Gene/Proteome Database (LMPD)
LMPD ID
LMP004318
Gene ID
Species
Homo sapiens (Human)
Gene Name
phospholipase A2 receptor 1, 180kDa
Gene Symbol
Synonyms
CLEC13C; PLA2-R; PLA2G1R; PLA2IR; PLA2R
Chromosome
2
Map Location
2q23-q24
Summary
This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]
Orthologs
Proteins
| secretory phospholipase A2 receptor isoform 1 precursor | |
|---|---|
| Refseq ID | NP_031392 |
| Protein GI | 55953104 |
| UniProt ID | Q13018 |
| mRNA ID | NM_007366 |
| Length | 1463 |
| RefSeq Status | REVIEWED |
| MLLSPSLLLLLLLGAPRGCAEGVAAALTPERLLEWQDKGIFVIQSESLKKCIQAGKSVLTLENCKQANKHMLWKWVSNHGLFNIGGSGCLGLNFSAPEQPLSLYECDSTLVSLRWRCNRKMITGPLQYSVQVAHDNTVVASRKYIHKWISYGSGGGDICEYLHKDLHTIKGNTHGMPCMFPFQYNHQWHHECTREGREDDLLWCATTSRYERDEKWGFCPDPTSAEVGCDTIWEKDLNSHICYQFNLLSSLSWSEAHSSCQMQGGTLLSITDETEENFIREHMSSKTVEVWMGLNQLDEHAGWQWSDGTPLNYLNWSPEVNFEPFVEDHCGTFSSFMPSAWRSRDCESTLPYICKKYLNHIDHEIVEKDAWKYYATHCEPGWNPYNRNCYKLQKEEKTWHEALRSCQADNSALIDITSLAEVEFLVTLLGDENASETWIGLSSNKIPVSFEWSNDSSVIFTNWHTLEPHIFPNRSQLCVSAEQSEGHWKVKNCEERLFYICKKAGHVLSDAESGCQEGWERHGGFCYKIDTVLRSFDQASSGYYCPPALVTITNRFEQAFITSLISSVVKMKDSYFWIALQDQNDTGEYTWKPVGQKPEPVQYTHWNTHQPRYSGGCVAMRGRHPLGRWEVKHCRHFKAMSLCKQPVENQEKAEYEERWPFHPCYLDWESEPGLASCFKVFHSEKVLMKRTWREAEAFCEEFGAHLASFAHIEEENFVNELLHSKFNWTEERQFWIGFNKRNPLNAGSWEWSDRTPVVSSFLDNTYFGEDARNCAVYKANKTLLPLHCGSKREWICKIPRDVKPKIPFWYQYDVPWLFYQDAEYLFHTFASEWLNFEFVCSWLHSDLLTIHSAHEQEFIHSKIKALSKYGASWWIGLQEERANDEFRWRDGTPVIYQNWDTGRERTVNNQSQRCGFISSITGLWGSEECSVSMPSICKRKKVWLIEKKKDTPKQHGTCPKGWLYFNYKCLLLNIPKDPSSWKNWTHAQHFCAEEGGTLVAIESEVEQAFITMNLFGQTTSVWIGLQNDDYETWLNGKPVVYSNWSPFDIINIPSHNTTEVQKHIPLCALLSSNPNFHFTGKWYFEDCGKEGYGFVCEKMQDTSGHGVNTSDMYPMPNTLEYGNRTYKIINANMTWYAAIKTCLMHKAQLVSITDQYHQSFLTVVLNRLGYAHWIGLFTTDNGLNFDWSDGTKSSFTFWKDEESSLLGDCVFADSNGRWHSTACESFLQGAICHVPPETRQSEHPELCSETSIPWIKFKSNCYSFSTVLDSMSFEAAHEFCKKEGSNLLTIKDEAENAFLLEELFAFGSSVQMVWLNAQFDGNNETIKWFDGTPTDQSNWGIRKPDTDYFKPHHCVALRIPEGLWQLSPCQEKKGFICKMEADIHTAEALPEKGPSHSIIPLAVVLTLIVIVAICTLSFCIYKHNGGFFRRLAGFRNPYYPATNFSTVYLEENILISDLEKSDQ | |
| sig_peptide: 1..20 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2052 peptide sequence: MLLSPSLLLLLLLGAPRGCA sig_peptide: 1..20 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2052 peptide sequence: MLLSPSLLLLLLLGAPRGCA sig_peptide: 1..20 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2052 peptide sequence: MLLSPSLLLLLLLGAPRGCA | |
| secretory phospholipase A2 receptor isoform 2 precursor | |
|---|---|
| Refseq ID | NP_001007268 |
| Protein GI | 55953106 |
| UniProt ID | Q13018 |
| mRNA ID | NM_001007267 |
| Length | 1324 |
| RefSeq Status | REVIEWED |
| MLLSPSLLLLLLLGAPRGCAEGVAAALTPERLLEWQDKGIFVIQSESLKKCIQAGKSVLTLENCKQANKHMLWKWVSNHGLFNIGGSGCLGLNFSAPEQPLSLYECDSTLVSLRWRCNRKMITGPLQYSVQVAHDNTVVASRKYIHKWISYGSGGGDICEYLHKDLHTIKGNTHGMPCMFPFQYNHQWHHECTREGREDDLLWCATTSRYERDEKWGFCPDPTSAEVGCDTIWEKDLNSHICYQFNLLSSLSWSEAHSSCQMQGGTLLSITDETEENFIREHMSSKTVEVWMGLNQLDEHAGWQWSDGTPLNYLNWSPEVNFEPFVEDHCGTFSSFMPSAWRSRDCESTLPYICKKYLNHIDHEIVEKDAWKYYATHCEPGWNPYNRNCYKLQKEEKTWHEALRSCQADNSALIDITSLAEVEFLVTLLGDENASETWIGLSSNKIPVSFEWSNDSSVIFTNWHTLEPHIFPNRSQLCVSAEQSEGHWKVKNCEERLFYICKKAGHVLSDAESGCQEGWERHGGFCYKIDTVLRSFDQASSGYYCPPALVTITNRFEQAFITSLISSVVKMKDSYFWIALQDQNDTGEYTWKPVGQKPEPVQYTHWNTHQPRYSGGCVAMRGRHPLGRWEVKHCRHFKAMSLCKQPVENQEKAEYEERWPFHPCYLDWESEPGLASCFKVFHSEKVLMKRTWREAEAFCEEFGAHLASFAHIEEENFVNELLHSKFNWTEERQFWIGFNKRNPLNAGSWEWSDRTPVVSSFLDNTYFGEDARNCAVYKANKTLLPLHCGSKREWICKIPRDVKPKIPFWYQYDVPWLFYQDAEYLFHTFASEWLNFEFVCSWLHSDLLTIHSAHEQEFIHSKIKALSKYGASWWIGLQEERANDEFRWRDGTPVIYQNWDTGRERTVNNQSQRCGFISSITGLWGSEECSVSMPSICKRKKVWLIEKKKDTPKQHGTCPKGWLYFNYKCLLLNIPKDPSSWKNWTHAQHFCAEEGGTLVAIESEVEQAFITMNLFGQTTSVWIGLQNDDYETWLNGKPVVYSNWSPFDIINIPSHNTTEVQKHIPLCALLSSNPNFHFTGKWYFEDCGKEGYGFVCEKMQDTSGHGVNTSDMYPMPNTLEYGNRTYKIINANMTWYAAIKTCLMHKAQLVSITDQYHQSFLTVVLNRLGYAHWIGLFTTDNGLNFDWSDGTKSSFTFWKDEESSLLGDCVFADSNGRWHSTACESFLQGAICHVPPETRQSEHPELCSETSIPWIKFKSNCYSFSTVLDSMSFEAAHEFCKKEGSNLLTIKDEAENAFLLEELFAFGSSVQMVWLNAQFDGNSK | |
| secretory phospholipase A2 receptor isoform 3 precursor | |
|---|---|
| Refseq ID | NP_001182570 |
| Protein GI | 307548857 |
| UniProt ID | Q13018 |
| mRNA ID | NM_001195641 |
| Length | 1461 |
| RefSeq Status | REVIEWED |
| MLLSPSLLLLLLLGAPRGCAEGVAAALTPERLLEWQDKGIFVIQSESLKKCIQAGKSVLTLENCKQANKHMLWKWVSNHGLFNIGGSGCLGLNFSAPEQPLSLYECDSTLVSLRWRCNRKMITGPLQYSVQVAHDNTVVASRKYIHKWISYGSGGGDICEYLHKDLHTIKGNTHGMPCMFPFQYNHQWHHECTREGREDDLLWCATTSRYERDEKWGFCPDPTSAEVGCDTIWEKDLNSHICYQFNLLSSLSWSEAHSSCQMQGGTLLSITDETEENFIREHMSSKTVEVWMGLNQLDEHAGWQWSDGTPLNYLNWSPEVNFEPFVEDHCGTFSSFMPSAWRSRDCESTLPYICKKYLNHIDHEIVEKDAWKYYATHCEPGWNPYNRNCYKLQKEEKTWHEALRSCQADNSALIDITSLAEVEFLVTLLGDENASETWIGLSSNKIPVSFEWSNDSSVIFTNWHTLEPHIFPNRSQLCVSAEQSEGHWKVKNCEERLFYICKKAGHVLSDAESGCQEGWERHGGFCYKIDTVLRSFDQASSGYYCPPALVTITNRFEQAFITSLISSVVKMKDSYFWIALQDQNDTGEYTWKPVGQKPEPVQYTHWNTHQPRYSGGCVAMRGRHPLGRWEVKHCRHFKAMSLCKQPVENQEKAEYEERWPFHPCYLDWESEPGLASCFKVFHSEKVLMKRTWREAEAFCEEFGAHLASFAHIEEENFVNELLHSKFNWTEERQFWIGFNKRNPLNAGSWEWSDRTPVVSSFLDNTYFGEDARNCAVYKANKTLLPLHCGSKREWICKIPRDVKPKIPFWYQYDVPWLFYQDAEYLFHTFASEWLNFEFVCSWLHSDLLTIHSAHEQEFIHSKIKALSKYGASWWIGLQEERANDEFRWRDGTPVIYQNWDTGRERTVNNQSQRCGFISSITGLWGSEECSVSMPSICKRKKVWLIEKKKDTPKQHGTCPKGWLYFNYKCLLLNIPKDPSSWKNWTHAQHFCAEEGGTLVAIESEVEQAFITMNLFGQTTSVWIGLQNDDYETWLNGKPVVYSNWSPFDIINIPSHNTTEVQKHIPLCALLSSNPNFHFTGKWYFEDCGKEGYGFVCEKMQDTSGHGVNTSDMYPMPNTLEYGNRTYKIINANMTWYAAIKTCLMHKAQLVSITDQYHQSFLTVVLNRLGYAHWIGLFTTDNGLNFDWSDGTKSSFTFWKDEESSLLGDCVFADSNGRWHSTACESFLQGAICHVPPETRQSEHPELCSETSIPWIKFKSNCYSFSTVLDSMSFEAAHEFCKKEGSNLLTIKDEAENAFLLEELFAFGSSVQMVWLNAQFDDETIKWFDGTPTDQSNWGIRKPDTDYFKPHHCVALRIPEGLWQLSPCQEKKGFICKMEADIHTAEALPEKGPSHSIIPLAVVLTLIVIVAICTLSFCIYKHNGGFFRRLAGFRNPYYPATNFSTVYLEENILISDLEKSDQ | |
Gene Information
Entrez Gene ID
Gene Name
phospholipase A2 receptor 1, 180kDa
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0009986 | IDA:UniProtKB | C | cell surface |
| GO:0005576 | ISS:UniProtKB | C | extracellular region |
| GO:0070062 | IDA:UniProt | C | extracellular vesicular exosome |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0005887 | NAS:UniProtKB | C | integral component of plasma membrane |
| GO:0005886 | IDA:UniProtKB | C | plasma membrane |
| GO:0043235 | IDA:MGI | C | receptor complex |
| GO:0030246 | IEA:UniProtKB-KW | F | carbohydrate binding |
| GO:0043274 | IPI:UniProtKB | F | phospholipase binding |
| GO:0004872 | IDA:UniProtKB | F | receptor activity |
| GO:0001816 | IMP:UniProtKB | P | cytokine production |
| GO:1900139 | ISS:UniProtKB | P | negative regulation of arachidonic acid secretion |
| GO:1900138 | ISS:UniProtKB | P | negative regulation of phospholipase A2 activity |
| GO:0090403 | IMP:UniProtKB | P | oxidative stress-induced premature senescence |
| GO:0043517 | IMP:UniProtKB | P | positive regulation of DNA damage response, signal transduction by p53 class mediator |
| GO:0090238 | ISS:UniProtKB | P | positive regulation of arachidonic acid secretion |
| GO:0072593 | IDA:UniProtKB | P | reactive oxygen species metabolic process |
| GO:0006898 | IDA:UniProtKB | P | receptor-mediated endocytosis |
| GO:0090399 | IMP:UniProtKB | P | replicative senescence |
KEGG Pathway Links
Domain Information
UniProt Annotations
Entry Information
Gene Name
phospholipase A2 receptor 1, 180kDa
Protein Entry
PLA2R_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q13018-1; Sequence=Displayed; Name=2; IsoId=Q13018-2; Sequence=VSP_029493, VSP_029494; |
| Domain | C-type lectin domains 3-5 mediate the interaction with phospholipase PLA2G1B. |
| Domain | The endocytosis signal probably mediates endocytosis via clathrin-coated pits. |
| Function | Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2- IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2- IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow- derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B. {ECO |
| Ptm | The secretory phospholipase A2 receptor form may be produced by the action of metalloproteinases. It contains all extracellular domains and only lacks transmembrane and cytosolic regions. It is however unclear whether this form is produced by proteolytic cleavage as suggested by some experiments, or by alternative splicing, as in the case of isoform 2 that shares all characteristics of secretory phospholipase A2 receptor form (By similarity). |
| Similarity | Contains 1 fibronectin type-II domain. |
| Similarity | Contains 1 ricin B-type lectin domain. |
| Similarity | Contains 8 C-type lectin domains. |
| Subcellular Location | Cell membrane ; Single-pass type I membrane protein . |
| Subcellular Location | Isoform 2: Secreted . |
| Subcellular Location | Soluble secretory phospholipase A2 receptor: Secreted . |
| Tissue Specificity | Present in lung macrophage (at protein level). Highly expressed in kidney. Also expressed in pancreas, amnion, choriodecidua and placenta. Isoform 2 is expressed at much lower level. {ECO |
| Web Resource | Name=Functional Glycomics Gateway - Glycan Binding; Note=Phospholipase A2 receptor; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_253"; |
Identical and Related Proteins
Unique RefSeq proteins for LMP004318 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 55953104 | RefSeq | NP_031392 | 1463 | secretory phospholipase A2 receptor isoform 1 precursor |
| 55953106 | RefSeq | NP_001007268 | 1324 | secretory phospholipase A2 receptor isoform 2 precursor |
| 307548857 | RefSeq | NP_001182570 | 1461 | secretory phospholipase A2 receptor isoform 3 precursor |
Identical Sequences to LMP004318 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:55953106 | GenBank | EAX11391.1 | 1324 | phospholipase A2 receptor 1, 180kDa, isoform CRA_a [Homo sapiens] |
| GI:55953106 | GenBank | ACC03101.1 | 1324 | Sequence 40 from patent US 7332281 |
| GI:307548857 | GenBank | AAI44632.1 | 1461 | PLA2R1 protein [Homo sapiens] |
| GI:55953106 | GenBank | AEU43330.1 | 1324 | Sequence 79 from patent US 8052970 |
| GI:55953104 | GenBank | AEU43395.1 | 1463 | Sequence 144 from patent US 8052970 |
| GI:55953104 | GenBank | AEU43421.1 | 1463 | Sequence 170 from patent US 8052970 |
| GI:55953104 | GenBank | AEU43422.1 | 1463 | Sequence 171 from patent US 8052970 |
| GI:55953106 | GenBank | AEU43423.1 | 1324 | Sequence 172 from patent US 8052970 |
| GI:55953106 | GenBank | AGU31608.1 | 1324 | Sequence 1 from patent US 8507215 |
| GI:55953104 | GenBank | AGU31609.1 | 1463 | Sequence 2 from patent US 8507215 |
| GI:55953106 | GenBank | AHD73278.1 | 1324 | Sequence 10346 from patent US 8586006 |
| GI:55953104 | GenBank | AHD73279.1 | 1463 | Sequence 10347 from patent US 8586006 |
| GI:55953104 | RefSeq | XP_005246449.1 | 1463 | PREDICTED: secretory phospholipase A2 receptor isoform X1 [Homo sapiens] |
| GI:307548857 | RefSeq | XP_005246450.1 | 1461 | PREDICTED: secretory phospholipase A2 receptor isoform X2 [Homo sapiens] |
Related Sequences to LMP004318 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:55953106 | GenBank | EAX11392.1 | 1463 | phospholipase A2 receptor 1, 180kDa, isoform CRA_b [Homo sapiens] |
| GI:307548857 | GenBank | ACM82817.1 | 1478 | Sequence 8315 from patent US 6812339 |
| GI:55953104 | GenBank | ACM82817.1 | 1478 | Sequence 8315 from patent US 6812339 |
| GI:55953106 | GenBank | ACM84950.1 | 1339 | Sequence 10448 from patent US 6812339 |
| GI:55953104 | GenBank | AEU43437.1 | 1466 | Sequence 186 from patent US 8052970 |
| GI:55953106 | GenBank | AGU31609.1 | 1463 | Sequence 2 from patent US 8507215 |
| GI:55953106 | RefSeq | NP_031392.3 | 1463 | secretory phospholipase A2 receptor isoform 1 precursor [Homo sapiens] |
| GI:55953106 | RefSeq | XP_005246449.1 | 1463 | PREDICTED: secretory phospholipase A2 receptor isoform X1 [Homo sapiens] |
| GI:307548857 | RefSeq | XP_005573339.1 | 1557 | PREDICTED: secretory phospholipase A2 receptor isoform X2 [Macaca fascicularis] |
| GI:55953104 | RefSeq | XP_003820997.2 | 1561 | PREDICTED: LOW QUALITY PROTEIN: secretory phospholipase A2 receptor [Pan paniscus] |
| GI:307548857 | RefSeq | XP_003820997.2 | 1561 | PREDICTED: LOW QUALITY PROTEIN: secretory phospholipase A2 receptor [Pan paniscus] |
| GI:55953104 | RefSeq | XP_009441820.1 | 1466 | PREDICTED: secretory phospholipase A2 receptor isoform X1 [Pan troglodytes] |
| GI:55953104 | RefSeq | XP_009441821.1 | 1466 | PREDICTED: secretory phospholipase A2 receptor isoform X1 [Pan troglodytes] |
| GI:55953104 | RefSeq | XP_009441822.1 | 1466 | PREDICTED: secretory phospholipase A2 receptor isoform X1 [Pan troglodytes] |
| GI:307548857 | RefSeq | XP_009441824.1 | 1464 | PREDICTED: secretory phospholipase A2 receptor isoform X2 [Pan troglodytes] |
| GI:307548857 | RefSeq | XP_009441825.1 | 1454 | PREDICTED: secretory phospholipase A2 receptor isoform X3 [Pan troglodytes] |
| GI:307548857 | RefSeq | XP_010377414.1 | 1465 | PREDICTED: secretory phospholipase A2 receptor isoform X2 [Rhinopithecus roxellana] |
| GI:55953106 | SwissProt | Q13018.2 | 1463 | RecName: Full=Secretory phospholipase A2 receptor; Short=PLA2-R; Short=PLA2R; AltName: Full=180 kDa secretory phospholipase A2 receptor; AltName: Full=C-type lectin domain family 13 member C; AltName: Full=M-type receptor; Contains: RecName: Full=Soluble secretory phospholipase A2 receptor; Short=Soluble PLA2-R; Short=Soluble PLA2R; Flags: Precursor [Homo sapiens] |