Gene/Proteome Database (LMPD)

LMPD ID
LMP005023
Gene ID
51196
Species
Homo sapiens (Human)
Gene Name
phospholipase C, epsilon 1
Gene Symbol
PLCE1
Synonyms
NPHS3; PLCE; PPLC
Chromosome
10
Map Location
10q23
EC Number
3.1.4.11
Summary
This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]
Orthologs
View orthologs and multiple alignments for PLCE1

Proteins

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform 1
Refseq ID NP_057425
Protein GI 117168250
UniProt ID Q9P212
mRNA ID NM_016341
Length 2302
RefSeq Status REVIEWED
MTSEEMTASVLIPVTQRKVVSAQSAADESSEKVSDINISKAHTVRRSGETSHTISQLNKLKEEPSGSNLPKILSIAREKIVSDENSNEKCWEKIMPDSAKNLNINCNNILRNHQHGLPQRQFYEMYNSVAEEDLCLETGIPSPLERKVFPGIQLELDRPSMGISPLGNQSVIIETGRAHPDSRRAVFHFHYEVDRRMSDTFCTLSENLILDDCGNCVPLPGGEEKQKKNYVAYTCKLMELAKNCDNKNEQLQCDHCDTLNDKYFCFEGSCEKVDMVYSGDSFCRKDFTDSQAAKTFLSHFEDFPDNCDDVEEDAFKSKKERSTLLVRRFCKNDREVKKSVYTGTRAIVRTLPSGHIGLTAWSYIDQKRNGPLLPCGRVMEPPSTVEIRQDGSQRLSEAQWYPIYNAVRREETENTVGSLLHFLTKLPASETAHGRISVGPCLKQCVRDTVCEYRATLQRTSISQYITGSLLEATTSLGARSGLLSTFGGSTGRMMLKERQPGPSVANSNALPSSSAGISKELIDLQPLIQFPEEVASILMEQEQTIYRRVLPVDYLCFLTRDLGTPECQSSLPCLKASISASILTTQNGEHNALEDLVMRFNEVSSWVTWLILTAGSMEEKREVFSYLVHVAKCCWNMGNYNAVMEFLAGLRSRKVLKMWQFMDQSDIETMRSLKDAMAQHESSCEYRKVVTRALHIPGCKVVPFCGVFLKELCEVLDGASGLMKLCPRYNSQEETLEFVADYSGQDNFLQRVGQNGLKNSEKESTVNSIFQVIRSCNRSLETDEEDSPSEGNSSRKSSLKDKSRWQFIIGDLLDSDNDIFEQSKEYDSHGSEDSQKAFDHGTELIPWYVLSIQADVHQFLLQGATVIHYDQDTHLSARCFLQLQPDNSTLTWVKPTTASPASSKAKLGVLNNTAEPGKFPLLGNAGLSSLTEGVLDLFAVKAVYMGHPGIDIHTVCVQNKLGSMFLSETGVTLLYGLQTTDNRLLHFVAPKHTAKMLFSGLLELTRAVRKMRKFPDQRQQWLRKQYVSLYQEDGRYEGPTLAHAVELFGGRRWSARNPSPGTSAKNAEKPNMQRNNTLGISTTKKKKKILMRGESGEVTDDEMATRKAKMHKECRSRSGSDPQDINEQEESEVNAIANPPNPLPSRRAHSLTTAGSPNLAAGTSSPIRPVSSPVLSSSNKSPSSAWSSSSWHGRIKGGMKGFQSFMVSDSNMSFVEFVELFKSFSVRSRKDLKDLFDVYAVPCNRSGSESAPLYTNLTIDENTSDLQPDLDLLTRNVSDLGLFIKSKQQLSDNQRQISDAIAAASIVTNGTGIESTSLGIFGVGILQLNDFLVNCQGEHCTYDEILSIIQKFEPSISMCHQGLMSFEGFARFLMDKENFASKNDESQENIKELQLPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSVELDCWDGDDGMPIIYHGHTLTTKIPFKEVVEAIDRSAFINSDLPIIISIENHCSLPQQRKMAEIFKTVFGEKLVTKFLFETDFSDDPMLPSPDQLRKKVLLKNKKLKAHQTPVDILKQKAHQLASMQVQAYNGGNANPRPANNEEEEDEEDEYDYDYESLSDDNILEDRPENKSCNDKLQFEYNEEIPKRIKKADNSACNKGKVYDMELGEEFYLDQNKKESRQIAPELSDLVIYCQAVKFPGLSTLNASGSSRGKERKSRKSIFGNNPGRMSPGETASFNKTSGKSSCEGIRQTWEESSSPLNPTTSLSAIIRTPKCYHISSLNENAAKRLCRRYSQKLTQHTACQLLRTYPAATRIDSSNPNPLMFWLHGIQLVALNYQTDDLPLHLNAAMFEANGGCGYVLKPPVLWDKNCPMYQKFSPLERDLDSMDPAVYSLTIVSGQNVCPSNSMGSPCIEVDVLGMPLDSCHFRTKPIHRNTLNPMWNEQFLFHVHFEDLVFLRFAVVENNSSAVTAQRIIPLKALKRGYRHLQLRNLHNEVLEISSLFINSRRMEENSSGNTMSASSMFNTEERKCLQTHRVTVHGVPGPEPFTVFTINGGTKAKQLLQQILTNEQDIKPVTTDYFLMEEKYFISKEKNECRKQPFQRAIGPEEEIMQILSSWFPEEGYMGRIVLKTQQENLEEKNIVQDDKEVILSSEEESFFVQVHDVSPEQPRTVIKAPRVSTAQDVIQQTLCKAKYSYSILSNPNPSDYVLLEEVVKDTTNKKTTTPKSSQRVLLDQECVFQAQSKWKGAGKFILKLKEQVQASREDKKKGISFASELKKLTKSTKQPRGLTSPSQLLTSESIQTKEEKPVGGLSSSDTMDYRQ
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform 2
Refseq ID NP_001159451
Protein GI 260166694
UniProt ID Q9P212
mRNA ID NM_001165979
Length 1994
RefSeq Status REVIEWED
MVSEGSAAGRDFAGMEEVRQLHVRFCKGIKIWHQAWFLCSLLGREPQEREAGCQLWLCTLSAVLKVGWLFPLSEVPNFTLLKDGCGCWRLKEDQIYNAVRREETENTVGSLLHFLTKLPASETAHGRISVGPCLKQCVRDTVCEYRATLQRTSISQYITGSLLEATTSLGARSGLLSTFGGSTGRMMLKERQPGPSVANSNALPSSSAGISKELIDLQPLIQFPEEVASILMEQEQTIYRRVLPVDYLCFLTRDLGTPECQSSLPCLKASISASILTTQNGEHNALEDLVMRFNEVSSWVTWLILTAGSMEEKREVFSYLVHVAKCCWNMGNYNAVMEFLAGLRSRKVLKMWQFMDQSDIETMRSLKDAMAQHESSCEYRKVVTRALHIPGCKVVPFCGVFLKELCEVLDGASGLMKLCPRYNSQEETLEFVADYSGQDNFLQRVGQNGLKNSEKESTVNSIFQVIRSCNRSLETDEEDSPSEGNSSRKSSLKDKSRWQFIIGDLLDSDNDIFEQSKEYDSHGSEDSQKAFDHGTELIPWYVLSIQADVHQFLLQGATVIHYDQDTHLSARCFLQLQPDNSTLTWVKPTTASPASSKAKLGVLNNTAEPGKFPLLGNAGLSSLTEGVLDLFAVKAVYMGHPGIDIHTVCVQNKLGSMFLSETGVTLLYGLQTTDNRLLHFVAPKHTAKMLFSGLLELTRAVRKMRKFPDQRQQWLRKQYVSLYQEDGRYEGPTLAHAVELFGGRRWSARNPSPGTSAKNAEKPNMQRNNTLGISTTKKKKKILMRGESGEVTDDEMATRKAKMHKECRSRSGSDPQDINEQEESEVNAIANPPNPLPSRRAHSLTTAGSPNLAAGTSSPIRPVSSPVLSSSNKSPSSAWSSSSWHGRIKGGMKGFQSFMVSDSNMSFVEFVELFKSFSVRSRKDLKDLFDVYAVPCNRSGSESAPLYTNLTIDENTSDLQPDLDLLTRNVSDLGLFIKSKQQLSDNQRQISDAIAAASIVTNGTGIESTSLGIFGVGILQLNDFLVNCQGEHCTYDEILSIIQKFEPSISMCHQGLMSFEGFARFLMDKENFASKNDESQENIKELQLPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSVELDCWDGDDGMPIIYHGHTLTTKIPFKEVVEAIDRSAFINSDLPIIISIENHCSLPQQRKMAEIFKTVFGEKLVTKFLFETDFSDDPMLPSPDQLRKKVLLKNKKLKAHQTPVDILKQKAHQLASMQVQAYNGGNANPRPANNEEEEDEEDEYDYDYESLSDDNILEDRPENKSCNDKLQFEYNEEIPKRIKKADNSACNKGKVYDMELGEEFYLDQNKKESRQIAPELSDLVIYCQAVKFPGLSTLNASGSSRGKERKSRKSIFGNNPGRMSPGETASFNKTSGKSSCEGIRQTWEESSSPLNPTTSLSAIIRTPKCYHISSLNENAAKRLCRRYSQKLTQHTACQLLRTYPAATRIDSSNPNPLMFWLHGIQLVALNYQTDDLPLHLNAAMFEANGGCGYVLKPPVLWDKNCPMYQKFSPLERDLDSMDPAVYSLTIVSGQNVCPSNSMGSPCIEVDVLGMPLDSCHFRTKPIHRNTLNPMWNEQFLFHVHFEDLVFLRFAVVENNSSAVTAQRIIPLKALKRGYRHLQLRNLHNEVLEISSLFINSRRMEENSSGNTMSASSMFNTEERKCLQTHRVTVHGVPGPEPFTVFTINGGTKAKQLLQQILTNEQDIKPVTTDYFLMEEKYFISKEKNECRKQPFQRAIGPEEEIMQILSSWFPEEGYMGRIVLKTQQENLEEKNIVQDDKEVILSSEEESFFVQVHDVSPEQPRTVIKAPRVSTAQDVIQQTLCKAKYSYSILSNPNPSDYVLLEEVVKDTTNKKTTTPKSSQRVLLDQECVFQAQSKWKGAGKFILKLKEQVQASREDKKKGISFASELKKLTKSTKQPRGLTSPSQLLTSESIQTKEEKPVGGLSSSDTMDYRQ
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform 3
Refseq ID NP_001275918
Protein GI 572882727
UniProt ID Q9P212
mRNA ID NM_001288989
Length 2286
RefSeq Status REVIEWED
MTSEEMTASVLIPVTQRKVVSAQSAADESSEKVSDINISKAHTVRRSGETSHTISQLNKLKEEPSGSNLPKILSIAREKIVSDENSNEKCWEKIMPDSAKNLNINCNNILRNHQHGLPQRQFYEMYNSVAEEDLCLETGIPSPLERKVFPGIQLELDRPSMGISPLGNQSVIIETGRAHPDSRRAVFHFHYEVDRRMSDTFCTLSENLILDDCGNCVPLPGGEEKQKKNYVAYTCKLMELAKNCDNKNEQLQCDHCDTLNDKYFCFEGSCEKVDMVYSGDSFCRKDFTDSQAAKTFLSHFEDFPDNCDDVEEDAFKSKKERSTLLVRRFCKNDREVKKSVYTGTRAIVRTLPSGHIGLTAWSYIDQKRNGPLLPCGRVMEPPSTVEIRQDGSQRLSEAQWYPIYNAVRREETENTVGSLLHFLTKLPASETAHGRISVGPCLKQCVRDTVCEYRATLQRTSISQYITGSLLEATTSLGARSGLLSTFGGSTGRMMLKERQPGPSVANSNALPSSSAGISKELIDLQPLIQFPEEVASILMEQEQTIYRRVLPVDYLCFLTRDLGTPECQSSLPCLKASISASILTTQNGEHNALEDLVMRFNEVSSWVTWLILTAGSMEEKREVFSYLVHVAKCCWNMGNYNAVMEFLAGLRSRKVLKMWQFMDQSDIETMRSLKDAMAQHESSCEYRKVVTRALHIPGCKVVPFCGVFLKELCEVLDGASGLMKLCPRYNSQEETLEFVADYSGQDNFLQRVGQNGLKNSEKESTVNSIFQVIRSCNRSLETDEEDSPSEGNSSRKSSLKDKSRWQFIIGDLLDSDNDIFEQSKEYDSHGSEDSQKAFDHGTELIPWYVLSIQADVHQFLLQGATVIHYDQDTHLSARCFLQLQPDNSTLTWVKPTTASPASSKAKLGVLNNTAEPGKFPLLGNAGLSSLTEGVLDLFAVKAVYMGHPGIDIHTVCVQNKLGSMFLSETGVTLLYGLQTTDNRLLHFVAPKHTAKMLFSGLLELTRAVRKMRKFPDQRQQWLRKQYVSLYQEDGRYEGPTLAHAVELFGGRRWSARNPSPGTSAKNAEKPNMQRNNTLGISTTKKKKKILMRGESGEVTDDEMATRKAKMHKECRSRSGSDPQDINEQEESEVNAIANPPNPLPSRRAHSLTTAGSPNLAAGTSSPISAWSSSSWHGRIKGGMKGFQSFMVSDSNMSFVEFVELFKSFSVRSRKDLKDLFDVYAVPCNRSGSESAPLYTNLTIDENTSDLQPDLDLLTRNVSDLGLFIKSKQQLSDNQRQISDAIAAASIVTNGTGIESTSLGIFGVGILQLNDFLVNCQGEHCTYDEILSIIQKFEPSISMCHQGLMSFEGFARFLMDKENFASKNDESQENIKELQLPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSVELDCWDGDDGMPIIYHGHTLTTKIPFKEVVEAIDRSAFINSDLPIIISIENHCSLPQQRKMAEIFKTVFGEKLVTKFLFETDFSDDPMLPSPDQLRKKVLLKNKKLKAHQTPVDILKQKAHQLASMQVQAYNGGNANPRPANNEEEEDEEDEYDYDYESLSDDNILEDRPENKSCNDKLQFEYNEEIPKRIKKADNSACNKGKVYDMELGEEFYLDQNKKESRQIAPELSDLVIYCQAVKFPGLSTLNASGSSRGKERKSRKSIFGNNPGRMSPGETASFNKTSGKSSCEGIRQTWEESSSPLNPTTSLSAIIRTPKCYHISSLNENAAKRLCRRYSQKLTQHTACQLLRTYPAATRIDSSNPNPLMFWLHGIQLVALNYQTDDLPLHLNAAMFEANGGCGYVLKPPVLWDKNCPMYQKFSPLERDLDSMDPAVYSLTIVSGQNVCPSNSMGSPCIEVDVLGMPLDSCHFRTKPIHRNTLNPMWNEQFLFHVHFEDLVFLRFAVVENNSSAVTAQRIIPLKALKRGYRHLQLRNLHNEVLEISSLFINSRRMEENSSGNTMSASSMFNTEERKCLQTHRVTVHGVPGPEPFTVFTINGGTKAKQLLQQILTNEQDIKPVTTDYFLMEEKYFISKEKNECRKQPFQRAIGPEEEIMQILSSWFPEEGYMGRIVLKTQQENLEEKNIVQDDKEVILSSEEESFFVQVHDVSPEQPRTVIKAPRVSTAQDVIQQTLCKAKYSYSILSNPNPSDYVLLEEVVKDTTNKKTTTPKSSQRVLLDQECVFQAQSKWKGAGKFILKLKEQVQASREDKKKGISFASELKKLTKSTKQPRGLTSPSQLLTSESIQTKEEKPVGGLSSSDTMDYRQ

Gene Information

Entrez Gene ID
51196
Gene Name
phospholipase C, epsilon 1
Gene Symbol
PLCE1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0005737 IDA:HPA C cytoplasm
GO:0005829 IDA:UniProtKB C cytosol
GO:0005886 IDA:UniProtKB C plasma membrane
GO:0017016 TAS:UniProtKB F Ras GTPase binding
GO:0005509 IEA:InterPro F calcium ion binding
GO:0019899 IPI:UniProtKB F enzyme binding
GO:0005085 TAS:UniProtKB F guanyl-nucleotide exchange factor activity
GO:0004435 IDA:UniProtKB F phosphatidylinositol phospholipase C activity
GO:0004629 IDA:UniProtKB F phospholipase C activity
GO:0005057 TAS:UniProtKB F receptor signaling protein activity
GO:0007265 TAS:UniProtKB P Ras protein signal transduction
GO:0000187 IDA:UniProtKB P activation of MAPK activity
GO:0019722 NAS:UniProtKB P calcium-mediated signaling
GO:0008283 NAS:UniProtKB P cell proliferation
GO:0007010 NAS:UniProtKB P cytoskeleton organization
GO:0006651 TAS:UniProtKB P diacylglycerol biosynthetic process
GO:0007173 NAS:UniProtKB P epidermal growth factor receptor signaling pathway
GO:0032835 IMP:HGNC P glomerulus development
GO:0007507 TAS:UniProtKB P heart development
GO:0043647 TAS:Reactome P inositol phosphate metabolic process
GO:0048016 TAS:UniProtKB P inositol phosphate-mediated signaling
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0007200 IDA:UniProtKB P phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0006644 IC:UniProtKB P phospholipid metabolic process
GO:0043547 TAS:GOC P positive regulation of GTPase activity
GO:0007204 TAS:UniProtKB P positive regulation of cytosolic calcium ion concentration
GO:0007205 NAS:UniProtKB P protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0008277 IDA:UniProtKB P regulation of G-protein coupled receptor protein signaling pathway
GO:0046578 IDA:UniProtKB P regulation of Ras protein signal transduction
GO:0001558 TAS:UniProtKB P regulation of cell growth
GO:0045859 IDA:UniProtKB P regulation of protein kinase activity
GO:0006940 TAS:UniProtKB P regulation of smooth muscle contraction
GO:0044281 TAS:Reactome P small molecule metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa04015 Rap1 signaling pathway
hsa04014 Ras signaling pathway
hsa04919 Thyroid hormone signaling pathway
hsa04024 cAMP signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR028398 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
IPR000008 C2 domain
IPR011992 EF-hand domain pair
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR001192 Phosphoinositide phospholipase C family
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR023578 Ras guanine nucleotide exchange factor domain
IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
IPR000159 Ras-association
IPR029071 Ubiquitin-related domain

UniProt Annotations

Entry Information

Gene Name
phospholipase C, epsilon 1
Protein Entry
PLCE1_HUMAN
UniProt ID
Q9P212
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=PLCepsilon1a; IsoId=Q9P212-1; Sequence=Displayed; Name=2; Synonyms=PLCepsilon1b; IsoId=Q9P212-2; Sequence=VSP_021335, VSP_021336; Note=Ref.2 (AAG28341) sequence is in conflict in position: 69:L->P. ;
Catalytic Activity 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. {ECO
Cofactor Name=Ca(2+); Xref=ChEBI
Disease Nephrotic syndrome 3 (NPHS3) [MIM
Domain The Ras-GEF domain has a GEF activity towards HRAS and RAP1A. Mediates activation of the mitogen-activated protein kinase pathway.
Domain The Ras-associating domain 1 is degenerated and may not bind HRAS. The Ras-associating domain 2 mediates interaction with GTP-bound HRAS, RAP1A, RAP2A and RAP2B and recruitment of HRAS to the cell membrane.
Enzyme Regulation Activated by the heterotrimeric G-protein subunits GNA12, GNA13 and GNB1-GNG2. Activated by HRAS, RAP1A, RHOA, RHOB, RHOC, RRAS and RRAS2. Activated by the G(s)-coupled GPCRs ADRB2, PTGER1 and CHRM3 through cyclic-AMP formation and RAP2B activation. Inhibited by G(i)-coupled GPCRs. {ECO
Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine- exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. {ECO
Induction Overexpressed during heart failure.
Sequence Caution Sequence=AAF22005.1; Type=Frameshift; Positions=1131; Evidence= ; Sequence=AAG17145.2; Type=Frameshift; Positions=2296; Evidence= ; Sequence=BAA96040.2; Type=Erroneous initiation; Evidence= ; Sequence=BAB14090.1; Type=Erroneous initiation; Evidence= ; Sequence=CAH70739.1; Type=Erroneous gene model prediction; Evidence= ; Sequence=CAH73288.1; Type=Erroneous gene model prediction; Evidence= ; Sequence=CAH73757.1; Type=Erroneous gene model prediction; Evidence= ; Sequence=CAI16674.1; Type=Erroneous gene model prediction; Evidence= ;
Similarity Contains 1 C2 domain. {ECO
Similarity Contains 1 PI-PLC X-box domain. {ECO
Similarity Contains 1 PI-PLC Y-box domain. {ECO
Similarity Contains 1 Ras-GEF domain. {ECO
Similarity Contains 2 Ras-associating domains.
Subcellular Location Cytoplasm, cytosol. Cell membrane. Golgi apparatus membrane. Note=Recruited to plasma membrane by activated HRAS and RAP2. Recruited to perinuclear membrane by activated RAP1A. Isoform 1 and isoform 2 associates with Golgi membranes.
Subunit Interacts with RHOA (By similarity). Interacts with IQGAP1, HRAS, RAP1A, RAP2A, RAP2B and RRAS. {ECO
Tissue Specificity Widely expressed. Isoform 1 is broadly expressed and only absent in peripheral blood leukocytes. Isoform 2 is specifically expressed in placenta, lung and spleen. {ECO

Identical and Related Proteins

Unique RefSeq proteins for LMP005023 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
117168250 RefSeq NP_057425 2302 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform 1
260166694 RefSeq NP_001159451 1994 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform 2
572882727 RefSeq NP_001275918 2286 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform 3

Identical Sequences to LMP005023 proteins

Reference Database Accession Length Protein Name
GI:260166694 GenBank EAW50042.1 1994 phospholipase C, epsilon 1, isoform CRA_a [Homo sapiens]
GI:117168250 GenBank EAW50043.1 2302 phospholipase C, epsilon 1, isoform CRA_b [Homo sapiens]
GI:572882727 GenBank AAI44287.1 2286 PLCE1 protein [Homo sapiens]
GI:117168250 GenBank AAI40706.1 2302 Phospholipase C, epsilon 1 [Homo sapiens]
GI:117168250 SwissProt Q9P212.3 2302 RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1; AltName: Full=Pancreas-enriched phospholipase C; AltName: Full=Phosphoinositide phospholipase C-epsilon-1; AltName: Full=Phospholipase C-epsilon-1; Short=PLC-epsilon-1 [Homo sapiens]

Related Sequences to LMP005023 proteins

Reference Database Accession Length Protein Name
GI:572882727 DBBJ BAA96040.2 2304 KIAA1516 protein, partial [Homo sapiens]
GI:117168250 DBBJ BAA96040.2 2304 KIAA1516 protein, partial [Homo sapiens]
GI:117168250 DBBJ BAG10469.1 2302 phospholipase C, epsilon 1, partial [synthetic construct]
GI:260166694 GenBank AAG28341.1 1994 phospholipase C epsilon, partial [Homo sapiens]
GI:572882727 GenBank EAW50043.1 2302 phospholipase C, epsilon 1, isoform CRA_b [Homo sapiens]
GI:117168250 GenBank AAI51855.1 2302 Phospholipase C, epsilon 1 [Homo sapiens]
GI:572882727 GenBank AAI40706.1 2302 Phospholipase C, epsilon 1 [Homo sapiens]
GI:572882727 RefSeq NP_057425.3 2302 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform 1 [Homo sapiens]
GI:260166694 RefSeq XP_003255288.1 1995 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform 1 [Nomascus leucogenys]
GI:260166694 RefSeq XP_003825424.1 1994 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3 [Pan paniscus]
GI:260166694 RefSeq XP_003904070.1 1995 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X8 [Papio anubis]
GI:260166694 RefSeq XP_005566048.1 1995 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X6 [Macaca fascicularis]
GI:117168250 RefSeq XP_006717949.1 2316 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X2 [Homo sapiens]
GI:117168250 RefSeq XP_006717950.1 2316 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3 [Homo sapiens]
GI:117168250 RefSeq XP_006717951.1 2315 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X4 [Homo sapiens]
GI:572882727 RefSeq XP_006717952.1 2300 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5 [Homo sapiens]
GI:260166694 RefSeq XP_006717953.1 2008 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X6 [Homo sapiens]
GI:572882727 SwissProt Q9P212.3 2302 RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1; AltName: Full=Pancreas-enriched phospholipase C; AltName: Full=Phosphoinositide phospholipase C-epsilon-1; AltName: Full=Phospholipase C-epsilon-1; Short=PLC-epsilon-1 [Homo sapiens]