Gene/Proteome Database (LMPD)
Proteins
| polymeric immunoglobulin receptor precursor | |
|---|---|
| Refseq ID | NP_035212 |
| Protein GI | 31981570 |
| UniProt ID | O70570 |
| mRNA ID | NM_011082 |
| Length | 771 |
| RefSeq Status | VALIDATED |
| MRLYLFTLLVTVFSGVSTKSPIFGPQEVSSIEGDSVSITCYYPDTSVNRHTRKYWCRQGASGMCTTLISSNGYLSKEYSGRANLINFPENNTFVINIEQLTQDDTGSYKCGLGTSNRGLSFDVSLEVSQVPELPSDTHVYTKDIGRNVTIECPFKRENAPSKKSLCKKTNQSCELVIDSTEKVNPSYIGRAKLFMKGTDLTVFYVNISHLTHNDAGLYICQAGEGPSADKKNVDLQVLAPEPELLYKDLRSSVTFECDLGREVANEAKYLCRMNKETCDVIINTLGKRDPDFEGRILITPKDDNGRFSVLITGLRKEDAGHYQCGAHSSGLPQEGWPIQTWQLFVNEESTIPNRRSVVKGVTGGSVAIACPYNPKESSSLKYWCRWEGDGNGHCPVLVGTQAQVQEEYEGRLALFDQPGNGTYTVILNQLTTEDAGFYWCLTNGDSRWRTTIELQVAEATREPNLEVTPQNATAVLGETFTVSCHYPCKFYSQEKYWCKWSNKGCHILPSHDEGARQSSVSCDQSSQLVSMTLNPVSKEDEGWYWCGVKQGQTYGETTAIYIAVEERTRGSSHVNPTDANARAKVALEEEVVDSSISEKENKAIPNPGPFANEREIQNVGDQAQENRASGDAGSADGQSRSSSSKVLFSTLVPLGLVLAVGAIAVWVARVRHRKNVDRMSISSYRTDISMADFKNSRDLGGNDNMGASPDTQQTVIEGKDEIVTTTECTAEPEESKKAKRSSKEEADMAYSAFLLQSSTIAAQVHDGPQEA | |
| sig_peptide: 1..18 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2047 peptide sequence: MRLYLFTLLVTVFSGVST mat_peptide: 19..771 product: Polymeric immunoglobulin receptor experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (O70570.1) calculated_mol_wt: 82970 peptide sequence: KSPIFGPQEVSSIEGDSVSITCYYPDTSVNRHTRKYWCRQGASGMCTTLISSNGYLSKEYSGRANLINFPENNTFVINIEQLTQDDTGSYKCGLGTSNRGLSFDVSLEVSQVPELPSDTHVYTKDIGRNVTIECPFKRENAPSKKSLCKKTNQSCELVIDSTEKVNPSYIGRAKLFMKGTDLTVFYVNISHLTHNDAGLYICQAGEGPSADKKNVDLQVLAPEPELLYKDLRSSVTFECDLGREVANEAKYLCRMNKETCDVIINTLGKRDPDFEGRILITPKDDNGRFSVLITGLRKEDAGHYQCGAHSSGLPQEGWPIQTWQLFVNEESTIPNRRSVVKGVTGGSVAIACPYNPKESSSLKYWCRWEGDGNGHCPVLVGTQAQVQEEYEGRLALFDQPGNGTYTVILNQLTTEDAGFYWCLTNGDSRWRTTIELQVAEATREPNLEVTPQNATAVLGETFTVSCHYPCKFYSQEKYWCKWSNKGCHILPSHDEGARQSSVSCDQSSQLVSMTLNPVSKEDEGWYWCGVKQGQTYGETTAIYIAVEERTRGSSHVNPTDANARAKVALEEEVVDSSISEKENKAIPNPGPFANEREIQNVGDQAQENRASGDAGSADGQSRSSSSKVLFSTLVPLGLVLAVGAIAVWVARVRHRKNVDRMSISSYRTDISMADFKNSRDLGGNDNMGASPDTQQTVIEGKDEIVTTTECTAEPEESKKAKRSSKEEADMAYSAFLLQSSTIAAQVHDGPQEA mat_peptide: 19..611 product: Secretory component experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (O70570.1) calculated_mol_wt: 65810 peptide sequence: KSPIFGPQEVSSIEGDSVSITCYYPDTSVNRHTRKYWCRQGASGMCTTLISSNGYLSKEYSGRANLINFPENNTFVINIEQLTQDDTGSYKCGLGTSNRGLSFDVSLEVSQVPELPSDTHVYTKDIGRNVTIECPFKRENAPSKKSLCKKTNQSCELVIDSTEKVNPSYIGRAKLFMKGTDLTVFYVNISHLTHNDAGLYICQAGEGPSADKKNVDLQVLAPEPELLYKDLRSSVTFECDLGREVANEAKYLCRMNKETCDVIINTLGKRDPDFEGRILITPKDDNGRFSVLITGLRKEDAGHYQCGAHSSGLPQEGWPIQTWQLFVNEESTIPNRRSVVKGVTGGSVAIACPYNPKESSSLKYWCRWEGDGNGHCPVLVGTQAQVQEEYEGRLALFDQPGNGTYTVILNQLTTEDAGFYWCLTNGDSRWRTTIELQVAEATREPNLEVTPQNATAVLGETFTVSCHYPCKFYSQEKYWCKWSNKGCHILPSHDEGARQSSVSCDQSSQLVSMTLNPVSKEDEGWYWCGVKQGQTYGETTAIYIAVEERTRGSSHVNPTDANARAKVALEEEVVDSSISEKENKAIPNPGPFA | |
Gene Information
Entrez Gene ID
Gene Name
polymeric immunoglobulin receptor
Gene Symbol
Species
Mus musculus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005615 | IEA:Ensembl | C | extracellular space |
| GO:0070062 | IEA:Ensembl | C | extracellular vesicular exosome |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0005886 | IEA:UniProtKB-KW | C | plasma membrane |
| GO:0043235 | ISO:MGI | C | receptor complex |
| GO:0001792 | IEA:Ensembl | F | polymeric immunoglobulin receptor activity |
| GO:0001580 | IEA:Ensembl | P | detection of chemical stimulus involved in sensory perception of bitter taste |
| GO:0007173 | IEA:Ensembl | P | epidermal growth factor receptor signaling pathway |
| GO:0002415 | IEA:Ensembl | P | immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor |
| GO:0043113 | IEA:Ensembl | P | receptor clustering |
| GO:0001895 | IEA:Ensembl | P | retina homeostasis |
KEGG Pathway Links
Domain Information
UniProt Annotations
Entry Information
Gene Name
polymeric immunoglobulin receptor
Protein Entry
PIGR_MOUSE
UniProt ID
Species
Mouse
Comments
| Comment Type | Description |
|---|---|
| Function | This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment (By similarity). {ECO:0000250}. |
| Similarity | Contains 5 Ig-like V-type (immunoglobulin-like) domains. {ECO:0000305}. |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. |
| Subcellular Location | Secretory component: Secreted. |
Identical and Related Proteins
Unique RefSeq proteins for LMP004831 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 31981570 | RefSeq | NP_035212 | 771 | polymeric immunoglobulin receptor precursor |
Identical Sequences to LMP004831 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:31981570 | DBBJ | BAE25149.1 | 771 | unnamed protein product [Mus musculus] |
| GI:31981570 | GenBank | AAH13556.1 | 771 | Polymeric immunoglobulin receptor [Mus musculus] |
| GI:31981570 | GenBank | AAY01386.1 | 771 | Sequence 4 from patent US 6855810 |
| GI:31981570 | GenBank | EDL39729.1 | 771 | polymeric immunoglobulin receptor [Mus musculus] |
| GI:31981570 | GenBank | ACH17901.1 | 771 | Sequence 4 from patent US 7404954 |
| GI:31981570 | SwissProt | O70570.1 | 771 | RecName: Full=Polymeric immunoglobulin receptor; Short=PIgR; Short=Poly-Ig receptor; Contains: RecName: Full=Secretory component; Flags: Precursor [Mus musculus] |
Related Sequences to LMP004831 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:31981570 | GenBank | AAA67440.1 | 771 | polymeric immunoglobulin receptor [Mus musculus] |
| GI:31981570 | GenBank | AAE83442.1 | 771 | Sequence 8 from patent US 6303341 |
| GI:31981570 | GenBank | AAW11607.1 | 771 | Sequence 8 from patent US 6808709 |
| GI:31981570 | GenBank | ABT01732.1 | 771 | Sequence 8 from patent US 7211389 |
| GI:31981570 | GenBank | ACH17900.1 | 769 | Sequence 3 from patent US 7404954 |
| GI:31981570 | SwissProt | P15083.1 | 769 | RecName: Full=Polymeric immunoglobulin receptor; Short=PIgR; Short=Poly-Ig receptor; Contains: RecName: Full=Secretory component; Flags: Precursor [Rattus norvegicus] |