Gene/Proteome Database (LMPD)

LMPD ID
LMP003412
Gene ID
10901
Species
Homo sapiens (Human)
Gene Name
dehydrogenase/reductase (SDR family) member 4
Gene Symbol
DHRS4
Synonyms
CR; NRDR; PHCR; PSCD; SCAD-SRL; SDR-SRL; SDR25C1; SDR25C2
Alternate Names
dehydrogenase/reductase SDR family member 4; peroxisomal short-chain alcohol dehydrogenase; NADPH-dependent retinol dehydrogenase/reductase; short-chain dehydrogenase/reductase family member 4; dehydrogenase/reductase (SDR family) member 4 like 2A; short chain dehydrogenase/reductase family 25C, member 1; short chain dehydrogenase/reductase family 25C, member 2; NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase
Chromosome
14
Map Location
14q11.2
EC Number
1.1.1.184

Proteins

dehydrogenase/reductase SDR family member 4 isoform 1
Refseq ID NP_066284
Protein GI 32483357
UniProt ID Q9BTZ2
mRNA ID NM_021004
Length 278
RefSeq Status VALIDATED
MHKAGLLGLCARAWNSVRMASSGMTRRDPLANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDCAGIVSFLCSEDASYITGETVVVGGGTPSRL
dehydrogenase/reductase SDR family member 4 isoform 2
Refseq ID NP_001269916
Protein GI 545479056
UniProt ID Q9BTZ2
mRNA ID NM_001282987
Length 188
RefSeq Status VALIDATED
MHKAGLLGLCARAWNSVRMASSGMTRRDPLANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKRRLSGDRVFHSSLQSISSLDGQGKRGKHERNPADKKVRRARGLCWHRVFPVL
dehydrogenase/reductase SDR family member 4 isoform 3
Refseq ID NP_001269917
Protein GI 545478136
UniProt ID Q9BTZ2
mRNA ID NM_001282988
Length 244
RefSeq Status VALIDATED
MHKAGLLGLCARAWNSVRMASSGMTRRDPLANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAEDRERLVATTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDCAGIVSFLCSEDASYITGETVVVGGGTPSRL
dehydrogenase/reductase SDR family member 4 isoform 4
Refseq ID NP_001269918
Protein GI 545478136
UniProt ID Q9BTZ2
mRNA ID NM_001282989
Length 244
RefSeq Status VALIDATED
MHKAGLLGLCARAWNSVRMASSGMTRRDPLANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAEDRERLVATTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDCAGIVSFLCSEDASYITGETVVVGGGTPSRL
dehydrogenase/reductase SDR family member 4 isoform 5
Refseq ID NP_001269919
Protein GI 545478136
UniProt ID Q9BTZ2
mRNA ID NM_001282990
Length 244
RefSeq Status VALIDATED
MHKAGLLGLCARAWNSVRMASSGMTRRDPLANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAEDRERLVATTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDCAGIVSFLCSEDASYITGETVVVGGGTPSRL
dehydrogenase/reductase SDR family member 4 isoform 6
Refseq ID NP_001269920
Protein GI 545478136
UniProt ID Q9BTZ2
mRNA ID NM_001282991
Length 244
RefSeq Status VALIDATED
MHKAGLLGLCARAWNSVRMASSGMTRRDPLANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAEDRERLVATTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDCAGIVSFLCSEDASYITGETVVVGGGTPSRL

Gene Information

Entrez Gene ID
10901
Gene Name
dehydrogenase/reductase (SDR family) member 4
Gene Symbol
DHRS4
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0043231 IDA:HPA C intracellular membrane-bounded organelle
GO:0005739 ISS:UniProtKB C mitochondrion
GO:0031965 IDA:HPA C nuclear membrane
GO:0005634 IDA:UniProtKB C nucleus
GO:0005778 IDA:UniProtKB C peroxisomal membrane
GO:0005777 IDA:UniProtKB C peroxisome
GO:0000253 IDA:UniProtKB F 3-keto sterol reductase activity
GO:0018455 IDA:UniProtKB F alcohol dehydrogenase [NAD(P)+] activity
GO:0004090 IDA:UniProtKB F carbonyl reductase (NADPH) activity
GO:0016655 IDA:UniProtKB F oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0005102 IPI:UniProtKB F receptor binding
GO:0006066 IDA:UniProtKB P alcohol metabolic process
GO:0042180 IDA:UniProtKB P cellular ketone metabolic process
GO:0055114 IDA:UniProtKB P oxidation-reduction process
GO:0051262 IDA:UniProtKB P protein tetramerization
GO:0008202 IDA:UniProtKB P steroid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa01100 Metabolic pathways
hsa04146 Peroxisome
ko04146 Peroxisome
hsa00830 Retinol metabolism

Domain Information

InterPro Annotations

Accession Description
IPR029511 Dehydrogenase/reductase SDR member 4-like
IPR002347 Glucose/ribitol dehydrogenase
IPR016040 NAD(P)-binding domain
IPR002198 Short-chain dehydrogenase/reductase SDR
IPR020904 Short-chain dehydrogenase/reductase, conserved site

UniProt Annotations

Entry Information

Gene Name
dehydrogenase/reductase (SDR family) member 4
Protein Entry
DHRS4_HUMAN
UniProt ID
Q9BTZ2
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=8; Name=1; Synonyms=SDR-SRL3; IsoId=Q9BTZ2-1; Sequence=Displayed; Name=2; Synonyms=SDR-SRL1; IsoId=Q9BTZ2-2; Sequence=VSP_008586; Name=3; Synonyms=SDR-SRL2; IsoId=Q9BTZ2-3; Sequence=VSP_008585; Name=4; Synonyms=NRDRB1; IsoId=Q9BTZ2-4; Sequence=VSP_031436; Name=5; Synonyms=NRDRB2; IsoId=Q9BTZ2-5; Sequence=VSP_031436, VSP_031438; Note=Contains a phosphoserine at position 140.; Name=6; Synonyms=DHRS4L2, NRDRA1; IsoId=Q9BTZ2-6; Sequence=VSP_031435; Name=7; Synonyms=NRDRA2; IsoId=Q9BTZ2-7; Sequence=VSP_031437, VSP_031439; Note=Mainly localized in the nucleus.; Name=8; Synonyms=NRDRB1; IsoId=Q9BTZ2-8; Sequence=VSP_044947, VSP_031436; Note=Enhanced dicarbonyl reductase activity. high expression in liver.;
Catalytic Activity R-CHOH-R' + NADP(+) = R-CO-R' + NADPH.
Function Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co- factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity).
Miscellaneous Inhibited by kaempferol, quercetin, genistein and myristic acid.
Sequence Caution Sequence=AAD02292.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=AAL61824.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=BAB18775.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=BAG37057.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ;
Similarity Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Subcellular Location Isoform 7: Nucleus .
Subcellular Location Peroxisome . Note=Isoform 1 is peroxisomal, while isoform 4 is not.
Subunit Homotetramer.
Tissue Specificity Isoform 1 is predominantly expressed in normal cervix (at protein level). Isoform 4 is expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level). Isoform 5 and isoform 6 are expressed in a few neoplastic cervical tissues.

Identical and Related Proteins

Unique RefSeq proteins for LMP003412 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
32483357 RefSeq NP_066284 278 dehydrogenase/reductase SDR family member 4 isoform 1
545479056 RefSeq NP_001269916 188 dehydrogenase/reductase SDR family member 4 isoform 2
545478136 RefSeq NP_001269917 244 dehydrogenase/reductase SDR family member 4 isoform 3
545478136 RefSeq NP_001269918 244 dehydrogenase/reductase SDR family member 4 isoform 4
545478136 RefSeq NP_001269919 244 dehydrogenase/reductase SDR family member 4 isoform 5
545478136 RefSeq NP_001269920 244 dehydrogenase/reductase SDR family member 4 isoform 6

Identical Sequences to LMP003412 proteins

Reference Database Accession Length Protein Name
GI:545479056 GenBank AAT70757.1 188 NADP(H)-dependent retinol dehydrogenase A2 isoform [Homo sapiens]
GI:545478136 GenBank ABC61320.1 244 NADP(H)-dependent retinol dehydrogenase/reductase B1 isoform [Homo sapiens]
GI:545478136 GenBank ABC61320.1 244 NADP(H)-dependent retinol dehydrogenase/reductase B1 isoform [Homo sapiens]
GI:545478136 GenBank ABC61320.1 244 NADP(H)-dependent retinol dehydrogenase/reductase B1 isoform [Homo sapiens]
GI:545478136 GenBank ABC61320.1 244 NADP(H)-dependent retinol dehydrogenase/reductase B1 isoform [Homo sapiens]
GI:32483357 GenBank ABJ37883.1 278 Sequence 2 from patent US 7101984
GI:32483357 GenBank ADC20521.1 278 Sequence 1005 from patent US 7638288
GI:32483357 GenBank AFL44401.1 278 Sequence 1 from patent US 8183004
GI:32483357 GenBank AGD01482.1 278 Sequence 1005 from patent US 8338124
GI:32483357 GenBank AHD74517.1 278 Sequence 14534 from patent US 8586006
GI:32483357 SwissProt Q9BTZ2.3 278 RecName: Full=Dehydrogenase/reductase SDR family member 4; AltName: Full=NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase; Short=CR; Short=PHCR; AltName: Full=NADPH-dependent retinol dehydrogenase/reductase; Short=NRDR; Short=humNRDR; AltName: Full=Peroxisomal short-chain alcohol dehydrogenase; Short=PSCD; AltName: Full=SCAD-SRL; AltName: Full=Short-chain dehydrogenase/reductase family member 4 [Homo sapiens]

Related Sequences to LMP003412 proteins

Reference Database Accession Length Protein Name
GI:32483357 DBBJ BAA91953.1 278 unnamed protein product [Homo sapiens]
GI:32483357 EMBL CAE89847.1 278 unnamed protein product [Homo sapiens]
GI:32483357 EMBL CAH90549.1 278 hypothetical protein [Pongo abelii]
GI:545478136 GenBank AAQ89001.1 278 SCAD-SRL [Homo sapiens]
GI:545478136 GenBank AAQ89001.1 278 SCAD-SRL [Homo sapiens]
GI:545478136 GenBank AAQ89001.1 278 SCAD-SRL [Homo sapiens]
GI:545478136 GenBank AAQ89001.1 278 SCAD-SRL [Homo sapiens]
GI:545478136 RefSeq XP_001109951.1 244 PREDICTED: dehydrogenase/reductase SDR family member 4-like isoform 2 [Macaca mulatta]
GI:545478136 RefSeq XP_001109951.1 244 PREDICTED: dehydrogenase/reductase SDR family member 4-like isoform 2 [Macaca mulatta]
GI:545478136 RefSeq XP_001109951.1 244 PREDICTED: dehydrogenase/reductase SDR family member 4-like isoform 2 [Macaca mulatta]
GI:545478136 RefSeq XP_001109951.1 244 PREDICTED: dehydrogenase/reductase SDR family member 4-like isoform 2 [Macaca mulatta]
GI:545478136 RefSeq XP_001164466.1 244 PREDICTED: dehydrogenase/reductase SDR family member 4 isoform X2 [Pan troglodytes]
GI:545478136 RefSeq XP_001164466.1 244 PREDICTED: dehydrogenase/reductase SDR family member 4 isoform X2 [Pan troglodytes]
GI:545478136 RefSeq XP_001164466.1 244 PREDICTED: dehydrogenase/reductase SDR family member 4 isoform X2 [Pan troglodytes]
GI:545478136 RefSeq XP_001164466.1 244 PREDICTED: dehydrogenase/reductase SDR family member 4 isoform X2 [Pan troglodytes]
GI:32483357 RefSeq NP_001125292.1 278 dehydrogenase/reductase SDR family member 4 [Pongo abelii]
GI:545478136 RefSeq XP_003260708.1 244 PREDICTED: dehydrogenase/reductase SDR family member 4-like isoform 2 [Nomascus leucogenys]
GI:545478136 RefSeq XP_003260708.1 244 PREDICTED: dehydrogenase/reductase SDR family member 4-like isoform 2 [Nomascus leucogenys]
GI:545478136 RefSeq XP_003260708.1 244 PREDICTED: dehydrogenase/reductase SDR family member 4-like isoform 2 [Nomascus leucogenys]
GI:545478136 RefSeq XP_003260708.1 244 PREDICTED: dehydrogenase/reductase SDR family member 4-like isoform 2 [Nomascus leucogenys]
GI:545478136 RefSeq XP_004055026.1 244 PREDICTED: dehydrogenase/reductase SDR family member 4-like isoform 1 [Gorilla gorilla gorilla]
GI:545478136 RefSeq XP_004055026.1 244 PREDICTED: dehydrogenase/reductase SDR family member 4-like isoform 1 [Gorilla gorilla gorilla]
GI:545478136 RefSeq XP_004055026.1 244 PREDICTED: dehydrogenase/reductase SDR family member 4-like isoform 1 [Gorilla gorilla gorilla]
GI:545478136 RefSeq XP_004055026.1 244 PREDICTED: dehydrogenase/reductase SDR family member 4-like isoform 1 [Gorilla gorilla gorilla]
GI:545478136 RefSeq XP_005560970.1 244 PREDICTED: dehydrogenase/reductase SDR family member 4-like isoform X2 [Macaca fascicularis]
GI:545478136 RefSeq XP_005560970.1 244 PREDICTED: dehydrogenase/reductase SDR family member 4-like isoform X2 [Macaca fascicularis]
GI:545478136 RefSeq XP_005560970.1 244 PREDICTED: dehydrogenase/reductase SDR family member 4-like isoform X2 [Macaca fascicularis]
GI:545478136 RefSeq XP_005560970.1 244 PREDICTED: dehydrogenase/reductase SDR family member 4-like isoform X2 [Macaca fascicularis]
GI:545479056 RefSeq XP_005859671.1 189 PREDICTED: dehydrogenase/reductase SDR family member 4-like isoform X5 [Myotis brandtii]
GI:545479056 RefSeq XP_006102339.1 189 PREDICTED: dehydrogenase/reductase SDR family member 4-like isoform X5 [Myotis lucifugus]
GI:545479056 RefSeq XP_006760932.1 284 PREDICTED: dehydrogenase/reductase SDR family member 4-like isoform X2 [Myotis davidii]
GI:545479056 RefSeq XP_007989105.1 188 PREDICTED: dehydrogenase/reductase SDR family member 4 isoform X5 [Chlorocebus sabaeus]
GI:545479056 RefSeq XP_008156706.1 189 PREDICTED: dehydrogenase/reductase SDR family member 4 isoform X5 [Eptesicus fuscus]
GI:32483357 RefSeq XP_009247234.1 278 PREDICTED: dehydrogenase/reductase SDR family member 4 isoform X1 [Pongo abelii]
GI:545479056 RefSeq XP_009425813.1 188 PREDICTED: dehydrogenase/reductase SDR family member 4 isoform X5 [Pan troglodytes]
GI:32483357 SwissProt Q5RCF8.3 278 RecName: Full=Dehydrogenase/reductase SDR family member 4; AltName: Full=NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase; Short=CR; Short=PHCR; AltName: Full=NADPH-dependent retinol dehydrogenase/reductase; Short=NDRD; AltName: Full=Peroxisomal short-chain alcohol dehydrogenase; Short=PSCD [Pongo abelii]