Gene/Proteome Database (LMPD)

LMPD ID
LMP003007
Gene ID
233552
Species
Mus musculus (Mouse)
Gene Name
glycerophosphodiester phosphodiesterase domain containing 5
Gene Symbol
Gdpd5
Synonyms
BC024955; Gde2
Alternate Names
glycerophosphodiester phosphodiesterase domain-containing protein 5; glycerophosphodiester phosphodiesterase 2
Chromosome
7
Map Location
7 E2|7
EC Number
3.1.-.-

Proteins

glycerophosphodiester phosphodiesterase domain-containing protein 5
Refseq ID NP_958740
Protein GI 52345431
UniProt ID Q640M6
mRNA ID NM_201352
Length 607
RefSeq Status PROVISIONAL
MVRHQPLQYYEPQLCLSCLTGIYGCRWKRYQRSHDDTTPWERLWFLLLVCTFSLTLTWLYFWWGVHNDYDEFNWYLYNRMGYWSDWSVPILVTSAAAFTYIAGLLVLALCHIAVGQQLNLHWIHKMGLVVILASTVVAMSAVAQLWEDEWEVLLISLQGTAPFLHIGALVAITALSWIVAGQFARAERSSSQLTILCTFFAVVFTFYLIPLTISSPCIMEKKDLGPKPALIGHRGAPMLAPEHTVMSFRKALEQRLYGLQADITISLDGVPFLMHDTTLRRTTNVEHLFPELARRPAAMLNWTVLQRLNAGQWFLKTDPFWTASSLSPSDHREVQNQSICSLAELLELAKGNASLLLNLRDPPRDHPYRGSFLNVTLEAVLRSGFPQHQVMWLFNRQRPLVRKMAPGFQQTSGSKEAIANLRKGHIQKLNLRYTQVSHQELRDYASWNLSVNLYTVNAPWLFSLLWCAGVPSVTSDNSHTLSRVPSPLWIMPPDEYCLMWVTADLISFSLIIGIFVLQKWRLGGIRSYNPEQIMLSAAVRRTSRDVSIMKEKLIFSEISDGVEVSDELSVCSDSSYDTYANANSTATPVGPRNAGSRAKTVTEQSGH

Gene Information

Entrez Gene ID
233552
Gene Name
glycerophosphodiester phosphodiesterase domain containing 5
Gene Symbol
Gdpd5
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0042995 IEA:UniProtKB-KW C cell projection
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016020 IDA:MGI C membrane
GO:0008889 IEA:InterPro F glycerophosphodiester phosphodiesterase activity
GO:0021895 IMP:MGI P cerebral cortex neuron differentiation
GO:0006071 IEA:InterPro P glycerol metabolic process
GO:0006629 IEA:InterPro P lipid metabolic process
GO:0045746 IMP:MGI P negative regulation of Notch signaling pathway
GO:0031175 IMP:MGI P neuron projection development
GO:0045666 IMP:MGI P positive regulation of neuron differentiation
GO:0048505 IMP:MGI P regulation of timing of cell differentiation
GO:0021522 IMP:MGI P spinal cord motor neuron differentiation

Domain Information

InterPro Annotations

Accession Description
IPR004129 Glycerophosphoryl diester phosphodiesterase
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain

UniProt Annotations

Entry Information

Gene Name
glycerophosphodiester phosphodiesterase domain containing 5
Protein Entry
GDPD5_MOUSE
UniProt ID
Q640M6
Species
Mouse

Comments

Comment Type Description
Function Promotes neurite formation. Cooperates with PRDX1 to drive postmitotic motor neuron differentiation. The glycerophosphodiester phosphodiesterase activity may be required for its role in neuronal differentiation. May contribute to the osmotic regulation of cellular glycerophosphocholine. {ECO:0000269|PubMed:17275818, ECO:0000269|PubMed:18667693}.
Induction Up-regulated during neuronal differentiation by retinoic acid. {ECO:0000269|PubMed:17275818}.
Ptm Intramolecular disulfide bond between Cys-25 and Cys-571 is reduced by PRDX1. {ECO:0000250}.
Sequence Caution Sequence=AAH26428.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Belongs to the glycerophosphoryl diester phosphodiesterase family. {ECO:0000305}.
Similarity Contains 1 GP-PDE domain. {ECO:0000305}.
Subcellular Location Endomembrane system {ECO:0000305}; Multi- pass membrane protein {ECO:0000305}. Cytoplasm, perinuclear region. Cell projection, growth cone. Note=In a punctate perinuclear pattern.
Subunit Interacts with PRDX1; forms a mixed-disulfide with PRDX1, leading to disrupt intramolecular disulfide bond between Cys-25 and Cys-571. {ECO:0000250}.
Tissue Specificity Detected in brain, lung, heart, kidney and testis. {ECO:0000269|PubMed:15276213}.

Identical and Related Proteins

Unique RefSeq proteins for LMP003007 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
52345431 RefSeq NP_958740 607 glycerophosphodiester phosphodiesterase domain-containing protein 5

Identical Sequences to LMP003007 proteins

Reference Database Accession Length Protein Name
GI:52345431 DBBJ BAE24577.1 607 unnamed protein product [Mus musculus]
GI:52345431 DBBJ BAE32819.1 607 unnamed protein product [Mus musculus]
GI:52345431 GenBank AAH82585.1 607 Glycerophosphodiester phosphodiesterase domain containing 5 [Mus musculus]
GI:52345431 GenBank EDL16381.1 607 glycerophosphodiester phosphodiesterase domain containing 5, isoform CRA_c [Mus musculus]
GI:52345431 GenBank EDL16382.1 607 glycerophosphodiester phosphodiesterase domain containing 5, isoform CRA_c [Mus musculus]
GI:52345431 SwissProt Q640M6.1 607 RecName: Full=Glycerophosphodiester phosphodiesterase domain-containing protein 5; AltName: Full=Glycerophosphodiester phosphodiesterase 2 [Mus musculus]

Related Sequences to LMP003007 proteins

Reference Database Accession Length Protein Name
GI:52345431 GenBank AAH24955.1 607 Glycerophosphodiester phosphodiesterase domain containing 5 [Mus musculus]
GI:52345431 RefSeq XP_006223483.1 605 PREDICTED: glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform X2 [Rattus norvegicus]
GI:52345431 RefSeq XP_006229879.1 605 PREDICTED: glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform X2 [Rattus norvegicus]
GI:52345431 RefSeq XP_006507695.1 612 PREDICTED: glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform X1 [Mus musculus]
GI:52345431 RefSeq XP_006507696.1 612 PREDICTED: glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform X2 [Mus musculus]
GI:52345431 RefSeq XP_006507697.1 612 PREDICTED: glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform X3 [Mus musculus]