zinc ion

KEGG Pathway Links

KEGG Pathway ID Description
mmu05034 Alcoholism
mmu05031 Amphetamine addiction
mmu05030 Cocaine addiction
mmu04726 Serotonergic synapse

Domain Information

InterPro Annotations

Accession Description
IPR011701 Major facilitator superfamily
IPR020846 Major facilitator superfamily domain
IPR004734 Multidrug resistance protein

UniProt Annotations

Entry Information

Gene Name
solute carrier family 18 (vesicular monoamine), member 2
Protein Entry
VMAT2_MOUSE
UniProt ID
Q8BRU6
Species
Mouse

Comments

Comment Type Description
Function Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis (By similarity). {ECO:0000250}.
Similarity Belongs to the major facilitator superfamily. Vesicular transporter family. {ECO:0000305}.
Subcellular Location Cytoplasmic vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Subunit Interacts with SLC6A3. {ECO:0000269|PubMed:19357284}.

Identical and Related Proteins

Unique RefSeq proteins for LMP003004 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
27369732 RefSeq NP_766111 517 synaptic vesicular amine transporter

Identical Sequences to LMP003004 proteins

Reference Database Accession Length Protein Name
GI:27369732 DBBJ BAC30887.1 517 unnamed protein product [Mus musculus]
GI:27369732 EMBL CAD88262.1 517 vesicular monoamine transporter 2 [Mus musculus]
GI:27369732 SwissProt Q8BRU6.1 517 RecName: Full=Synaptic vesicular amine transporter; AltName: Full=Monoamine transporter; AltName: Full=Solute carrier family 18 member 2; AltName: Full=Vesicular amine transporter 2; Short=VAT2 [Mus musculus]

Related Sequences to LMP003004 proteins

Reference Database Accession Length Protein Name
GI:27369732 DBBJ BAC28501.1 517 unnamed protein product [Mus musculus]
GI:27369732 GenBank AAA41627.1 515 monoamine transporter [Rattus norvegicus]
GI:27369732 GenBank EDL01823.1 527 solute carrier family 18 (vesicular monoamine), member 2, partial [Mus musculus]
GI:27369732 GenBank EDL94557.1 515 solute carrier family 18 (vesicular monoamine), member 2, isoform CRA_a [Rattus norvegicus]
GI:27369732 RefSeq NP_037163.1 515 synaptic vesicular amine transporter [Rattus norvegicus]
GI:27369732 RefSeq XP_006231726.1 515 PREDICTED: synaptic vesicular amine transporter isoform X1 [Rattus norvegicus]