Gene/Proteome Database (LMPD)

LMPD ID
LMP004002
Gene ID
26363
Species
Mus musculus (Mouse)
Gene Name
biotinidase
Gene Symbol
Btd
Synonyms
-
Alternate Names
biotinidase; biotinase
Chromosome
14
Map Location
14 B|14
EC Number
3.5.1.12

Proteins

biotinidase precursor
Refseq ID NP_079571
Protein GI 13384648
UniProt ID Q8CIF4
mRNA ID NM_025295
Length 529
RefSeq Status VALIDATED
MRSRFMVCIMSGARTAPALFFLGCSALALGVSSASQEHREAEYYVAAVYEHPSVLSPNPLELVSRQEALELMKQNLDVYEQQVMAAAQKGVQIIVFPEDGIHGFNFTRTSIYPFLDFMPSPKLVRWNPCLEPFRFNDTEVLQRLSCMAIKGGMFLVANLGTKQPCLSSDPGCPQDGRYQFNTNVVFSDNGTLVDRYRKHNLYFEAAFDTPANVDLITFDTPFAGKFGVFTCFDILFFDPAVRLLRDFEVKHIVYPTAWMNQLPLLAAIEIQKAFATAFGVNVLAANIHHPTLGMTGSGIHTPLKSFWYHDMDDPKGHLIIAQVATNPQGLTGTGNTTSEMDPSHRKFLKILSGDPYCEKDAQEVHCDEAAKWNVNVPPTFHSEMMYDNFTLVPVWGTEGHLQVCSNSLCCHLLYERPTLSKELYALGVFDGLHTVHGTYYIQTCALVKCGGLGFDTCGQEITEAEGLFDFHLWGNFSTLYIFPLFLTSGMTLDTPDQLGWENDHYFLRKRGLSSGLVTAALYGRLYERK
sig_peptide: 1..34 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 3523 peptide sequence: MRSRFMVCIMSGARTAPALFFLGCSALALGVSSA

Gene Information

Entrez Gene ID
26363
Gene Name
biotinidase
Gene Symbol
Btd
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0045177 IDA:MGI C apical part of cell
GO:0005615 IEA:Ensembl C extracellular space
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005730 IDA:MGI C nucleolus
GO:0043204 IDA:MGI C perikaryon
GO:0047708 IMP:MGI F biotinidase activity
GO:0006768 IMP:MGI P biotin metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu00780 Biotin metabolism
ko04977 Vitamin digestion and absorption
mmu04977 Vitamin digestion and absorption

REACTOME Pathway Links

REACTOME Pathway ID Description
5893521 Biotin transport and metabolism

Domain Information

InterPro Annotations

Accession Description
IPR012101 Biotinidase, eukaryotic
IPR003010 Carbon-nitrogen hydrolase

UniProt Annotations

Entry Information

Gene Name
biotinidase
Protein Entry
BTD_MOUSE
UniProt ID
Q8CIF4
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Biotin amide + H(2)O = biotin + NH(3).
Function Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation. {ECO:0000250}.
Sequence Caution Sequence=AAH24051.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB24086.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAE22509.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family. {ECO:0000305}.
Similarity Contains 1 CN hydrolase domain. {ECO:0000255|PROSITE- ProRule:PRU00054}.
Subcellular Location Secreted, extracellular space {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP004002 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13384648 RefSeq NP_079571 529 biotinidase precursor

Identical Sequences to LMP004002 proteins

Reference Database Accession Length Protein Name
GI:13384648 DBBJ BAB24086.1 529 unnamed protein product [Mus musculus]
GI:13384648 GenBank AAH24051.2 529 Biotinidase [Mus musculus]
GI:13384648 GenBank EDL24817.1 529 biotinidase, isoform CRA_b [Mus musculus]

Related Sequences to LMP004002 proteins

Reference Database Accession Length Protein Name
GI:13384648 DBBJ BAE22509.1 529 unnamed protein product [Mus musculus]
GI:13384648 RefSeq XP_003495391.1 537 PREDICTED: biotinidase isoform X1 [Cricetulus griseus]
GI:13384648 RefSeq XP_006252672.1 535 PREDICTED: biotinidase isoform X2 [Rattus norvegicus]
GI:13384648 RefSeq XP_006996306.1 525 PREDICTED: biotinidase isoform X2 [Peromyscus maniculatus bairdii]
GI:13384648 RefSeq XP_007626397.1 537 PREDICTED: biotinidase isoform X1 [Cricetulus griseus]
GI:13384648 SwissProt Q8CIF4.2 520 RecName: Full=Biotinidase; Short=Biotinase; Flags: Precursor [Mus musculus]