Gene/Proteome Database (LMPD)

LMPD ID
LMP004118
Gene ID
55625
Species
Homo sapiens (Human)
Gene Name
zinc finger, DHHC-type containing 7
Gene Symbol
ZDHHC7
Synonyms
DHHC7; SERZ-B; SERZ1; ZNF370
Alternate Names
palmitoyltransferase ZDHHC7; DHHC-7; zinc finger protein 370; zinc finger, DHHC domain containing 7; zinc finger DHHC domain-containing protein 7; Sertoli cell gene with zinc finger domain-&#946
Chromosome
16
Map Location
16q24.1
EC Number
2.3.1.225

Proteins

palmitoyltransferase ZDHHC7 isoform 1
Refseq ID NP_001139020
Protein GI 224493964
UniProt ID Q9NXF8
mRNA ID NM_001145548
Length 345
RefSeq Status VALIDATED
MQPSGHRLRDVEHHPLLAENDNYDSSSSSSSEADVADRVWFIRDGCGMICAVMTWLLVAYADFVVTFVMLLPSKDFWYSVVNGVIFNCLAVLALSSHLRTMLTDPEKSSDCRPSACTVKTGLDPTLVGICGEGTESVQSLLLGAVPKGNATKEYMESLQLKPGEVIYKCPKCCCIKPERAHHCSICKRCIRKMDHHCPWVNNCVGEKNQRFFVLFTMYIALSSVHALILCGFQFISCVRGQWTECSDFSPPITVILLIFLCLEGLLFFTFTAVMFGTQIHSICNDETEIERLKSEKPTWERRLRWEGMKSVFGGPPSLLWMNPFVGFRFRRLPTRPRKGGPEFSV
palmitoyltransferase ZDHHC7 isoform 2
Refseq ID NP_060210
Protein GI 224493956
UniProt ID Q9NXF8
mRNA ID NM_017740
Length 308
RefSeq Status VALIDATED
MQPSGHRLRDVEHHPLLAENDNYDSSSSSSSEADVADRVWFIRDGCGMICAVMTWLLVAYADFVVTFVMLLPSKDFWYSVVNGVIFNCLAVLALSSHLRTMLTDPGAVPKGNATKEYMESLQLKPGEVIYKCPKCCCIKPERAHHCSICKRCIRKMDHHCPWVNNCVGEKNQRFFVLFTMYIALSSVHALILCGFQFISCVRGQWTECSDFSPPITVILLIFLCLEGLLFFTFTAVMFGTQIHSICNDETEIERLKSEKPTWERRLRWEGMKSVFGGPPSLLWMNPFVGFRFRRLPTRPRKGGPEFSV

Gene Information

Entrez Gene ID
55625
Gene Name
zinc finger, DHHC-type containing 7
Gene Symbol
ZDHHC7
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IDA:UniProtKB C Golgi apparatus
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016409 IDA:UniProt F palmitoyltransferase activity
GO:0019706 IEA:UniProtKB-EC F protein-cysteine S-palmitoyltransferase activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0018230 IMP:UniProtKB P peptidyl-L-cysteine S-palmitoylation
GO:0018345 IDA:UniProt P protein palmitoylation

Domain Information

InterPro Annotations

Accession Description
IPR001594 Zinc finger, DHHC-type, palmitoyltransferase

UniProt Annotations

Entry Information

Gene Name
zinc finger, DHHC-type containing 7
Protein Entry
ZDHC7_HUMAN
UniProt ID
Q9NXF8
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NXF8-1; Sequence=Displayed; Name=2; IsoId=Q9NXF8-2; Sequence=VSP_006942;
Catalytic Activity Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
Domain The DHHC domain is required for palmitoyltransferase activity.
Function Palmitoyltransferase with broad specificity. Palmitoylates SNAP25 and DLG4/PSD95. May palmitoylate GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3) and thereby regulate their synaptic clustering and/or cell surface stability (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptors.
Sequence Caution Sequence=AAH17702.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=BAA91814.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ;
Similarity Belongs to the DHHC palmitoyltransferase family.
Similarity Contains 1 DHHC-type zinc finger.
Subcellular Location Membrane ; Multi-pass membrane protein . Golgi apparatus .

Identical and Related Proteins

Unique RefSeq proteins for LMP004118 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
224493964 RefSeq NP_001139020 345 palmitoyltransferase ZDHHC7 isoform 1
224493956 RefSeq NP_060210 308 palmitoyltransferase ZDHHC7 isoform 2

Identical Sequences to LMP004118 proteins

Reference Database Accession Length Protein Name
GI:224493964 GenBank AAH18772.1 345 ZDHHC7 protein [Homo sapiens]
GI:224493964 GenBank EAW95463.1 345 zinc finger, DHHC-type containing 7, isoform CRA_a [Homo sapiens]
GI:224493964 GenBank ABM82894.1 345 zinc finger, DHHC-type containing 7 [synthetic construct]
GI:224493964 GenBank ABM86083.1 345 zinc finger, DHHC-type containing 7, partial [synthetic construct]
GI:224493956 GenBank JAA40108.1 308 zinc finger, DHHC-type containing 7 [Pan troglodytes]
GI:224493964 GenBank AIC56711.1 345 ZDHHC7, partial [synthetic construct]
GI:224493956 RefSeq XP_005592742.1 308 PREDICTED: palmitoyltransferase ZDHHC7 [Macaca fascicularis]
GI:224493956 RefSeq XP_007992434.1 308 PREDICTED: palmitoyltransferase ZDHHC7 [Chlorocebus sabaeus]
GI:224493956 RefSeq XP_008972587.1 308 PREDICTED: palmitoyltransferase ZDHHC7 [Pan paniscus]
GI:224493956 RefSeq XP_008972588.1 308 PREDICTED: palmitoyltransferase ZDHHC7 [Pan paniscus]
GI:224493956 RefSeq XP_009429616.1 308 PREDICTED: palmitoyltransferase ZDHHC7 isoform X2 [Pan troglodytes]

Related Sequences to LMP004118 proteins

Reference Database Accession Length Protein Name
GI:224493956 DBBJ BAA91055.1 308 unnamed protein product [Homo sapiens]
GI:224493964 GenBank JAA07271.1 345 zinc finger, DHHC-type containing 7 [Pan troglodytes]
GI:224493964 GenBank JAA21668.1 345 zinc finger, DHHC-type containing 7 [Pan troglodytes]
GI:224493964 GenBank JAA27610.1 345 zinc finger, DHHC-type containing 7 [Pan troglodytes]
GI:224493964 GenBank JAA40109.1 345 zinc finger, DHHC-type containing 7 [Pan troglodytes]
GI:224493956 GenBank AGJ46259.1 308 Sequence 20 from patent US 8404655
GI:224493956 GenBank AHD75409.1 308 Sequence 16688 from patent US 8586006
GI:224493956 RefSeq XP_003272546.1 308 PREDICTED: palmitoyltransferase ZDHHC7 isoform 1 [Nomascus leucogenys]
GI:224493956 RefSeq XP_003922862.1 309 PREDICTED: palmitoyltransferase ZDHHC7 isoform X2 [Saimiri boliviensis boliviensis]
GI:224493964 RefSeq XP_009429614.1 345 PREDICTED: palmitoyltransferase ZDHHC7 isoform X1 [Pan troglodytes]
GI:224493964 RefSeq XP_009429615.1 345 PREDICTED: palmitoyltransferase ZDHHC7 isoform X1 [Pan troglodytes]
GI:224493956 RefSeq XP_010353924.1 308 PREDICTED: palmitoyltransferase ZDHHC7 [Rhinopithecus roxellana]