Gene/Proteome Database (LMPD)

LMPD ID
LMP004196
Gene ID
102247
Species
Mus musculus (Mouse)
Gene Name
1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta)
Gene Symbol
Agpat6
Synonyms
AU041707; AW545732; GPAT4; Tsarg7
Alternate Names
glycerol-3-phosphate acyltransferase 6; 1-AGPAT 6; LPAAT-zeta; 1-AGP acyltransferase 6; glycerol-3-phosphate acyltransferase 4; lysophosphatidic acid acyltransferase zeta; putative lysophosphatidic acid acyltransferase; acyl-CoA:glycerol-3-phosphate acyltransferase 4; testis spermatogenesis apoptosis-related protein 7
Chromosome
8
Map Location
8 A2|8
EC Number
2.3.1.15

Proteins

glycerol-3-phosphate acyltransferase 6 precursor
Refseq ID NP_061213
Protein GI 30520301
UniProt ID Q8K2C8
mRNA ID NM_018743
Length 456
RefSeq Status VALIDATED
MFLLLPFDSLIVNLLGISLTVLFTLLLVFIIVPAIFGVSFGIRKLYMKTLLKIFAWATLRMERGAKERNHQLYKPYTNGIIAKDPTSLEEEIKEIRRSGSSKALDKTPEFELSDIFYFCRKGMETIMDDEVTKRFSAEELESWNLLSRTNYNFQYISLRLTILWGLGVLIRYCFLLPLRIALAFTGIGLLVVGTTMVGYLPNGRFKEFLSKHVHLMCYRICVRALTAIITYHNRKNRPRNGGICVANHTSPIDVIILASDGYYAMVGQVHGGLMGVIQRAMVKACPHVWFERSEVKDRHLVAKRLTEHVQDKSKLPILIFPEGTCINNTSVMMFKKGSFEIGATVYPVAIKYDPQFGDAFWNSSKYGMVTYLLRMMTSWAIVCSVWYLPPMTREKDEDAVQFANRVKSAIARQGGLVDLLWDGGLKREKVKDTFKEEQQKLYSKMIVGNHEDRSRS
sig_peptide: 1..37 inference: non-experimental evidence, no additional details recorded note: Potential; propagated from UniProtKB/Swiss-Prot (Q8K2C8.1) calculated_mol_wt: 4077 peptide sequence: MFLLLPFDSLIVNLLGISLTVLFTLLLVFIIVPAIFG

Gene Information

Entrez Gene ID
102247
Gene Name
1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta)
Gene Symbol
Agpat6
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:UniProtKB C endoplasmic reticulum
GO:0030176 NAS:UniProtKB C integral component of endoplasmic reticulum membrane
GO:0004366 IMP:UniProtKB F glycerol-3-phosphate O-acyltransferase activity
GO:0016024 IEA:UniProtKB-UniPathway P CDP-diacylglycerol biosynthetic process
GO:0006637 IEA:Ensembl P acyl-CoA metabolic process
GO:0046339 IMP:MGI P diacylglycerol metabolic process
GO:0006631 IMP:MGI P fatty acid metabolic process
GO:0002071 IMP:MGI P glandular epithelial cell maturation
GO:0007595 IMP:UniProtKB P lactation
GO:0008610 IMP:UniProtKB P lipid biosynthetic process
GO:0030879 IMP:MGI P mammary gland development
GO:0006656 IEA:Ensembl P phosphatidylcholine biosynthetic process
GO:0040014 IMP:MGI P regulation of multicellular organism growth
GO:0019432 IMP:UniProtKB P triglyceride biosynthetic process
GO:0006641 IMP:MGI P triglyceride metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu00561 Glycerolipid metabolism
mmu00564 Glycerophospholipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5892982 Synthesis of PA

Domain Information

InterPro Annotations

Accession Description
IPR002123 Phospholipid/glycerol acyltransferase

UniProt Annotations

Entry Information

Gene Name
1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta)
Protein Entry
GPAT4_MOUSE
UniProt ID
Q8K2C8
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1- acyl-sn-glycerol 3-phosphate.
Domain The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. {ECO:0000250}.
Function Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long- chain fatty acyl-CoAs (By similarity). {ECO:0000250}.
Pathway Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3.
Similarity Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP004196 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
30520301 RefSeq NP_061213 456 glycerol-3-phosphate acyltransferase 6 precursor

Identical Sequences to LMP004196 proteins

Reference Database Accession Length Protein Name
GI:30520301 DBBJ BAE41020.1 456 unnamed protein product [Mus musculus]
GI:30520301 DBBJ BAE36282.1 456 unnamed protein product [Mus musculus]
GI:30520301 EMBL CAT16186.1 456 unnamed protein product [Mus musculus]
GI:30520301 GenBank AAP97283.1 456 putative lysophosphatidic acid acyltransferase [Mus musculus]
GI:30520301 GenBank EDL32868.1 456 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta), isoform CRA_b [Mus musculus]
GI:30520301 SwissProt Q8K2C8.1 456 RecName: Full=Glycerol-3-phosphate acyltransferase 4; Short=GPAT4; AltName: Full=1-acylglycerol-3-phosphate O-acyltransferase 6; Short=1-AGP acyltransferase 6; Short=1-AGPAT 6; AltName: Full=Acyl-CoA:glycerol-3-phosphate acyltransferase 4; AltName: Full=Lysophosphatidic acid acyltransferase zeta; Short=LPAAT-zeta; Flags: Precursor [Mus musculus]

Related Sequences to LMP004196 proteins

Reference Database Accession Length Protein Name
GI:30520301 GenBank EGV95030.1 456 Glycerol-3-phosphate acyltransferase 4 [Cricetulus griseus]
GI:30520301 GenBank ERE92464.1 456 glycerol-3-phosphate acyltransferase 4 [Cricetulus griseus]
GI:30520301 RefSeq XP_003503367.1 456 PREDICTED: glycerol-3-phosphate acyltransferase 6 [Cricetulus griseus]
GI:30520301 RefSeq XP_006509037.1 462 PREDICTED: glycerol-3-phosphate acyltransferase 6 isoform X1 [Mus musculus]
GI:30520301 RefSeq XP_006983035.1 456 PREDICTED: glycerol-3-phosphate acyltransferase 4 [Peromyscus maniculatus bairdii]
GI:30520301 RefSeq XP_007608062.1 456 PREDICTED: glycerol-3-phosphate acyltransferase 6 [Cricetulus griseus]