Gene/Proteome Database (LMPD)

LMPD ID
LMP004872
Gene ID
17330
Species
Mus musculus (Mouse)
Gene Name
multiple inositol polyphosphate histidine phosphatase 1
Gene Symbol
Minpp1
Synonyms
AA408516
Alternate Names
multiple inositol polyphosphate phosphatase 1; 2,3-BPG phosphatase; ins(1,3,4,5)P(4) 3-phosphatase; 2,3-bisphosphoglycerate 3-phosphatase; inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase
Chromosome
19
Map Location
19 C1|19 27.25 cM
EC Number
3.1.3.62

Proteins

multiple inositol polyphosphate phosphatase 1 precursor
Refseq ID NP_034929
Protein GI 6754698
UniProt ID Q9Z2L6
mRNA ID NM_010799
Length 481
RefSeq Status VALIDATED
MLRGARSHLPASVAPAAVLAAALLSSFARCSLPGRGDPVASVLSPYFGTKTRYEDANPWLLVDPVAPRRDPELLAGTCTPVQLVALIRHGTRYPTTKQIRKLKQLQGLLQTRESRDGGSQVAAALAEWPLWYGDWMDGQLVEKGRQDMRQLALRLAALFPDLFSRENYDRLRLITSSKHRCVDSSAAFLQGLWQHYHPGLPPPDVSDMECGPPRINDKLMRFFDHCEKFLTDVERNETALYHVEAFKTGPEMQKVLKKVAATLQVPMNSLNADLIQVAFFTCSFDLAIKGVHSPWCDVFDVDDARVLEYLNDLKQYWKRSYGYTINSRSSCNLFQDIFLHLDKAVEQKQRSQPVSSPVILQFGHAETLLPLLSLMGYFKDKEPLTAYNFEEQVNRKFRSGHIVPYASNLIFVLYHCDNAQSPEEQFQIQLLLNEKVLPLAHSQRPVGLYEELKTHYRDILQSCQTSKECSPPKANITSDEL
sig_peptide: 1..30 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 3009 peptide sequence: MLRGARSHLPASVAPAAVLAAALLSSFARC mat_peptide: 31..481 product: Multiple inositol polyphosphate phosphatase 1 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9Z2L6.3) calculated_mol_wt: 51547 peptide sequence: SLPGRGDPVASVLSPYFGTKTRYEDANPWLLVDPVAPRRDPELLAGTCTPVQLVALIRHGTRYPTTKQIRKLKQLQGLLQTRESRDGGSQVAAALAEWPLWYGDWMDGQLVEKGRQDMRQLALRLAALFPDLFSRENYDRLRLITSSKHRCVDSSAAFLQGLWQHYHPGLPPPDVSDMECGPPRINDKLMRFFDHCEKFLTDVERNETALYHVEAFKTGPEMQKVLKKVAATLQVPMNSLNADLIQVAFFTCSFDLAIKGVHSPWCDVFDVDDARVLEYLNDLKQYWKRSYGYTINSRSSCNLFQDIFLHLDKAVEQKQRSQPVSSPVILQFGHAETLLPLLSLMGYFKDKEPLTAYNFEEQVNRKFRSGHIVPYASNLIFVLYHCDNAQSPEEQFQIQLLLNEKVLPLAHSQRPVGLYEELKTHYRDILQSCQTSKECSPPKANITSDEL

Gene Information

Entrez Gene ID
17330
Gene Name
multiple inositol polyphosphate histidine phosphatase 1
Gene Symbol
Minpp1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0003993 IEA:InterPro F acid phosphatase activity
GO:0034417 IEA:UniProtKB-EC F bisphosphoglycerate 3-phosphatase activity
GO:0052826 IEA:UniProtKB-EC F inositol hexakisphosphate 2-phosphatase activity

KEGG Pathway Links

KEGG Pathway ID Description
mmu00562 Inositol phosphate metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6364 D-myo-inositol (1,3,4)-trisphosphate biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5894026 Inositol phosphate metabolism
5894030 Synthesis of IPs in the ER lumen

Domain Information

InterPro Annotations

Accession Description
IPR016274 Histidine acid phosphatase, eukaryotic
IPR029033 Histidine phosphatase superfamily
IPR000560 Histidine phosphatase superfamily, clade-2

UniProt Annotations

Entry Information

Gene Name
multiple inositol polyphosphate histidine phosphatase 1
Protein Entry
MINP1_MOUSE
UniProt ID
Q9Z2L6
Species
Mouse

Comments

Comment Type Description
Catalytic Activity 2,3-bisphospho-D-glycerate + H(2)O = 2- phospho-D-glycerate + phosphate. {ECO:0000269|PubMed:10087200}.
Catalytic Activity Myo-inositol hexakisphosphate + H(2)O = myo- inositol pentakisphosphate (mixed isomers) + phosphate. {ECO:0000269|PubMed:10087200}.
Developmental Stage Expressed in different stages of embryogenesis, from E7.5 through E14.5. The highest levels of expression is found in the visceral endoderm at E7.5 and E8.5 and in the fetal liver at E12.5 and E14.5. {ECO:0000269|PubMed:10938126}.
Function Acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3- BPG) to produce phospho-D-glycerate without formation of 3- phosphoglycerate (By similarity). Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). May play a role in bone development (endochondral ossification). {ECO:0000250, ECO:0000269|PubMed:10938126}.
Sequence Caution Sequence=BAA95058.1; Type=Frameshift; Positions=14, 176; Evidence={ECO:0000305};
Similarity Belongs to the histidine acid phosphatase family. MINPP1 subfamily. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}. Cell membrane {ECO:0000305|PubMed:10938126}. Note=Also attached to the plasma membrane in erythrocytes. {ECO:0000305}.
Tissue Specificity Widely expressed with highest levels in kidney, intestine, thymus and liver.

Identical and Related Proteins

Unique RefSeq proteins for LMP004872 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6754698 RefSeq NP_034929 481 multiple inositol polyphosphate phosphatase 1 precursor

Identical Sequences to LMP004872 proteins

Reference Database Accession Length Protein Name
GI:6754698 DBBJ BAE30439.1 481 unnamed protein product [Mus musculus]
GI:6754698 GenBank AAD02434.1 481 multiple inositol polyphosphate phosphatase [Mus musculus]
GI:6754698 SwissProt Q9Z2L6.3 481 RecName: Full=Multiple inositol polyphosphate phosphatase 1; AltName: Full=2,3-bisphosphoglycerate 3-phosphatase; Short=2,3-BPG phosphatase; AltName: Full=Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase; Short=Ins(1,3,4,5)P(4) 3-phosphatase; Flags: Precursor [Mus musculus]

Related Sequences to LMP004872 proteins

Reference Database Accession Length Protein Name
GI:6754698 GenBank AAH21437.1 481 Minpp1 protein [Mus musculus]
GI:6754698 GenBank AAC53453.2 481 hepatic multiple inositol polyphosphate phosphatase [Rattus norvegicus]
GI:6754698 GenBank EDL41725.1 506 multiple inositol polyphosphate histidine phosphatase 1, isoform CRA_b [Mus musculus]
GI:6754698 GenBank EDM13138.1 481 rCG47320 [Rattus norvegicus]
GI:6754698 RefSeq NP_062136.1 481 multiple inositol polyphosphate phosphatase 1 precursor [Rattus norvegicus]
GI:6754698 SwissProt O35217.3 481 RecName: Full=Multiple inositol polyphosphate phosphatase 1; AltName: Full=2,3-bisphosphoglycerate 3-phosphatase; Short=2,3-BPG phosphatase; AltName: Full=Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase; Short=Ins(1,3,4,5)P(4) 3-phosphatase; Flags: Precursor [Rattus norvegicus]