Gene/Proteome Database (LMPD)

LMPD ID
LMP004978
Gene ID
54965
Species
Homo sapiens (Human)
Gene Name
phosphatidylinositol glycan anchor biosynthesis, class X
Gene Symbol
PIGX
Synonyms
PIG-X
Alternate Names
phosphatidylinositol-glycan biosynthesis class X protein; GPI-mannosyltransferase subunit
Chromosome
3
Map Location
3q29
Summary
This gene encodes a type I transmembrane protein in the endoplasmic reticulum (ER). The protein is an essential component of glycosylphosphatidylinositol-mannosyltransferase I, which transfers the first of the four mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Studies in rat indicate that the protein is translated from a non-AUG translation initiation site. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Orthologs
View orthologs and multiple alignments for PIGX

Proteins

phosphatidylinositol-glycan biosynthesis class X protein isoform 1 precursor
Refseq ID NP_001159776
Protein GI 261490708
UniProt ID Q8TBF5
mRNA ID NM_001166304
Length 276
RefSeq Status REVIEWED
MAARVAAVRAAAWLLLGAATGLTRGPAAAFTAARSDAGIRAMCSEIILRQEVLKDGFHRDLLIKVKFGESIEDLHTCRLLIKQDIPAGLYVDPYELASLRERNITEAVMVSENFDIEAPNYLSKESEVLIYARRDSQCIDCFQAFLPVHCRYHRPHSEDGEASIVVNNPDLLMFCDQAGSRRMIRFRFDSFDKTIEFPILKCWAHSEVAAPCALENEDICQWNKMKYKSVYKNVILQVPVGLTVHTSLVCSVTLLITILCSTLILVAVFKYGHFSL
phosphatidylinositol-glycan biosynthesis class X protein isoform 2 precursor
Refseq ID NP_060331
Protein GI 261490706
UniProt ID Q8TBF5
mRNA ID NM_017861
Length 258
RefSeq Status REVIEWED
MAARVAAVRAAAWLLLGAATGLTRGPAAAFTAARSDAGIRAMCSEIILRQEVLKDGFHRDLLIKVKFGESIEDLHTCRLLIKQDIPAGLYVDPYELASLRERNITEAVMVSENFDIEAPNYLSKESEVLIYARRDSQCIDCFQAFLPVHCRYHRPHSEDGEASIVVNNPDLLMFCDQEFPILKCWAHSEVAAPCALENEDICQWNKMKYKSVYKNVILQVPVGLTVHTSLVCSVTLLITILCSTLILVAVFKYGHFSL
sig_peptide: 1..21 note: SignalP 3.0 Server prediction calculated_mol_wt: 2040 peptide sequence: MAARVAAVRAAAWLLLGAATG mat_peptide: 22..276 product: phosphatidylinositol-glycan biosynthesis class X protein isoform 1 calculated_mol_wt: 28952 peptide sequence: LTRGPAAAFTAARSDAGIRAMCSEIILRQEVLKDGFHRDLLIKVKFGESIEDLHTCRLLIKQDIPAGLYVDPYELASLRERNITEAVMVSENFDIEAPNYLSKESEVLIYARRDSQCIDCFQAFLPVHCRYHRPHSEDGEASIVVNNPDLLMFCDQAGSRRMIRFRFDSFDKTIEFPILKCWAHSEVAAPCALENEDICQWNKMKYKSVYKNVILQVPVGLTVHTSLVCSVTLLITILCSTLILVAVFKYGHFSL sig_peptide: 1..21 note: SignalP 3.0 Server prediction calculated_mol_wt: 2040 peptide sequence: MAARVAAVRAAAWLLLGAATG mat_peptide: 22..258 product: phosphatidylinositol-glycan biosynthesis class X protein isoform 2 calculated_mol_wt: 26766 peptide sequence: LTRGPAAAFTAARSDAGIRAMCSEIILRQEVLKDGFHRDLLIKVKFGESIEDLHTCRLLIKQDIPAGLYVDPYELASLRERNITEAVMVSENFDIEAPNYLSKESEVLIYARRDSQCIDCFQAFLPVHCRYHRPHSEDGEASIVVNNPDLLMFCDQEFPILKCWAHSEVAAPCALENEDICQWNKMKYKSVYKNVILQVPVGLTVHTSLVCSVTLLITILCSTLILVAVFKYGHFSL

Gene Information

Entrez Gene ID
54965
Gene Name
phosphatidylinositol glycan anchor biosynthesis, class X
Gene Symbol
PIGX
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0006501 TAS:Reactome P C-terminal protein lipidation
GO:0044267 TAS:Reactome P cellular protein metabolic process
GO:0043687 TAS:Reactome P post-translational protein modification
GO:0016254 TAS:Reactome P preassembly of GPI anchor in ER membrane

KEGG Pathway Links

KEGG Pathway ID Description
hsa00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
ko00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
hsa01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_952 Synthesis of glycosylphosphatidylinositol (GPI)

Domain Information

InterPro Annotations

Accession Description
IPR013233 Glycosylphosphatidylinositol-mannosyltransferase I, PIG-X/PBN1

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol glycan anchor biosynthesis, class X
Protein Entry
PIGX_HUMAN
UniProt ID
Q8TBF5
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8TBF5-1; Sequence=Displayed; Name=2; IsoId=Q8TBF5-2; Sequence=VSP_019842; Note=No experimental confirmation available.;
Function Essential component of glycosylphosphatidylinositol- mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase PIGM (By similarity).
Pathway Glycolipid biosynthesis; glycosylphosphatidylinositol- anchor biosynthesis.
Ptm N-glycosylated.
Sequence Caution Sequence=AAH22542.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=AAH22542.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence= ; Sequence=BAA91233.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=BAA91233.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence= ; Sequence=BAA91233.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence= ;
Similarity Belongs to the PIGX family.
Subcellular Location Endoplasmic reticulum membrane {ECO
Subunit Interacts with PIGM.

Identical and Related Proteins

Unique RefSeq proteins for LMP004978 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
261490708 RefSeq NP_001159776 276 phosphatidylinositol-glycan biosynthesis class X protein isoform 1 precursor
261490706 RefSeq NP_060331 258 phosphatidylinositol-glycan biosynthesis class X protein isoform 2 precursor

Identical Sequences to LMP004978 proteins

Reference Database Accession Length Protein Name
GI:261490706 SwissProt Q8TBF5.3 258 RecName: Full=Phosphatidylinositol-glycan biosynthesis class X protein; Short=PIG-X; Flags: Precursor [Homo sapiens]

Related Sequences to LMP004978 proteins

Reference Database Accession Length Protein Name
GI:261490708 GenBank EHH51797.1 239 hypothetical protein EGM_11242, partial [Macaca fascicularis]
GI:261490706 RefSeq XP_003926466.1 430 PREDICTED: phosphatidylinositol-glycan biosynthesis class X protein [Saimiri boliviensis boliviensis]
GI:261490706 RefSeq XP_004038315.1 412 PREDICTED: phosphatidylinositol-glycan biosynthesis class X protein [Gorilla gorilla gorilla]
GI:261490708 RefSeq XP_004038315.1 412 PREDICTED: phosphatidylinositol-glycan biosynthesis class X protein [Gorilla gorilla gorilla]
GI:261490706 RefSeq XP_003280177.2 432 PREDICTED: phosphatidylinositol-glycan biosynthesis class X protein [Nomascus leucogenys]
GI:261490708 RefSeq XP_003280177.2 432 PREDICTED: phosphatidylinositol-glycan biosynthesis class X protein [Nomascus leucogenys]
GI:261490708 RefSeq XP_004278883.1 354 PREDICTED: phosphatidylinositol-glycan biosynthesis class X protein [Orcinus orca]
GI:261490706 RefSeq XP_006742937.1 335 PREDICTED: phosphatidylinositol-glycan biosynthesis class X protein [Leptonychotes weddellii]
GI:261490708 RefSeq XP_007465948.1 395 PREDICTED: phosphatidylinositol-glycan biosynthesis class X protein [Lipotes vexillifer]
GI:261490706 RefSeq XP_008979716.1 369 PREDICTED: phosphatidylinositol-glycan biosynthesis class X protein [Callithrix jacchus]
GI:261490708 RefSeq XP_009237968.1 371 PREDICTED: phosphatidylinositol-glycan biosynthesis class X protein [Pongo abelii]
GI:261490706 RefSeq XP_009237968.1 371 PREDICTED: phosphatidylinositol-glycan biosynthesis class X protein [Pongo abelii]