Gene/Proteome Database (LMPD)

LMPD ID
LMP005046
Gene ID
256435
Species
Homo sapiens (Human)
Gene Name
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
Gene Symbol
ST6GALNAC3
Synonyms
PRO7177; SIAT7C; ST6GALNACIII; STY
Alternate Names
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; SIAT7-C; ST6GALNAC III; sialyltransferase 7C; GalNAc alpha-2,6-sialyltransferase III; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase III; ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltran; sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) C
Chromosome
1
Map Location
1p31.1
EC Number
2.4.99.-
Summary
ST6GALNAC3 belongs to a family of sialyltransferases that transfer sialic acids from CMP-sialic acid to terminal positions of carbohydrate groups in glycoproteins and glycolipids (Lee et al., 1999 [PubMed 10207017]).[supplied by OMIM, Mar 2008]
Orthologs
View orthologs and multiple alignments for ST6GALNAC3

Proteins

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform 1
Refseq ID NP_694541
Protein GI 229892273
UniProt ID Q8NDV1
mRNA ID NM_152996
Length 305
RefSeq Status VALIDATED
MACILKRKSVIAVSFIAAFLFLLVVRLVNEVNFPLLLNCFGQPGTKWIPFSYTYRRPLRTHYGYINVKTQEPLQLDCDLCAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGRMTMIRVVSHTSVPLLLKNPDYFFKEANTTIYVIWGPFRNMRKDGNGIVYNMLKKTVGIYPNAQIYVTTEKRMSYCDGVFKKETGKDRVQSGSYLSTGWFTFLLAMDACYGIHVYGMINDTYCKTEGYRKVPYHYYEQGRDECDEYFLHEHAPYGGHRFITEKKVFAKWAKKHRIIFTHPNWTLS
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform 2
Refseq ID NP_001153483
Protein GI 229892275
UniProt ID Q8NDV1
mRNA ID NM_001160011
Length 210
RefSeq Status VALIDATED
MACILKRKSVIAVSFIAAFLFLLVVRLVNEVNFPLLLNCFGQPGTKWIPFSYTYRRPLRTHYGYINVKTQEPLQLDCDLCAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGRMTMIRVVSHTSVPLLLKNPDYFFKEANTTIYVIWGPFRNMRKDGNGIVYNMLKKTVGIYPNAQIYVTTEKRMSYCDGVFKKETGKDSTE

Gene Information

Entrez Gene ID
256435
Gene Name
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
Gene Symbol
ST6GALNAC3
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0008373 IDA:BHF-UCL F sialyltransferase activity
GO:0009100 IDA:BHF-UCL P glycoprotein metabolic process
GO:0006687 IDA:BHF-UCL P glycosphingolipid metabolic process
GO:0006677 IDA:BHF-UCL P glycosylceramide metabolic process
GO:0006486 IEA:UniProtKB-UniPathway P protein glycosylation
GO:0097503 IDA:GOC P sialylation

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_200727 O-linked glycosylation
REACT_115606 O-linked glycosylation of mucins
REACT_200874 Sialic acid metabolism
REACT_115835 Termination of O-glycan biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR001675 Glycosyl transferase, family 29

UniProt Annotations

Entry Information

Gene Name
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
Protein Entry
SIA7C_HUMAN
UniProt ID
Q8NDV1
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8NDV1-1; Sequence=Displayed; Name=2; IsoId=Q8NDV1-2; Sequence=VSP_013218, VSP_013219;
Catalytic Activity CMP-N-acetylneuraminate + alpha-N- acetylneuraminyl-2,3-beta-D-galactosyl-1,3-(N-acetyl-D- galactosaminyl)-glycoprotein = CMP + alpha-N-acetylneuraminyl-2,3- beta-D-galactosyl-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D- galactosaminyl)-glycoprotein.
Function Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. ST6GalNAcIII prefers glycolipids to glycoproteins (By similarity).
Pathway Protein modification; protein glycosylation.
Similarity Belongs to the glycosyltransferase 29 family.
Subcellular Location Golgi apparatus membrane ; Single-pass type II membrane protein .
Web Resource Name=Functional Glycomics Gateway - GTase; Note=ST6GalNAc III; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_632";
Web Resource Name=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST6GALNAC3";

Identical and Related Proteins

Unique RefSeq proteins for LMP005046 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
229892273 RefSeq NP_694541 305 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform 1
229892275 RefSeq NP_001153483 210 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform 2

Identical Sequences to LMP005046 proteins

Reference Database Accession Length Protein Name
GI:229892273 EMBL CAD45371.1 305 alpha 2,6-sialyltransferase [Homo sapiens]
GI:229892275 GenBank ADI54150.1 210 Sequence 536 from patent US 7423120
GI:229892275 GenBank ADL73347.1 210 Sequence 536 from patent US 7696319
GI:229892275 GenBank ADL91517.1 210 Sequence 536 from patent US 7709602
GI:229892275 GenBank ADL91827.1 210 Sequence 536 from patent US 7709603
GI:229892275 GenBank ADL97908.1 210 Sequence 536 from patent US 7718770
GI:229892275 GenBank AEU55355.1 210 Sequence 536 from patent US 8063186
GI:229892273 SwissProt Q8NDV1.1 305 RecName: Full=Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; AltName: Full=GalNAc alpha-2,6-sialyltransferase III; AltName: Full=ST6GalNAc III; Short=ST6GalNAcIII; AltName: Full=STY; AltName: Full=Sialyltransferase 7C; Short=SIAT7-C [Homo sapiens]

Related Sequences to LMP005046 proteins

Reference Database Accession Length Protein Name
GI:229892273 DBBJ BAC03611.1 305 unnamed protein product [Homo sapiens]
GI:229892275 EMBL CAD45371.1 305 alpha 2,6-sialyltransferase [Homo sapiens]
GI:229892273 EMBL CAS91684.1 305 unnamed protein product [Homo sapiens]
GI:229892273 GenBank ABA66708.1 305 Sequence 2350 from patent US 6943241
GI:229892273 GenBank ACH32638.1 305 Sequence 7118 from patent US 7411051
GI:229892275 GenBank ACH32638.1 305 Sequence 7118 from patent US 7411051
GI:229892273 GenBank ACH35518.1 305 Sequence 10008 from patent US 7411051
GI:229892273 GenBank AHD77390.1 305 Sequence 22523 from patent US 8586006
GI:229892275 RefSeq NP_694541.2 305 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform 1 [Homo sapiens]
GI:229892275 RefSeq XP_008958181.1 246 PREDICTED: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X2 [Pan paniscus]
GI:229892275 RefSeq XP_010345734.1 210 PREDICTED: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X2 [Saimiri boliviensis boliviensis]
GI:229892275 SwissProt Q8NDV1.1 305 RecName: Full=Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; AltName: Full=GalNAc alpha-2,6-sialyltransferase III; AltName: Full=ST6GalNAc III; Short=ST6GalNAcIII; AltName: Full=STY; AltName: Full=Sialyltransferase 7C; Short=SIAT7-C [Homo sapiens]