Gene/Proteome Database (LMPD)

LMPD ID
LMP003386
Gene ID
55711
Species
Homo sapiens (Human)
Gene Name
fatty acyl CoA reductase 2
Gene Symbol
FAR2
Synonyms
MLSTD1; SDR10E2
Chromosome
12
Map Location
12p11.22
Summary
This gene belongs to the short chain dehydrogenase/reductase superfamily. It encodes a reductase enzyme involved in the first step of wax biosynthesis wherein fatty acids are converted to fatty alcohols. The encoded peroxisomal protein utilizes saturated fatty acids of 16 or 18 carbons as preferred substrates. Alternatively spliced transcript variants have been observed for this gene. Related pseudogenes have been identified on chromosomes 2, 14 and 22. [provided by RefSeq, Nov 2012]
Orthologs
View orthologs and multiple alignments for FAR2

Proteins

fatty acyl-CoA reductase 2 isoform 1
Refseq ID NP_060569
Protein GI 31542658
UniProt ID Q9NUX8
mRNA ID NM_018099
Length 515
RefSeq Status REVIEWED
MSTIAAFYGGKSILITGATGFLGKVLMEKLFRTSPDLKVIYILVRPKAGQTLQQRVFQILDSKLFEKVKEVCPNVHEKIRAIYADLNQNDFAISKEDMQELLSCTNIIFHCAATVRFDDTLRHAVQLNVTATRQLLLMASQMPKLEAFIHISTAYSNCNLKHIDEVIYPCPVEPKKIIDSLEWLDDAIIDEITPKLIRDWPNIYTYTKALGEMVVQQESRNLNIAIIRPSIVGATWQEPFPGWVDNINGPNGIIIATGKGFLRAIKATPMAVADVIPVDTVVNLMLAVGWYTAVHRPKSTLVYHITSGNMNPCNWHKMGVQVLATFEKIPFERPFRRPNANFTSNSFTSQYWNAVSHRAPAIIYDCYLRLTGRKPRMTKLMNRLLRTVSMLEYFINRSWEWSTYNTEMLMSELSPEDQRVFNFDVRQLNWLEYIENYVLGVKKYLLKEDMAGIPKAKQRLKRLRNIHYLFNTALFLIAWRLLIARSQMARNVWFFIVSFCYKFLSYFRASSTLKV
fatty acyl-CoA reductase 2 isoform 1
Refseq ID NP_001258712
Protein GI 422398861
UniProt ID Q9NUX8
mRNA ID NM_001271783
Length 515
RefSeq Status REVIEWED
Protein sequence is identical to GI:31542658 (mRNA isoform)
fatty acyl-CoA reductase 2 isoform 2
Refseq ID NP_001258713
Protein GI 422398861
UniProt ID Q9NUX8
mRNA ID NM_001271784
Length 515
RefSeq Status REVIEWED
Protein sequence is identical to GI:31542658 (mRNA isoform)

Gene Information

Entrez Gene ID
55711
Gene Name
fatty acyl CoA reductase 2
Gene Symbol
FAR2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0080019 IEA:InterPro F fatty-acyl-CoA reductase (alcohol-forming) activity

KEGG Pathway Links

KEGG Pathway ID Description
hsa04146 Peroxisome
ko04146 Peroxisome

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_16957 Peroxisomal lipid metabolism
REACT_1407 Plasmalogen biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR026055 Fatty acyl-CoA reductase
IPR013120 Male sterility, NAD-binding
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
fatty acyl CoA reductase 2
Protein Entry
FACR2_HUMAN
UniProt ID
Q9NUX8
Species
Human

Identical and Related Proteins

Unique RefSeq proteins for LMP003386 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
31542658 RefSeq NP_060569 515 fatty acyl-CoA reductase 2 isoform 1

Identical Sequences to LMP003386 proteins

Reference Database Accession Length Protein Name
GI:31542658 GenBank EAW96586.1 515 male sterility domain containing 1, isoform CRA_a [Homo sapiens]
GI:31542658 GenBank EAW96587.1 515 male sterility domain containing 1, isoform CRA_a [Homo sapiens]
GI:31542658 GenBank ACE17018.1 515 Sequence 2 from patent US 7368270
GI:31542658 GenBank AHD71611.1 515 Sequence 6305 from patent US 8586006
GI:31542658 GenBank AIC51825.1 515 FAR2, partial [synthetic construct]
GI:31542658 RefSeq NP_001258712.1 515 fatty acyl-CoA reductase 2 isoform 1 [Homo sapiens]

Related Sequences to LMP003386 proteins

Reference Database Accession Length Protein Name
GI:31542658 DBBJ BAA91625.1 515 unnamed protein product [Homo sapiens]
GI:31542658 DBBJ BAA91983.1 515 unnamed protein product [Homo sapiens]
GI:31542658 EMBL CAB66777.1 515 hypothetical protein [Homo sapiens]
GI:31542658 EMBL CAE89305.1 515 unnamed protein product [Homo sapiens]
GI:31542658 EMBL CAE89899.1 515 unnamed protein product [Homo sapiens]
GI:31542658 GenBank AED82303.1 515 Sequence 1040 from patent US 7919467